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U.S. FDA Approves 72 mcg Dose of Linzess (linaclotide) for Adults with Chronic Idiopathic Constipation

Posted 30 Jan 2017 by Drugs.com

CAMBRIDGE, Mass. and DUBLIN, Jan. 26, 2017 /PRNewswire/ – Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) and Allergan plc (NYSE: AGN) announced today that the U.S. Food and Drug Administration (FDA) has approved a 72 mcg dose of Linzess (linaclotide) for the treatment of chronic idiopathic constipation (CIC) in adult patients. The newly approved dose will provide physicians with dosing flexibility based on individual presentation or tolerability, in treating the large and heterogenous population of adult CIC patients. The new dose is expected to be available in the first quarter of 2017. Linzess is now FDA-approved in three dosage strengths: 290 mcg for adult patients with irritable bowel syndrome with constipation (IBS-C), and 145 mcg and a new 72 mcg for the treatment of adults with CIC. Since the launch of Linzess in December of 2012, nearly 1.5 million unique patients have filled ... Read more

Related support groups: Constipation, Linzess, Constipation - Chronic, Linaclotide

Experts Issue Guidelines for Treating Irritable Bowel Syndrome

Posted 8 Aug 2014 by Drugs.com

FRIDAY, Aug. 8, 2014 – Newly released guidelines for the treatment of irritable bowel syndrome and a type of constipation known as chronic idiopathic constipation reveal a number of proven treatments for these two common conditions. "There's a greater variety of approaches which reflect a greater understanding of the disorders," said guidelines co-author Dr. Eamonn Quigley, chief of the division of gastroenterology and hepatology at Houston Methodist Hospital. "We now have a better opportunity to improve the lives of our patients," Quigley said. The guidelines are published in the August issue of the American Journal of Gastroenterology. An estimated 5 percent to 15 percent of the world's population has irritable bowel syndrome, a condition that can cause symptoms such as abdominal pain, diarrhea or constipation, cramping and bloating, and gas. It can affect people at any age but is ... Read more

Related support groups: Irritable Bowel Syndrome, Linzess, MiraLax, Constipation - Chronic, Dulcolax, Lactulose, Amitiza, Polyethylene Glycol 3350, Xifaxan, Metamucil, Bisacodyl, Rifaximin, Psyllium, Linaclotide, Kristalose, Duphalac, Konsyl, Lubiprostone, ClearLax, Correctol

New Drug Might Help Treat Irritable Bowel Syndrome

Posted 18 Sep 2012 by Drugs.com

TUESDAY, Sept. 18 – A new drug significantly reduces the abdominal pain and constipation characteristic of certain types of irritable bowel syndrome, according to two new studies. Both phase 3 trials, published online Sept. 18 in the American Journal of Gastroenterology, formed much of the basis for approval of the drug, Linzess (linaclotide), by the U.S. Food and Drug Administration in August, said Dr. William Chey, lead author of one of the studies and co-editor-in-chief of the journal. "These are as good a set of results as we've seen on a drug for patients with constipation-predominant irritable bowel syndrome," said Chey, who is a professor of medicine at the University of Michigan Health System, in Ann Arbor. Both trials were funded by Forest Research Institute and Ironwood Pharmaceuticals, Inc., which make the drug. An Ironwood employee provided editorial assistance for both ... Read more

Related support groups: Irritable Bowel Syndrome, Linzess, Linaclotide

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Further Information

Related Condition Support Groups

Constipation - Chronic, Irritable Bowel Syndrome, Constipation

Related Drug Support Groups

Linzess

Linaclotide Patient Information at Drugs.com