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Generic Biologic Drugs Seem as Effective as Originals

Posted 1 Aug 2016 by Drugs.com

MONDAY, Aug. 1, 2016 – Generic biologic drugs are similarly effective to brand-name counterparts in treating rheumatoid arthritis, inflammatory bowel disease and psoriasis, a new study says. Biologics are medications made from living cells. They are complicated to manufacturer and companies that make brand-name versions say cheaper generic versions aren't interchangeable with their products. The patents of many brand-name biologics are expiring and the use of generic versions (called biosimilars) could save patients and the healthcare system significant amounts of money, the Johns Hopkins University researchers noted. "The billion-dollar question has been whether these 'generic biologics' are the same as the brand-name versions," study leader Dr. G. Caleb Alexander, said in a university news release. "The same debate occurred with the advent of less complicated generic drugs and now ... Read more

Related support groups: Rheumatoid Arthritis, Psoriasis, Inflammatory Bowel Disease

Ultrasound Might Speed Up Digestive Drug Delivery: Animal Study

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – Ultrasound waves could be used to rapidly deliver drugs to the digestive system, new animal research suggests. This new approach to drug delivery might potentially benefit people with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. However, this new method of drug delivery hasn't yet been tested in humans. "With additional research, our technology could prove invaluable in both clinical and research settings, enabling improved therapies and expansion of research techniques applied to the [gastrointestinal] tract," said co-senior study author Daniel Blankschtein, a professor of chemical engineering at Massachusetts Institute of Technology (MIT) in Cambridge. "[Our study] demonstrates for the first time the active administration of drugs, including biologics, through the GI tract," he said in an MIT news release. The ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Inflammatory Bowel Disease, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Diagnosis and Investigation

Making Headway Toward Causes of Eczema

Posted 19 Oct 2015 by Drugs.com

MONDAY, Oct. 19, 2015 – New gene variants associated with the skin condition eczema have been identified by an international team of researchers. Eczema, characterized by itchy, red rashes, is known to run in families. The new findings add to the number of genetic variants known to increase risk for the condition, making the total 31. The researchers did this by analyzing the genomes (genetic makeup) of 377,000 people worldwide. "Though the genetic variants identified in this current study represent only a small proportion of the risk for developing eczema ... they do give new insights into important disease mechanisms," said study leader Lavinia Paternoster, an epidemiologist at the University of Bristol in England. "Through ongoing research in this area, these findings could be turned into treatments of the future," she said in a university news release. All of the newly identified ... Read more

Related support groups: Skin Rash, Eczema, Inflammatory Bowel Disease, Minor Skin Conditions

More Evidence High-Fiber, Mediterranean Diet Is Good for You

Posted 29 Sep 2015 by Drugs.com

TUESDAY, Sept. 29, 2015 – Numerous studies have extolled the health benefits of the Mediterranean diet. Now, research suggests the regimen may also boost levels of beneficial fatty acids. These so-called "short chain fatty acids" are produced by bacteria in the intestine during fermentation of insoluble fiber from fruits, vegetables and legumes. The fatty acids are believed to provide a number of health benefits, including a lower risk of diabetes, heart disease and inflammatory diseases, an Italian team reports in the Sept. 29 issue of the journal Gut. "We provide here tangible evidence of the impact of a healthy diet and a Mediterranean dietary pattern," wrote the team led by Danilo Ercolini, a professor of microbiology at the University of Naples in Italy. The study of 153 Italian adults found higher levels of short chain fatty acids in vegans, vegetarians and those who closely ... Read more

Related support groups: Diabetes, Type 2, Heart Disease, Crohn's Disease, Ulcerative Colitis, Fish Oil, Lovaza, Inflammatory Bowel Disease, Omega-3, Dietary Fiber Supplementation, Omacor, Omega-3 Polyunsaturated Fatty Acids, MaxEPA, Animi-3, Marine Lipid Concentrate, Omega 3-6-9 Complex, EPA Fish Oil, Restora, Omtryg, TheraTears Nutrition, Divista

Health Tip: Should I Talk to my Doctor About Gas?

Posted 10 Aug 2015 by Drugs.com

-- While everyone has intestinal gas, some people have severe bloating that causes discomfort and other problems. The Mayo Clinic mentions these warning signs that you may need to see a doctor: Intestinal gas that is persistent and severe. Intestinal gas that occurs with vomiting. Long-term diarrhea, bloody stool or constipation. Weight loss for no apparent reason. Heartburn. Read more

Related support groups: GERD, Diarrhea, Constipation, Gas, Abdominal Distension, Weight Loss, Colitis, Indigestion, Constipation - Chronic, Hemorrhoids, Gastrointestinal Disorders, Inflammatory Bowel Disease, Constipation - Acute, Duodenitis/Gastritis, Anal Fissure and Fistula, Diarrhea, Chronic, Diarrhea, Acute, Infectious Diarrhea, Acute Abdomen, Functional Gastric Disorder

Severe Burns May Trigger Dangerous Shifts in Gut Germs

Posted 8 Jul 2015 by Drugs.com

WEDNESDAY, July 8, 2015 – People who suffer severe burns may experience potentially dangerous changes in the 100 trillion bacteria inside their gastrointestinal (GI) tract, a small study suggests. At issue is the breakdown of good and bad bacteria typically found inside a healthy person's GI tract. Researchers from the health sciences division of Loyola University Chicago in Maywood, Ill., observed that after a severe burn, four patients experienced a big increase in the number of potentially harmful bacteria and a corresponding drop in relatively beneficial bacteria. The potentially harmful bacteria are part of a family that includes E. coli and salmonella. Such an imbalance, known as "dysbiosis," has been linked to many conditions, including inflammatory bowel disease, obesity, rheumatoid arthritis and diabetes, study lead author Dr. Mashkoor Choudhry, a professor of surgical ... Read more

Related support groups: Diabetes, Type 2, Obesity, Rheumatoid Arthritis, Gastrointestinal Disorders, Inflammatory Bowel Disease, Burns - External, Burns, Nitrogen Retention

Slowed Growth Could Signal Crohn's Disease in Kids

Posted 18 Mar 2015 by Drugs.com

WEDNESDAY, March 18, 2015 – A lag in growth could be a sign that a child might suffer from undiagnosed inflammatory bowel disease (IBD), especially Crohn's disease, one pediatric doctor says. "Growth charts are one of the most important things we look at with children because sometimes a slower growth rate is the only sign of IBD, especially with Crohn's disease," Dr. Marc Schaefer, a pediatric gastroenterologist, said in a Penn State University news release. Other symptoms of inflammatory bowel disease in children include not wanting to eat, persistent stomach pains, and diarrhea or bloody stools, said Schaefer, who works at Penn State Hershey Children's Hospital in Hershey, Pa. Children with these symptoms should be evaluated, he suggested. Blood tests and endoscopy are also used to diagnose and to distinguish Crohn's from ulcerative colitis, another type of inflammatory bowel ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Growth Retardation

Additives in Processed Foods May Alter Gut Bacteria

Posted 25 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 25, 2015 – A common ingredient in many processed foods might increase the risk of inflammatory bowel disease (IBD) and metabolic syndrome, a new study in mice suggests. Emulsifiers are used to improve food texture and to extend shelf life. In experiments with mice, researchers found that emulsifiers can alter the make-up of bacteria populations in the digestive tract. This can lead to inflammation that may contribute to the development of IBD and metabolic syndrome, the researchers said. IBD – which includes Crohn's disease and ulcerative colitis – affects millions of people and is often severe and debilitating, according to the researchers. Metabolic syndrome is a group of obesity-related conditions that can lead to diabetes, as well as heart and/or liver diseases. But, it's important to note that this study was conducted in mice, and research done in mice doesn't ... Read more

Related support groups: Obesity, Insulin Resistance, Inflammatory Bowel Disease

Mercury in Seafood May Raise Risk of Autoimmune Diseases in Women: Study

Posted 10 Feb 2015 by Drugs.com

TUESDAY, Feb. 10, 2015 – The mercury found in some seafood may be linked to autoimmune disorders among women of childbearing age, new research suggests. Autoimmune diseases develop when the body's immune response goes awry and starts to attack healthy cells. Such diseases include lupus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and "Sjogren's syndrome." All told, these diseases affect roughly 50 million Americans, most of whom are women, the University of Michigan researchers said. "We don't have a very good sense of why people develop autoimmune disorders," study author Emily Somers said in a university news release. "A large number of cases are not explained by genetics," she added, "so we believe studying environmental factors will help us understand why autoimmunity happens and how we may be able to intervene to improve health outcomes. In our study, ... Read more

Related support groups: Rheumatoid Arthritis, Multiple Sclerosis, Systemic Lupus Erythematosus, Autoimmune Disorders, Sjogren's Syndrome, Inflammatory Bowel Disease, Lupus Erythematosus, Mercury Poisoning

Crohn's, Colitis May Have Genetic Underpinnings, Study Finds

Posted 19 Dec 2014 by Drugs.com

FRIDAY, Dec. 19, 2014 – The intestinal bacteria that cause inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, may be inherited, researchers report. The findings, published recently in the journal Genome Medicine, could help in efforts to prevent the disease and treat the 1.6 million Americans with Crohn's or colitis, the study authors added. "The intestinal bacteria, or 'gut microbiome,' you develop at a very young age can have a big impact on your health for the rest of your life," lead author Dan Knights, an assistant professor in the department of computer science and engineering and the Biotechnology Institute at the University of Minnesota, said in a journal news release. "We have found groups of genes that may play a role in shaping the development of imbalanced gut microbes," he explained. The study of 474 adults with inflammatory bowel disease ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Pseudomembranous Colitis

Certain Autoimmune Drugs in Pregnancy May Up Newborn Infection Risk: Study

Posted 3 Oct 2014 by Drugs.com

FRIDAY, Oct. 3, 2014 – When given to pregnant women, a common treatment for ulcerative colitis may inadvertently lower their baby's ability to fight off infections at birth, new French research suggests. The treatment, called anti-TNF therapy, is an injected, artificial antibody. This type of medication is widely seen as a safe and effective way to tackle a wide range of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel conditions that include ulcerative colitis and Crohn's disease. It's not unusual for pregnant women to receive the treatment, given that inflammatory bowel diseases often strike women of childbearing age. However, this type of drug can cross the placenta and reach the fetus, the study authors said. And four French cases – all involving babies born to women exposed to Remicade (infliximab) during pregnancy – suggest the therapy may cause newborn ... Read more

Related support groups: Rheumatoid Arthritis, Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Inflammatory Bowel Disease, Cimzia, Simponi, Infliximab, Adalimumab, Etanercept, Certolizumab, Golimumab

Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study

Posted 18 Jun 2014 by Drugs.com

WEDNESDAY, June 18, 2014 – A popular class of drugs used to treat inflammatory bowel disease isn't linked to an increase in the short-term risk of cancer, Danish researchers report. Researchers found that people with Crohn's disease or colitis who received the drugs – tumor necrosis factor alpha (TNF-a) antagonists – had about the same risk of cancer as other people with these inflammatory bowel diseases who were not treated with the medication. The drugs work by interrupting the function of TNF-a, a substance used by the immune system to increase inflammation. "Treatment with these drugs inhibits the inflammatory response in the gastrointestinal tract thereby leading to reduced symptoms," said lead author Dr. Nynne Nyboe Andersen of the Statens Serum Institute in Copenhagen. The problem is that TNF-a also serves a key role in protecting the body against cancer, raising concerns that ... Read more

Related support groups: Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Colorectal Cancer, Inflammatory Bowel Disease, Cimzia, Simponi, Infliximab, Adalimumab, Etanercept, Certolizumab, Golimumab

Drug Shows Promise for People With Colitis, Crohn's Disease

Posted 21 Aug 2013 by Drugs.com

WEDNESDAY, Aug. 21 – An experimental drug may help some people who have inflammatory bowel disease that has failed to respond to current medications, two new clinical trials find. The drug, called vedolizumab, is being developed to treat the two main forms of inflammatory bowel disease (IBD) – ulcerative colitis and Crohn's disease. Both arise when the immune system launches an abnormal attack on the lining of the digestive tract, leading to chronic inflammation and symptoms such as abdominal cramps, diarrhea and rectal bleeding. In the new trials, reported in the Aug. 22 issue of the New England Journal of Medicine, researchers found that vedolizumab worked in some cases where standard IBD medications had failed. The drug was more effective for colitis than for Crohn's, however, and an expert not involved in the studies said he suspects vedolizumab might be approved for colitis ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis

Posted 20 Feb 2013 by Drugs.com

WEDNESDAY, Feb. 20 – A new study counters the notion that the prescription acne drug Accutane raises the risk of Crohn's disease or colitis in women. The study of more than 45,000 women found no such link between Accutane (isotretinoin) use and these illnesses, which are collectively known as inflammatory bowel disease (IBD). One expert not connected to the study called it a "welcome review." "There has been a lot of speculation and even litigation that Accutane causes inflammatory bowel disease," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City. "Dermatologists have been discouraged from using Accutane and the makers of Accutane have discontinued their production due to countless lawsuits," she noted, but "this study once again highlights the safety of Accutane." Ulcerative colitis and Crohn's disease are the most common forms of IBD, a group of ... Read more

Related support groups: Acne, Accutane, Crohn's Disease, Colitis, Isotretinoin, Claravis, Inflammatory Bowel Disease, Amnesteem, Sotret, Absorica, Myorisan

Gene Study Yields New Clues to Crohn's Disease, Colitis

Posted 31 Oct 2012 by Drugs.com

WEDNESDAY, Oct. 31 – Scientists say research into the genetics of inflammatory bowel disease – which includes Crohn's disease and ulcerative colitis – is revealing new insights into the origin of this set of illnesses. The researchers said they have linked genetic variations in 163 regions of the human genome with a heightened risk of developing inflammatory bowel disease (IBD). Of those regions, 71 are newly discovered. IBD comprises a group of chronic, autoimmune digestive disorders that affect 2.5 million people worldwide. Symptoms include abdominal pain and diarrhea and patients typically require lifelong treatment with drug therapy. Many also require surgery to repair tissue damage caused by the disease. In this study, researchers analyzed data from about 34,000 people who took part in 15 previous studies of either Crohn's disease or ulcerative colitis. They also examined data ... Read more

Related support groups: Crohn's Disease, Colitis, Inflammatory Bowel Disease

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