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Rising Price of Opioid OD Antidote Could Cost Lives: Study

Posted 3 hours 33 minutes ago by Drugs.com

WEDNESDAY, Dec. 7, 2016 – Escalating prices of the drug naloxone may threaten efforts to reduce opioid-related deaths across America, a team from Yale University and the Mayo Clinic warns. Naloxone is a drug given to people who overdose on prescription opioids and heroin. If administered in time, it can reverse the toxic and potentially deadly effects of "opioid intoxication." The research team called attention to skyrocketing prices for the lifesaving antidote, noting: Hospira (a Pfizer Inc. company) charges $142 for a 10-pack of naloxone – up 129 percent since 2012. Amphastar's 1 milligram version of naloxone is used off-label as a nasal spray. It's priced around $40 – a 95 percent increase since September 2014. Newer, easier-to-use formulations are even more expensive – a two-dose package of Evzio (naloxone) costs $4,500, an increase of more than 500 percent over two years. ... Read more

Related support groups: Suboxone, Opiate Dependence, Opiate Withdrawal, Hepatitis C, Drug Dependence, Epinephrine, Talwin Nx, EpiPen, Adrenalin, Primatene Mist, Zubsolv, Opiate Adjunct, Septocaine, Naloxone, Toxic Reactions Incl Drug and Substance Abuse, Bunavail, Buprenorphine/Naloxone, EpiPen 2-Pak, Naloxone/Pentazocine, Articaine/Epinephrine

Most on Opioid Painkillers OK With Getting Overdose Antidote: Survey

Posted 13 Sep 2016 by Drugs.com

TUESDAY, Sept. 13, 2016 – A new, small survey of people taking powerful opioid painkillers like OxyContin and Vicodin found that most were willing to also fill prescriptions for an overdose antidote. Three patients even used the antidote to treat an apparent overdose within a few months, the researchers said. The findings provide more evidence to support wider access to the antidote naloxone, better known by the brand name Narcan. "Physicians should absolutely consider prescribing naloxone with opioids," said study co-author Dr. Phillip Coffin. He is director of substance use research with the San Francisco Department of Public Health's Center for Public Health Research. "Some providers have voiced concern that prescribing naloxone to patients could result in negative patient reactions," Coffin added. "We found that this was rare. Even among the few with a negative initial reaction, ... Read more

Related support groups: Suboxone, Oxycodone, Hydrocodone, Percocet, OxyContin, Vicodin, Norco, Opiate Dependence, Lortab, Opiate Withdrawal, Roxicodone, Drug Dependence, Endocet, Acetaminophen/Hydrocodone, Percocet 10/325, Vicoprofen, Hydromet, Roxicet, Acetaminophen/Oxycodone, Talwin Nx

Giving OD Antidote to Those Using Powerful Painkillers Might Save Lives

Posted 28 Jun 2016 by Drugs.com

MONDAY, June 27, 2016 – In the wake of the musician Prince's death from a painkiller overdose, a new study suggests some opioid-related deaths could be prevented by routinely prescribing an antidote for certain patients who take the medications. Researchers found that those who received prescriptions for the antidote naloxone (Evzio) were less likely to return for emergency care related to their painkiller use. "The study should encourage primary-care providers to prescribe naloxone to their patients on chronic opioid therapy," said Dr. Alexander Walley. He's an addiction specialist and assistant professor of medicine at Boston University School of Medicine. He was not involved in the study. According to a federal report released earlier this month, an estimated 2 million people in the United States were addicted to prescription opioid painkillers like OxyContin and Vicodin in ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, Tramadol, OxyContin, Vicodin, Norco, Fentanyl, Opiate Dependence, Morphine, Codeine, Lortab, Opiate Withdrawal, Opana, Subutex, Dilaudid, Opana ER

Shortages of Lifesaving Drugs Linger in U.S.

Posted 6 May 2016 by Drugs.com

FRIDAY, May 6, 2016 – Drug shortages remain a problem in the United States despite government legislation meant to boost availability, a new study finds. More than half of recent shortages involved acute-care drugs used to treat seriously ill patients in hospitals and emergency departments, according to researchers at Yale University, in New Haven, Conn. Those drugs include antibiotics, intravenous saline and naloxone, which is used to treat drug overdoses. "Our key finding was that up to 2012, shortages were rising for both non-acute and acute drugs," said study senior author Dr. Arjun Venkatesh, an assistant professor of emergency medicine. Since 2012, when the U.S. Food and Drug Administration was authorized to deal with the crisis, "the shortages for non-acute drugs are decreasing and getting shorter but the shortages for acute drugs are increasing and getting longer," Venkatesh ... Read more

Related support groups: Suboxone, Talwin Nx, Narcan, Zubsolv, Naloxone, Bunavail, Buprenorphine/Naloxone, Naloxone/Pentazocine, Targiniq ER, Evzio, Narcan Injection, Naloxone/oxycodone

FDA Approves Nasal Spray to Reverse Narcotic Painkiller Overdose

Posted 20 Nov 2015 by Drugs.com

THURSDAY, Nov. 19, 2015 – A nasal spray that treats narcotic painkiller and heroin drug overdoses has been approved by the U.S. Food and Drug Administration. The newly approved nasal spray (Narcan) contains the medication naloxone hydrochloride, which can stop or reverse the effects of a narcotic (also called opioid) drug overdose. Narcan is the first approved nasal spray version of the medication and offers an important new easy-to-use treatment option for family members and first responders dealing with a heroin or narcotic painkiller overdose, the FDA said. Narcotic painkillers include prescription pain drugs such as oxycodone (OxyContin), hydrocodone (when combined with acetaminophen, it's called Vicodin or Percocet) and morphine. Narcan can also reverse the effects of heroin. Drug overdose deaths are currently the leading cause of injury death in the United States, the FDA said. ... Read more

Related support groups: Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, Tramadol, OxyContin, Vicodin, Norco, Fentanyl, Morphine, Codeine, Lortab, Opana, Subutex, Dilaudid, Heroin, Opana ER, Roxicodone, MS Contin

FDA Approves Narcan (naloxone) Nasal Spray to Treat Opioid Overdose

Posted 18 Nov 2015 by Drugs.com

November 18, 2015 – Today the U.S. Food and Drug Administration approved Narcan nasal spray, the first FDA-approved nasal spray version of naloxone hydrochloride, a life-saving medication that can stop or reverse the effects of an opioid overdose. Opioids are a class of drugs that include prescription medications such as oxycodone, hydrocodone, and morphine, as well as the illegal drug heroin. Drug overdose deaths, driven largely by prescription drug overdoses, are now the leading cause of injury death in the United States – surpassing motor vehicle crashes. In 2013, the Centers for Disease Control and Prevention reported the number of drug overdose deaths had steadily increased for more than a decade. When someone overdoses on an opioid, it can be difficult to awaken the person, and breathing may become shallow or stop – leading to death if there is no medical intervention. If nal ... Read more

Related support groups: Oxycodone, Hydrocodone, Morphine, Narcotic, Overdose, Hydromorphone, Oxymorphone, Narcan, Naloxone, Opioid Overdose

Wider Use of Naloxone Could Cut Deaths From Drug Overdoses: CDC

Posted 24 Apr 2015 by Drugs.com

FRIDAY, April 24, 2015 – Allowing more emergency medical service (EMS) workers to administer the prescription drug naloxone could reduce the number of overdose deaths caused by opioid drugs, U.S. health officials said Friday. Opioids include powerful prescription narcotic painkillers such as Vicodin, OxyContin, Percocet and codeine as well as heroin. Prescription opioids caused more than 16,000 deaths in the United States in 2013, while heroin caused more than 8,000 deaths, the officials said. Naloxone is a prescription drug that can be lifesaving if given in time to people who have overdosed on prescription opioids or heroin. U.S. Centers for Disease Control and Prevention researchers reviewed nationwide data from 2012 and found that advanced EMS staffers were more likely than basic EMS staffers to administer naloxone. One of the big reasons: as of 2014, only 12 states allowed basic ... Read more

Related support groups: Suboxone, Talwin Nx, Narcan, Zubsolv, Toxic Reactions Incl Drug and Substance Abuse, Naloxone, Opioid Overdose, Bunavail, Buprenorphine/Naloxone, Naloxone/Pentazocine, Naloxone/oxycodone, Evzio

Most Who Abuse Painkillers Are Unprepared If Overdose Strikes: Study

Posted 2 Oct 2014 by Drugs.com

THURSDAY, Oct. 2, 2014 – Although teens and young adults who abuse prescription painkillers face a high risk of overdose, most don't know how to respond when one occurs, new research shows. At issue is the increasingly popular, non-medicinal use of legal prescription narcotic pain medications, including so-called "opioids" such as Oxycontin and Vicodin. Such drugs can substantially slow or even halt the ability to breath, sometimes leading to death. And while safe and effective interventions are available (including the prescription medication naloxone), the new study found that most narcotic abusers are unaware of their options. "What we found is that when it comes to how to handle an overdose, prescription opioid users who weren't using drugs for official medical reasons were less savvy than, say, more traditional heroin-using populations," said study author David Frank, a doctoral ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, Tramadol, OxyContin, Vicodin, Norco, Fentanyl, Morphine, Codeine, Lortab, Opana, Subutex, Dilaudid, Heroin, Opana ER, Roxicodone

Targiniq ER Tough-to-Abuse Formulation of Oxycodone Approved

Posted 25 Jul 2014 by Drugs.com

THURSDAY, July 24, 2014 – Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has been approved by the U.S. Food and Drug Administration as a long-term, around-the-clock treatment for severe pain when other therapies are ineffective or unavailable. The long-acting form of oxycodone, an opioid painkiller, has properties that are designed to deter abuse of the drug by snorting or injection, the FDA said in a news release. Targiniq contains naloxone, designed to block the euphoric effects of oxycodone, the agency said. Targiniq can still be abused by taking too many pills, the FDA warned, stressing that an overdose could cause death. The drug is not meant for as-needed pain relief, the agency said, repeating its warning of the potential for abuse and addiction. Targiniq ER was evaluated in a clinical study of 601 people with chronic lower back pain. The most ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Percocet, OxyContin, Roxicodone, Endocet, Percocet 10/325, Roxicet, Acetaminophen/Oxycodone, Talwin Nx, Percocet 5/325, Narcan, Zubsolv, OxyIR, Percocet 7.5/325, Naloxone, Percodan, Oxyfast, Bunavail

FDA Approves Targiniq ER Extended-Release Oxycodone with Abuse-Deterrent Properties

Posted 23 Jul 2014 by Drugs.com

July 23, 2014 – Today, the U.S. Food and Drug Administration approved Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended-release tablets), an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Targiniq ER is the second ER/LA opioid analgesic with FDA-approved labeling describing the product’s abuse-deterrent properties consistentwith the FDA’s 2013 draft guidance for industry, Abuse-Deterrent Opioids – Evaluation and Labeling. Targiniq ER has properties that are expected to deter, but not totally prevent, abuse of the drug by snorting and injection. When crushed and snorted, or crushed, dissolved and injected, the naloxone in Targiniq ER blocks the euphoric effects of oxycodone, making it less liked by abusers th ... Read more

Related support groups: Pain, Oxycodone, Chronic Pain, Severe Pain, Naloxone

FDA Approves Quick-Acting Drug to Reverse Prescription Painkiller ODs

Posted 3 Apr 2014 by Drugs.com

THURSDAY, April 3, 2014 – The first prescription treatment that can be used by family members or caregivers to treat an overdose of narcotic painkillers has been approved by the U.S. Food and Drug Administration. Evzio is a hand-held auto injector that delivers a single dose of the drug naloxone into the muscle or beneath the skin. The injector can be carried in a pocket or stored in a medicine cabinet and is meant as an emergency treatment for people who have suffered a known or suspected overdose of powerful pain drugs called opioids. Opioids include prescription narcotic painkillers such as Oxycontin, Vicodin and Percocet – all of which have shown increasing rates of abuse in recent years. "Tragically, the most recent data shows that more than 16,000 lives are lost each year due to opioid-related overdoses," FDA Commissioner Margaret Hamburg said in an agency statement. "In fact, ... Read more

Related support groups: Oxycodone, OxyContin, Morphine, Heroin, Naloxone, Opioid Overdose

FDA Approves Evzio (naloxone) Hand-Held Auto-Injector to Reverse Opioid Overdose

Posted 3 Apr 2014 by Drugs.com

April 3, 2014 – The U.S. Food and Drug Administration today approved a prescription treatment that can be used by family members or caregivers to treat a person known or suspected to have had an opioid overdose. Evzio (naloxone hydrochloride injection) rapidly delivers a single dose of the drug naloxone via a hand-held auto-injector that can be carried in a pocket or stored in a medicine cabinet. It is intended for the emergency treatment of known or suspected opioid overdose, characterized by decreased breathing or heart rates, or loss of consciousness. Drug overdose deaths, driven largely by prescription drug overdose deaths, are now the leading cause of injury death in the United States – surpassing motor vehicle crashes. In 2013, the Centers for Disease Control and Prevention reported the number of drug overdose deaths had steadily increased for more than a decade. Naloxone is a ... Read more

Related support groups: Oxycodone, OxyContin, Morphine, Narcotic, Heroin, Naloxone

U.S. Officials Target Escalating Drug Overdoses

Posted 11 Feb 2014 by Drugs.com

TUESDAY, Feb. 11 – As deaths from heroin and prescription painkillers mount across the United States, government officials are searching for ways to stem the toll of addiction. The death last week of Oscar-winning actor Philip Seymour Hoffman, 46, in New York City from an apparent heroin overdose highlighted this escalating problem. "The use of opioids – a group of drugs that includes heroin and prescription painkillers – is having a devastating impact on public health and safety in communities across the nation," Gil Kerlikowske, director of the U.S. Office of National Drug Control Policy, said during a Tuesday morning news conference in Washington, D.C. "In 2010, approximately 100 Americans died from overdoses every day," Kerlikowske said. Prescription painkillers were involved in more than 16,600 deaths that year, and heroin was involved in about 3,000 deaths, he added. Overdose ... Read more

Related support groups: Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, Tramadol, OxyContin, Vicodin, Norco, Fentanyl, Morphine, Codeine, Lortab, Opana, Subutex, Dilaudid, Opana ER, Roxicodone, MS Contin, Butrans

Toddlers Can Die From Swallowing Parents' Drug Detox Meds

Posted 29 Aug 2013 by Drugs.com

THURSDAY, Aug. 29 – Children are natural explorers and imitators. But, they don't have the capacity to understand the potential danger in some activities. That helps explain why among 2-year-olds, one of every 180 ends up in the emergency room due to medication poisoning every year. For most children, the outcomes are good. They're treated, and they suffer no lasting damage. But, some drugs can be deadly with only a single dose – including a medication prescribed to help adults combat drug addiction. Buprenorphine is used alone (brand name Subutex) or in combination with another drug called naloxone (brand name Suboxone) to ease the symptoms of withdrawal in people trying to beat addictions to heroin, certain prescription painkillers or other opioid drugs. One dose of this medication can be fatal to a small child. Each year, nearly 1,500 children under 6 years old are treated in U.S. ... Read more

Related support groups: Suboxone, Opiate Dependence, Opiate Withdrawal, Subutex, Butrans, Buprenorphine, Talwin Nx, Narcan, Zubsolv, Buprenex, Naloxone, Buprenorphine/Naloxone, Naloxone/Pentazocine

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Further Information

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Reversal of Opioid Sedation, Opioid Overdose

Related Drug Support Groups

Narcan Injection, Evzio

Naloxone Patient Information at Drugs.com