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Novo Nordisk Receives FDA Approval for Xultophy 100/3.6 (insulin degludec and liraglutide injection)

Posted 17 days ago by Drugs.com

PLAINSBORO, N.J., Nov. 21, 2016 /PRNewswire/ – Novo Nordisk, a world leader in diabetes care, today announced that the U.S. Food and Drug Administration (FDA) approved the New Drug Application for Xultophy 100/3.6 (insulin degludec 100 units/mL and liraglutide 3.6 mg/mL injection). Xultophy 100/3.6 is a once-daily, combination of Tresiba (insulin degludec injection) and Victoza (liraglutide) injection indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes inadequately controlled on less than 50 units of basal insulin daily or less than or equal to 1.8 mg of liraglutide daily.1 Xultophy 100/3.6 enters into a new class of diabetes treatments that combine a basal insulin and a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in a single, once-daily injection. "Novo Nordisk is committed to discovering and developing new medicines, like ... Read more

Related support groups: Diabetes, Type 2, Victoza, Liraglutide, Tresiba, Insulin Degludec, Xultophy 100/3.6, Insulin Degludec/liraglutide

Intensive Type 2 Diabetes Treatment Can Extend Survival: Study

Posted 8 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 7, 2016 – Intensive management of type 2 diabetes can make a difference in how long and how well you live, even if you don't start until middle age, researchers report. People who were already at risk of type 2 diabetes complications were randomly selected to continue with their normal treatment or to be placed in an aggressive and multipronged treatment group. Two decades after the study began, the researchers found that people in the aggressive treatment group lived almost eight years longer. Not only that, they lived better – their risk of heart disease, kidney disease and blindness all dropped. The only complication that didn't seem to improve was nerve damage caused by diabetes. "Early, intensified intervention in type 2 diabetes patients with microalbuminuria with both target-driven pharmacological (medication) and behavioral actions increased life span. And, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

Diabetes Drug Victoza Might Not Help Advanced Heart Failure Patients

Posted 2 Aug 2016 by Drugs.com

TUESDAY, Aug. 2, 2016 – The diabetes drug liraglutide (Victoza) doesn't appear to improve heart function in patients with advanced heart failure, a new study finds. The theory for this trial was that this drug – from a class of medications called (GLP-1) agonists – might interact with the heart's GLP-1 receptors on cells and thereby improve heart function. "We were hoping for a benefit; we didn't see that. It's at best neutral," said lead researcher Dr. Kenneth Margulies. He's a professor of medicine and research director of heart failure and transplantation at the University of Pennsylvania in Philadelphia. Previous studies found evidence that people with advanced heart failure have insulin resistance of their peripheral muscles and heart muscle, and "this was felt to be a detrimental feature that this type of diabetes medicine might help," he said. Not only did the drug not help, ... Read more

Related support groups: Diabetes, Type 2, Victoza, Heart Failure, Congestive Heart Failure, Insulin Resistance, Saxenda, Pre-Diabetes, Liraglutide, Left Ventricular Dysfunction, Diabetes Mellitus, Abnormal Glucose Tolerance, Left Ventriculography

FDA OKs New Injectable Type 2 Diabetes Medication

Posted 28 Jul 2016 by Drugs.com

THURSDAY, July 28, 2016 – The injectable drug Adlyxin (lixisenatide) has been approved to treat adults with type 2 diabetes, the U.S. Food and Drug Administration says. The once-daily injection is to be used along with diet and exercise to improve patients' blood sugar levels. The FDA reviewed 10 clinical trials on the safety and effectiveness of Adlyxin. These studies included 5,400 people with type 2 diabetes. The drug was also specifically tested for heart issues in an additional 6,000 people at risk of heart disease, the FDA said Thursday in a news release. The FDA concluded that Adlyxin helps normalize blood sugar levels. And it doesn't appear to increase the risk of heart problems. Adlyxin is in a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Other GLP-1 drugs include liraglutide (Victoza), exenatide (Byetta, Bydureon) and dulaglutide (Trulicity), ... Read more

Related support groups: Diabetes, Type 2, Victoza, Insulin Resistance, Byetta, Saxenda, Bydureon, Pre-Diabetes, Trulicity, Liraglutide, Diabetes Mellitus, Exenatide, Abnormal Glucose Tolerance, Dulaglutide, Adlyxin, Lixisenatide

5 Diet Drugs: Which Ones Work?

Posted 14 Jun 2016 by Drugs.com

TUESDAY, June 14, 2016 – Any of the prescription weight-loss drugs on the market can help obese people shed pounds, although some seem more effective than others, a new study finds. Currently, five drugs are approved in the United States for managing obesity. But little has been known about how they stack up against one another, said Dr. Siddharth Singh, the lead researcher on the new study. The findings – based on more than 29,000 people in total – show all five drugs can work. But people on certain drugs tended to be more successful, at least over one year. Specifically, people using Qsymia (phentermine-topiramate) or Victoza (liraglutide) had the highest odds of shedding at least 5 percent of their initial weight. Those taking Xenical (orlistat) had the lowest odds. However, there is no single drug that's "best" for everyone, stressed Singh, an assistant clinical professor at the ... Read more

Related support groups: Obesity, Wellbutrin, Phentermine, Bupropion, Weight Loss, Contrave, Belviq, Wellbutrin XL, Victoza, Adipex-P, Wellbutrin SR, Qsymia, Xenical, Naltrexone, Orlistat, Alli, Saxenda, Zyban, Vivitrol, Liraglutide

Diabetes Drug Victoza May Help the Heart: Study

Posted 14 Jun 2016 by Drugs.com

TUESDAY, June 14, 2016 – The blood sugar-lowering drug Victoza (liraglutide) cuts the risk of heart attack and stroke in type 2 diabetes patients, a new study finds. Heart disease is the leading cause of death among people with type 2 diabetes, the researchers noted. The study was funded by the drug's maker, Novo Nordisk, and the U.S. National Institutes of Health. It included more than 9,300 adults from 32 countries who have type 2 diabetes and a high risk of heart disease. About half took Victoza, while the other half took an inactive placebo. Both groups also took other medications for health problems, such as high blood pressure and high cholesterol, the study authors said. Tracking patients for three years, the researchers found that compared with patients in the placebo group, people who took Victoza had a 13 percent lower risk of heart attack or stroke. They also had a 22 ... Read more

Related support groups: Ischemic Stroke, Heart Attack, Victoza, Saxenda, Transient Ischemic Attack, Myocardial Infarction, Liraglutide, Prevention of Cardiovascular Disease, Ischemic Stroke - Prophylaxis, Cardiovascular Risk Reduction, Myocardial Infarction - Prophylaxis

Cost of Insulin Rises Threefold in Just a Decade: Study

Posted 5 Apr 2016 by Drugs.com

TUESDAY, April 5, 2016 – Americans with diabetes who rely on insulin to keep their blood sugar levels in check are facing sticker shock: A new study finds the price of insulin has tripled in only 10 years. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs, the study found. "The cost of insulin has risen rapidly over the last few years," said study senior author Philip Clarke, a professor of health economics at the University of Melbourne in Australia. Clarke added there should be an assessment to see whether this price hike is justifiable in terms of improved clinical outcomes. One reason for the price climb, he said, is a switch from human insulins to analog insulins, which cost more but may offer additional benefits. Also, doctors are more apt to prescribe insulin for people with type 2 diabetes now, Clarke ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Diabetes, Type 1, Januvia, Glucophage, Novolog, Diabetic Neuropathy, Glipizide, Humalog, Janumet, Insulin Resistance, Diabetic Nerve Damage, Byetta, Saxenda, Glyburide, Bydureon, Lantus Solostar

New Diabetes Cases Among Americans Drop for First Time in Decades: CDC

Posted 1 Dec 2015 by Drugs.com

TUESDAY, Dec. 1, 2015 – In a sign that Americans may finally be turning the corner in the fight against diabetes – and possibly obesity – federal health statistics released Tuesday show that the number of new cases of diabetes has dropped for the first time in decades. The decline wasn't sudden or dramatic. But, the number of new diabetes cases went from 1.7 million in 2009 to 1.4 million in 2014, according to the U.S. Centers for Disease Control and Prevention. "It seems pretty clear that incidence rates have now actually started to drop. Initially it was a little surprising because I had become so used to seeing increases everywhere we looked," CDC researcher Edward Gregg told The New York Times. The proportion of Americans with diabetes is still twice what it was in the early 1990s. And not every racial group has made strides against the blood sugar disease, which is often ... Read more

Related support groups: Diabetes, Type 2, Obesity, Metformin, Insulin, Weight Loss, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Saxenda, Glyburide, Bydureon, Lantus Solostar, Invokana, Levemir

Too Many Seniors With Diabetes Are Overtreated, Study Suggests

Posted 29 Oct 2015 by Drugs.com

THURSDAY, Oct. 29, 2015 – When it comes to treating seniors with diabetes, new research suggests that doctors often don't cut back on medications, even when treatment goals are surpassed. The study found that when people had potentially dangerous low blood sugar levels, just 27 percent had their medicines decreased. And when blood pressure treatments lowered blood pressure levels too much, just 19 percent saw a reduction in their medications. "As people get older, the risks of overtreating become greater, and the benefits become shorter. We have to start emphasizing that more isn't always better," said study author Dr. Jeremy Sussman, an assistant professor of internal medicine at the University of Michigan in Ann Arbor and a primary care doctor at the Ann Arbor VA System. The findings were published online Oct. 26 in the journal JAMA Internal Medicine. Practice guidelines generally ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

Diabetes Drug Might Also Help Some Patients Lose Weight

Posted 18 Aug 2015 by Drugs.com

TUESDAY, Aug. 18, 2015 – High doses of the diabetes drug liraglutide (Victoza) seem to help patients with type 2 diabetes lose weight, a new study suggests. In a trial funded by the drug's maker Novo Nordisk, people who took 3 milligrams (mg) of Victoza daily over 56 weeks lost an average of 6 percent of their body weight (14 pounds). According to Dr. Joel Zonszein, director of the Clinical Diabetes Center at Montefiore Medical Center in New York City, the U.S. Food and Drug Administration has approved the 3 mg-dose for weight loss, but not to treat diabetes. Only lower doses, either 1.2 mg or 1.8 mg a day, have the agency's blessing for treating type 2 diabetes. "This is the first study specifically designed to investigate the efficacy of liraglutide for weight management in patients with type 2 diabetes at a dose of 3 mg, and not surprisingly was found to be effective and tolerated ... Read more

Related support groups: Diabetes, Type 2, Obesity, Weight Loss, Victoza, Saxenda, Liraglutide

Health Tip: Diabetes Can Take a Toll on Teeth and Mouth

Posted 10 Aug 2015 by Drugs.com

-- Diabetes, especially when uncontrolled, can cause damage to your mouth and teeth. The Mouthhealthy.org website says possible effects of diabetes on the teeth and mouth include: Dry mouth, due to decreased saliva production. Increased risk of cavities due to less saliva. Gingivitis, characterized by bleeding, inflamed gums. Difficulty tasting food. Slower healing of mouth wounds. Increased risk of infection. Among diabetic children. teeth emerging earlier than expected. Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Oral and Dental Conditions, Victoza, Xerostomia, Lantus, Toothache, Diabetes, Type 1, Januvia, Glucophage, Novolog, Burning Mouth Syndrome, Diabetic Neuropathy, Glipizide, Humalog, Aphthous Ulcer, Insulin Resistance, Janumet, Diabetic Nerve Damage

People With Type 2 Diabetes Do Benefit From Blood Sugar Checks

Posted 5 Aug 2015 by Drugs.com

WEDNESDAY, Aug. 5, 2015 – Personalized blood sugar self-monitoring benefits people with type 2 diabetes even if they're not taking insulin, a new small study shows. Some experts have questioned the value of self-monitoring in this group, and many insurers – including Medicare – limit the reimbursement of blood sugar (glucose) testing strips to one a day for people with type 2 diabetes. This study included 11 people with type 2 diabetes who worked with the researchers to create personalized, structured self-monitoring blood glucose schedules. In most cases, self-monitoring twice a day was the most helpful in providing meaningful information about blood sugar levels. However, there was room for individualization based on a patient's type of lifestyle and needs. For example, a patient might check their blood sugar twice a day three days a week instead of once a day seven days a week, ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Victoza, Lantus, Januvia, Glucophage, Novolog, Glipizide, Humalog, Janumet, Byetta, Glyburide, Saxenda, Bydureon, Lantus Solostar, Invokana, Levemir, Actos, Glimepiride

Promise From a New Weight-Loss Drug

Posted 1 Jul 2015 by Drugs.com

WEDNESDAY, July 1, 2015 – The injectable drug Saxenda may be a helpful tool in the battle against excess weight and obesity, a new study suggests. People who injected Saxenda (liraglutide) every day for a year lost an average of 18.5 pounds, compared with an average of 6 pounds for those taking a placebo, researchers found. Saxenda "can lower weight, improve cardiovascular risk factors and improve quality of life," said lead researcher Dr. F. Xavier Pi-Sunyer, professor of medicine at Columbia University Medical Center in New York City. "It can also reduce the progression to type 2 diabetes from prediabetes," he said. In a lower-dose version called Victoza, liraglutide is approved for diabetes treatment. For the study, funded by the maker of Saxenda, Novo Nordisk, researchers recruited more than 3,700 overweight or obese people without diabetes . Participants were assigned to daily ... Read more

Related support groups: Obesity, Weight Loss, Victoza, Saxenda, Liraglutide

Experts See Place for Weight-Loss Drugs in Obesity Treatment

Posted 20 Jan 2015 by Drugs.com

TUESDAY, Jan. 20, 2015 – A healthy diet and exercise should be the main tools obese people use to lose weight, but prescription weight-loss drugs may have a place, too, according to new guidelines from the Endocrine Society. "Lifestyle changes should always be a central part of any weight loss strategy," Dr. Caroline Apovian, chair of the guidelines task force, said in a society news release. She is director of the Nutrition and Weight Management Center at Boston Medical Center. The guidelines say that other methods, such as weight-loss drugs and weight-loss surgery, can be combined with lifestyle changes. "Medications do not work by themselves, but they can help people maintain a healthy diet by reducing the appetite. Adding a medication to a lifestyle modification program is likely to result in greater weight loss," said Apovian, who is also professor of medicine and pediatrics at ... Read more

Related support groups: Obesity, Contrave, Belviq, Victoza, Qsymia, Saxenda, Liraglutide, Lorcaserin, Phentermine/topiramate, Bupropion/naltrexone

Diabetes Drug May Spur Weight Loss in Obese Nondiabetics

Posted 30 May 2014 by Drugs.com

THURSDAY, May 29, 2014 – The diabetes drug liraglutide (Victoza) may help obese people without the disease lose weight, a new study suggests. In this test of its effectiveness as a diet aid, people taking Victoza for over a year lost an average of 8 percent of their body weight, compared with 2.6 percent shed by those taking a placebo (dummy drug), researchers found. "Liraglutide, an injection treatment already approved for diabetes treatment, can help reduce body weight in people with obesity when used at a higher dose than is usually used in diabetes," said lead researcher Dr. John Wilding, head of the department of obesity and endocrinology at the University of Liverpool in England. "These results suggest liraglutide is effective and overall well-tolerated for obesity treatment," he said. Although this study didn't compare Victoza with other weight loss drugs, Wilding said that a ... Read more

Related support groups: Obesity, Victoza, Liraglutide

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Weight Loss, Diabetes, Type 2, Obesity

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Liraglutide Patient Information at Drugs.com