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FDA Expands Indication For Type 2 Diabetes Treatment Synjardy (Empagliflozin/Metformin Hydrochloride) To Include Treatment-Naïve Adults

Posted 7 days ago by Drugs.com

RIDGEFIELD, Conn., and INDIANAPOLIS, July 19, 2016 /PRNewswire/ – The U.S. Food and Drug Administration has approved an expanded indication for Synjardy (empagliflozin and metformin hydrochloride) tablets to include treatment-naïve adults with type 2 diabetes (T2D). Synjardy, from Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY), is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2D when treatment with both empagliflozin and metformin is appropriate. Synjardy is a combination of empagliflozin (Jardiance) and metformin — two medicines with complementary mechanisms of action — to help control blood glucose in adults with T2D. Empagliflozin, a sodium glucose co-transporter-2 inhibitor, removes excess glucose through the urine by blocking glucose re-absorption in the kidney. Metformin, a commonly prescribed initial treatment for T2D, lowe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Synjardy, Empagliflozin/metformin, Empagliflozin

Which Diabetes Drug Is Best?

Posted 10 days ago by Drugs.com

TUESDAY, July 19, 2016 – No single drug to treat type 2 diabetes stands out from the pack when it comes to reducing the risks of heart disease, stroke or premature death, a new research review finds. The analysis of hundreds of clinical trials found no evidence that any one diabetes drug, or drug combination, beats out the others. Researchers said the results bolster current recommendations to first try an older, cheaper drug – metformin (Glumetza, Glucophage) – for most patients with type 2 diabetes. "There are very few things experts agree on, but this is one of them," said Dr. Kevin Pantalone, a diabetes specialist at the Cleveland Clinic and a member of the Endocrine Society. "Metformin, in the absence of contraindications or intolerability, should be the first-line agent to treat patients with type 2 diabetes," he said. Metformin can cause upset stomach and diarrhea, so some ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Janumet, Glucophage XR, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, ActoPlus Met, Glumetza, Glyburide/Metformin, Avandamet, Janumet XR, Jentadueto, Glucovance, Metformin/Pioglitazone, Fortamet, Kombiglyze XR, Xigduo XR, Riomet, ActosPlus Met

FDA Approves Once-Daily Jentadueto XR (linagliptin and metformin hydrochloride extended-release) for Type 2 Diabetes

Posted 11 Jun 2016 by Drugs.com

Ridgefield, Conn., and Indianapolis, May 31, 2016 – The U.S. Food and Drug Administration (FDA) has approved Jentadueto XR (linagliptin and metformin hydrochloride extended-release) tablets for the treatment of type 2 diabetes (T2D) in adults. Jentadueto XR, which is marketed by Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY), is the seventh new treatment from the Boehringer Ingelheim-Lilly Diabetes alliance to be approved by the FDA in the last five years. Jentadueto XR combines 2.5 mg or 5 mg of linagliptin with 1000 mg of metformin. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing hormones that stimulate the pancreas to produce more insulin and the liver to produce less glucose. Metformin, a commonly prescribed initial treatment for T2D, lowers glucose production by the liver and its absorption in the intestine. “Adults with type 2 diabetes are ... Read more

Related support groups: Diabetes, Type 2, Metformin, Diabetes Mellitus, Jentadueto, Linagliptin, Linagliptin/metformin

Intensive Blood Sugar Control May Be Too Much for Some With Type 2 Diabetes

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests. "In this study, we found that, particularly among older patients and patients with serious chronic conditions, intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author Dr. Rozalina McCoy. She is an endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication of diabetes treatment. The researchers said it can worsen quality of life and has been linked with cardiovascular events, dementia and death. The researchers reviewed information from more than 31,500 American adults. All had stable and controlled type 2 diabetes. None was taking insulin. None had a prior history of severe ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Dementia, Glucophage, Novolog, Glipizide, Humalog, Hypoglycemia, Janumet, Glyburide, Lantus Solostar, Actos, Levemir, Invokana, Glimepiride, Novolin R, Amaryl, Novolin N

FDA Expands Indication of Invokamet (canagliflozin/metformin HCl) to Include First-Line Treatment of Type 2 Diabetes

Posted 31 May 2016 by Drugs.com

RARITAN, N.J., May 24, 2016 – Janssen Pharmaceuticals, Inc. (Janssen), today announced the U.S. Food and Drug Administration (FDA) has approved Invokamet, a fixed-dose combination therapy of INVOKANA® (canagliflozin) and metformin hydrochloride, for first-line treatment of adults with type 2 diabetes. With this new approval, Invokamet may now be prescribed in adults with type 2 diabetes who are not already being treated with canagliflozin or metformin and may benefit from dual therapy.[1] Invokamet, the first combination of a sodium glucose co–transporter 2 (SGLT2) inhibitor and metformin available in the United States, was previously approved by the FDA in August 2014 as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes not adequately controlled by either canagliflozin or metformin, or who are already being treated with both medications sep ... Read more

Related support groups: Diabetes, Type 2, Metformin, Canagliflozin, Invokamet, Canagliflozin/metformin

Coffee, Wine Good for Healthy Gut, Sodas May Be Bad

Posted 28 Apr 2016 by Drugs.com

THURSDAY, April 28, 2016 – The food you eat and the medicines you take can alter your gut bacteria in ways that either help or harm your health, two new studies suggest. Foods like fruits, vegetables, coffee, tea, wine, yogurt and buttermilk can increase the diversity of bacteria in a person's intestines. And that diversity can help ward off illness, said Dr. Jingyuan Fu, senior author of one of the studies. "It is believed that higher diversity and richness [in gut bacteria] is beneficial," explained Fu. She is an associate professor of genetics at the University of Groningen in the Netherlands. On the other hand, foods containing loads of simple carbohydrates appear to reduce bacterial diversity in the gut, Fu and colleagues found. These include high-fat whole milk and sugar-sweetened soda. In addition, medications can also play a part in the makeup of your gut bacteria. Antibiotics, ... Read more

Related support groups: Metformin, Smoking, Heart Attack, Smoking Cessation, Caffeine, Glucophage, Fioricet, Excedrin, Janumet, Alert, Myocardial Infarction, Gastroenteritis, Fiorinal, Excedrin Migraine, Cafergot, Glucophage XR, Esgic, Fiorinal with Codeine, Keep Going, Norgesic

Metformin Safer for Heart Than Other Common Type 2 Diabetes Drugs: Study

Posted 18 Apr 2016 by Drugs.com

MONDAY, April 18, 2016 – Metformin, the most frequently prescribed standalone drug for type 2 diabetes, is better for the heart than its closest competitors, a large analysis suggests. Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report. "Pharmaceutical companies continue to make new drugs to reduce blood sugar and improve on safety concerns of the older drugs," said senior study author Dr. Shari Bolen. But, "while adults with diabetes often need more than one medication to control blood sugar, the newer medications do not appear to be safer than the older drugs," added Bolen. Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Glimepiride, Amaryl, Prevention of Cardiovascular Disease, Glucophage XR, GlipiZIDE XL, Glucotrol, ActoPlus Met, Cardiovascular Risk Reduction, Glucotrol XL, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Glucovance, Jentadueto

Widely Used Type 2 Diabetes Drug May Reduce Cancer Death Risk

Posted 15 Apr 2016 by Drugs.com

FRIDAY, April 15, 2016 – Metformin, a commonly prescribed diabetes drug, may reduce the risk of dying from some cancers for postmenopausal women with type 2 diabetes, a new study suggests. The study found that for women with type 2 diabetes and cancer, the odds of dying from cancer appeared to be 45 percent higher compared to women with cancer who didn't have diabetes. But, in women with cancer who took metformin to treat their type 2 diabetes, the risk of dying from cancer seemed about the same as it was for women without diabetes. "Our findings from this large study may provide more evidence that postmenopausal women with diabetes and cancer may benefit from metformin therapy compared to other anti-diabetes therapy," said lead researcher Zhihong Gong. She's an assistant professor of oncology at the Roswell Park Cancer Institute, in Buffalo, N.Y. Gong cautioned, however, that this ... Read more

Related support groups: Diabetes, Type 2, Cancer, Metformin, Glucophage, Janumet, Glucophage XR, ActoPlus Met, Breast Cancer, Prevention, Glumetza, Glyburide/Metformin, Avandamet, Janumet XR, Jentadueto, Glucovance, Metformin/Pioglitazone, Fortamet, Kombiglyze XR, Xigduo XR, Riomet, ActosPlus Met

FDA Medwatch Alert: Metformin-containing Drugs: Drug Safety Communication - Revised Warnings for Certain Patients With Reduced Kidney Function

Posted 13 Apr 2016 by Drugs.com

ISSUE: FDA is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin’s use in certain patients with reduced kidney function. The current labeling strongly recommends against use of metformin in some patients whose kidneys do not work normally. FDA was asked to review numerous medical studies regarding the safety of metformin use in patients with mild to moderate impairment in kidney function, and to change the measure of kidney function in the metformin drug labeling that is used to determine whether a patient can receive metformin. FDA concluded, from the review of studies published in the medical literature, that metformin can be used safely in patients with mild impairment in kidney function and in some patients with moderate impairment in kidney function. FDA is requiring changes to the metformin labeling to r ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Janumet, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance, Metformin/Pioglitazone, Kombiglyze XR, Fortamet, Xigduo XR, Riomet, Kazano, ActosPlus Met, PrandiMet

Diabetes Cases Quadruple Worldwide Since 1980: Report

Posted 6 Apr 2016 by Drugs.com

WEDNESDAY, April 6, 2016 – The number of adults worldwide with diabetes has quadrupled in the past 35 years, a new report shows. Climbing from 108 million in 1980 to 422 million in 2014, the increases were particularly severe in low- and middle-income countries such as China and India, the researchers noted. Global diabetes rates rose from just over 4 percent to 9 percent among men, and from 5 percent to almost 8 percent among women, the findings showed. The price tag for treating and managing the disease and its complications now totals $825 billion a year, the report found. "Diabetes has become a defining issue for global public health. An aging population, and rising levels of obesity, mean that the number of people with diabetes has increased dramatically," said senior study author Majid Ezzati, a professor at Imperial College, London. The statistics were not divided between type 1 ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Weight Loss, Glucophage, Janumet, Insulin Resistance, Pre-Diabetes, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance, Metformin/Pioglitazone, Abnormal Glucose Tolerance, Fortamet

Cost of Insulin Rises Threefold in Just a Decade: Study

Posted 5 Apr 2016 by Drugs.com

TUESDAY, April 5, 2016 – Americans with diabetes who rely on insulin to keep their blood sugar levels in check are facing sticker shock: A new study finds the price of insulin has tripled in only 10 years. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs, the study found. "The cost of insulin has risen rapidly over the last few years," said study senior author Philip Clarke, a professor of health economics at the University of Melbourne in Australia. Clarke added there should be an assessment to see whether this price hike is justifiable in terms of improved clinical outcomes. One reason for the price climb, he said, is a switch from human insulins to analog insulins, which cost more but may offer additional benefits. Also, doctors are more apt to prescribe insulin for people with type 2 diabetes now, Clarke ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Diabetes, Type 1, Januvia, Glucophage, Diabetic Neuropathy, Novolog, Glipizide, Humalog, Janumet, Byetta, Diabetic Nerve Damage, Insulin Resistance, Glyburide, Lantus Solostar, Bydureon, Actos

Diabetes Meds Vary in Safety and Effectiveness, Study Shows

Posted 31 Mar 2016 by Drugs.com

THURSDAY, March 31, 2016 – A study of nearly a half-million people with type 2 diabetes shows there are pros and cons to nearly every form of drug therapy for the disease. In the British study, researchers looked at patient outcomes from a large U.K. database of almost 470,000 adults with type 2 diabetes, tracked between 2007 and 2015. Julia Hippisley-Cox and Carol Coupland, of the University of Nottingham, sought to parse out differences among a variety of diabetes drugs. They accounted for complicating patient factors such as age, sex, smoking and poverty, as well as how long a person had been diagnosed with type 2 diabetes. The researchers also focused on five major outcomes linked to diabetes: blindness, amputation, severe kidney failure, and high or low blood sugar. Reporting March 30 in BMJ, they found that when a class of drugs called glitazones (Actos, Avandia) was prescribed ... Read more

Related support groups: Diabetes, Type 2, Metformin, Glucophage, Glipizide, Janumet, Insulin Resistance, Glyburide, Actos, Pre-Diabetes, Glimepiride, Amaryl, Diabetes Mellitus, Avandia, Glucophage XR, GlipiZIDE XL, Prandin, Glucotrol, ActoPlus Met, Glucotrol XL, Glumetza

Diabetes Drug May Not Help Obese Women Have Normal-Weight Babies

Posted 3 Feb 2016 by Drugs.com

WEDNESDAY, Feb. 3, 2016 – Giving the diabetes drug metformin to obese pregnant women may not help their newborns come into the world at a healthier weight, a new trial finds. The study, reported Feb. 4 in the New England Journal of Medicine, adds to evidence that metformin does not curb obese women's risk of having an abnormally large newborn. On the other hand, the British researchers found the drug did help control a woman's own weight gain during pregnancy. And it may slash the risk of a potentially dangerous complication called preeclampsia. "Those findings bring to light some potential benefits of metformin for these women," said Dr. Jerrie Refuerzo, an associate professor of obstetrics and gynecology at the University of Texas Health McGovern Medical School, in Houston. For now, diet and exercise will remain the mainstay of managing obesity during pregnancy, according to ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Weight Loss, Glucophage, Janumet, Delivery, Glucophage XR, Vitamin/Mineral Supplementation during Pregnancy/Lactation, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance, Metformin/Pioglitazone, Gestational Diabetes, Fortamet, Kombiglyze XR

Diabetes Drug Improves Gut Bacteria, Study Finds

Posted 4 Dec 2015 by Drugs.com

FRIDAY, Dec. 4, 2015 – The diabetes drug metformin appears to trigger favorable changes in intestinal bacteria, a new study finds. Researchers analyzed the intestinal bacteria populations in 784 people with and without type 2 diabetes who lived in China, Denmark and Sweden. The results showed that taking metformin had positive effects on the intestinal bacteria of people with type 2 diabetes. Specifically, the drug improved the ability of the bacteria to produce certain types of short-chain fatty acids that reduce blood sugar levels in different ways. The researchers also found that patients who take metformin have more coliform bacteria in their intestines, which may explain why the drug causes side effects such as bloating and increased flatulence. "We weren't able to show that other types of antidiabetic drugs had any actual impact on the gut microbiota. When studying type 2 ... Read more

Related support groups: Diabetes, Type 2, Metformin, Irritable Bowel Syndrome, Glucophage, Janumet, Insulin Resistance, Acidophilus, Glucophage XR, Florastor, ActoPlus Met, Glumetza, Glyburide/Metformin, Avandamet, Janumet XR, Jentadueto, Glucovance, Flora-Q, Lactobacillus Acidophilus, Floranex, Metformin/Pioglitazone

Metformin May Not Help Obese Teens With Type 1 Diabetes

Posted 2 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – Metformin is the standby drug for millions of people with type 2 diabetes, but a new study finds that adding it to insulin therapy won't boost blood sugar control for overweight teens with type 1 diabetes. In type 1 diabetes, which comprises about 5 percent of diabetes cases, the body is unable to produce the insulin it needs. So, supplemental insulin is a must for people with the disease. The new study was led by Kellee Miller of the Jaeb Center for Health Research in Tampa, Fla. As her team explained, young people with type 1 diabetes are at even higher metabolic risk if they become overweight or obese, especially in adolescence. That's because both obesity and puberty may cause the patient to require higher levels of supplemental insulin, complicating blood sugar control, the researchers said. Metformin – a pill taken to help lower blood sugar – is widely ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Diabetes, Type 1, Glucophage, Diabetic Neuropathy, Janumet, Diabetic Nerve Damage, Pre-Diabetes, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Glumetza, Glyburide/Metformin, Janumet XR, Avandamet, Jentadueto, Glucovance, Metformin/Pioglitazone, Fortamet

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