| Rank |
Drug |
Current Manufacturer |
Total Sales ($000) |
% Change 2005 |
| 1 |
Lipitor
| Pfizer Inc |
6,577,810 |
4.1% |
| 2 |
Nexium
| AstraZeneca Pharmaceuticals |
4,060,286 |
18.1% |
| 3 |
Prevacid
| Takeda Pharmaceuticals North America, Inc |
3,305,778 |
-0.7% |
4 ( 1) |
Advair Diskus
| GlaxoSmithKline |
3,105,780 |
9.7% |
5 ( 4) |
Singulair
| Merck & Co., Inc. |
2,460,929 |
17.8% |
6 ( 2) |
Effexor XR
| Wyeth |
2,246,965 |
1.2% |
| 7 |
Plavix
| Bristol-Myers Squibb Company |
2,231,825 |
-10.0% |
8 ( 4) |
Zocor
| Merck & Co., Inc. |
2,171,312 |
-30.1% |
9 ( 1) |
Norvasc
| Pfizer Inc |
2,149,017 |
4.3% |
10 ( 3) |
Lexapro
| Forest Pharmaceuticals, Inc |
2,098,794 |
13.5% |
11 ( 3) |
Seroquel
| AstraZeneca Pharmaceuticals |
2,074,734 |
20.7% |
12 ( 1) |
Protonix
| Wyeth |
2,020,865 |
3.2% |
13 ( 1) |
Ambien
| Pfizer Inc |
1,938,649 |
0.3% |
14 ( 1) |
Actos
| Takeda Pharmaceuticals North America, Inc |
1,926,293 |
20.0% |
15 ( 9) |
Zoloft
| Pfizer Inc |
1,772,599 |
-30.8% |
16 ( 5) |
Wellbutrin XL
| Valeant Pharmaceuticals International |
1,670,516 |
26.0% |
17 ( 2) |
Avandia
| GlaxoSmithKline |
1,664,459 |
20.5% |
| 18 |
Risperdal
| Janssen Pharmaceuticals, Inc |
1,656,891 |
12.5% |
19 ( 3) |
Zyprexa
| Eli Lilly and Company |
1,536,167 |
-2.6% |
20 ( 5) |
Topamax
| Janssen Pharmaceuticals, Inc |
1,520,472 |
19.9% |
21 ( 2) |
Toprol XL
| AstraZeneca Pharmaceuticals |
1,471,881 |
13.7% |
22 ( 27) |
Vytorin
| Merck & Co., Inc. |
1,469,209 |
105.4% |
23 ( 6) |
Fosamax
| Merck & Co., Inc. |
1,427,165 |
-3.8% |
24 ( 5) |
Abilify
| Bristol-Myers Squibb Company |
1,417,106 |
29.0% |
25 ( 5) |
Levaquin
| Janssen Pharmaceuticals, Inc |
1,409,195 |
4.5% |
26 ( 8) |
Lamictal
| GlaxoSmithKline |
1,326,844 |
28.7% |
27 ( 1) |
Celebrex
| Pfizer Inc |
1,326,177 |
6.0% |
| 28 |
Lotrel
| Novartis Corporation |
1,292,863 |
16.5% |
29 ( 2) |
Zyrtec
| Johnson & Johnson |
1,163,312 |
10.0% |
30 ( 11) |
Coreg
| GlaxoSmithKline |
1,158,322 |
36.8% |
31 ( 5) |
Valtrex
| GlaxoSmithKline |
1,150,247 |
17.6% |
32 ( 7) |
Zetia
| Schering-Plough |
1,139,638 |
26.0% |
33 ( 2) |
Adderall XR
| Shire US Inc |
1,131,834 |
12.3% |
34 ( 2) |
Aciphex
| Eisai Corporation |
1,113,022 |
6.2% |
35 ( 26) |
Cymbalta
| Eli Lilly and Company |
1,084,313 |
90.1% |
36 ( 9) |
Enbrel
| Amgen Inc. |
1,084,243 |
-4.1% |
37 ( 14) |
Crestor
| AstraZeneca Pharmaceuticals |
1,058,160 |
56.3% |
38 ( 8) |
Lantus
| Sanofi-Aventis |
1,057,914 |
36.6% |
39 ( 4) |
Diovan
| Novartis Corporation |
972,055 |
19.9% |
40 ( 5) |
Tricor
| Abbott Laboratories |
965,680 |
22.4% |
41 ( 1) |
Concerta
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
936,240 |
8.1% |
42 ( 6) |
Diovan HCT
| Novartis Corporation |
866,738 |
19.7% |
43 ( 1) |
Imitrex Oral
| GlaxoSmithKline |
858,252 |
4.6% |
44 ( 8) |
Aricept
| Eisai Corporation |
799,967 |
22.7% |
45 ( 10) |
Nasonex
| Schering-Plough |
788,998 |
26.9% |
46 ( 1) |
Viagra
| Pfizer Inc |
786,142 |
1.8% |
47 ( 12) |
Flomax
| Boehringer Ingelheim Pharmaceuticals, Inc |
785,626 |
34.7% |
48 ( 4) |
Actonel
| Procter & Gamble |
780,529 |
-1.5% |
49 ( 9) |
Omnicef
| Abbott Laboratories |
772,826 |
27.2% |
| 50 |
Altace
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
717,207 |
2.4% |
51 ( 27) |
OxyContin
| Purdue Pharma LP |
682,904 |
-46.9% |
52 ( ) |
Lyrica
| Pfizer Inc |
650,944 |
930.3% |
53 ( 11) |
Zofran
| GlaxoSmithKline |
645,411 |
16.3% |
54 ( 14) |
Provigil
| Cephalon, Inc. |
644,528 |
29.7% |
55 ( 16) |
Lidoderm
| Endo Pharmaceuticals |
635,892 |
35.1% |
56 ( 4) |
Cozaar
| Merck & Co., Inc. |
618,670 |
6.6% |
| 57 |
Lamisil Oral
| Novartis Corporation |
613,006 |
0.7% |
58 ( 19) |
Lovenox
| Sanofi-Aventis |
596,680 |
36.0% |
59 ( 38) |
Spiriva
| Boehringer Ingelheim Pharmaceuticals, Inc |
593,334 |
75.6% |
60 ( 5) |
Detrol LA
| Pfizer Inc |
584,532 |
9.3% |
61 ( 56) |
Lunesta
| Sepracor Inc. (renamed Sunovion Pharmaceuticals Inc) |
583,556 |
120.8% |
62 ( 8) |
Synthroid
| Abbott Laboratories |
579,742 |
-9.4% |
63 ( 10) |
Strattera
| Eli Lilly and Company |
577,944 |
-10.0% |
64 ( 8) |
Premarin Tabs
| Wyeth |
576,358 |
-6.5% |
65 ( 43) |
Pravachol
| Bristol-Myers Squibb Company |
575,985 |
-56.2% |
66 ( 33) |
Truvada
| Gilead Sciences, Inc. |
569,618 |
74.4% |
67 ( ) |
Ambien CR
| Sanofi-Aventis |
552,980 |
>999 |
68 ( 21) |
Actiq
| Abbott Laboratories |
546,427 |
47.4% |
69 ( 6) |
Depakote
| Abbott Laboratories |
542,016 |
-3.8% |
70 ( 3) |
Combivent
| Boehringer Ingelheim Pharmaceuticals, Inc |
534,477 |
6.6% |
71 ( 1) |
Humalog
| Eli Lilly and Company |
533,683 |
10.1% |
72 ( 9) |
Geodon Oral
| Pfizer Inc |
529,350 |
24.8% |
73 ( 4) |
Pulmicort Respules
| AstraZeneca Pharmaceuticals |
520,747 |
7.1% |
74 ( 1) |
Trileptal
| Novartis Corporation |
513,429 |
12.0% |
75 ( 37) |
Mobic
| Abbott Laboratories |
512,978 |
-44.0% |
| 76 |
Yasmin 28
| Bayer Healthcare Pharmaceuticals |
508,160 |
15.2% |
77 ( 11) |
Evista
| Eli Lilly and Company |
507,954 |
0.6% |
78 ( 6) |
CellCept
| Roche Pharmaceuticals |
507,652 |
9.9% |
79 ( 5) |
Humira
| Abbott Laboratories |
505,566 |
28.0% |
80 ( 1) |
Depakote ER
| Abbott Laboratories |
501,961 |
17.2% |
81 ( 7) |
Keppra
| UCB Inc. |
498,913 |
31.4% |
82 ( 7) |
Skelaxin
| Elan Corporation |
482,964 |
8.4% |
83 ( 26) |
Flovent HFA
| GlaxoSmithKline |
476,624 |
64.6% |
84 ( 10) |
Hyzaar
| Merck & Co., Inc. |
474,967 |
6.0% |
85 ( 2) |
Niaspan
| Abbott Laboratories |
473,755 |
24.4% |
86 ( 8) |
Prograf
| Astellas Pharma US |
446,139 |
3.4% |
87 ( 6) |
Arimidex
| AstraZeneca Pharmaceuticals |
446,009 |
28.2% |
88 ( 3) |
Procrit
| Centocor Ortho Biotech, Inc |
418,431 |
6.3% |
89 ( 11) |
Zelnorm
| Novartis Corporation |
417,116 |
31.1% |
90 ( 8) |
Xalatan
| Pfizer Inc |
403,790 |
-1.3% |
91 ( 5) |
Asacol
| Procter & Gamble |
388,196 |
14.5% |
92 ( 20) |
Namenda
| Forest Pharmaceuticals, Inc |
386,739 |
36.5% |
93 ( 13) |
Cialis
| Eli Lilly and Company |
375,143 |
27.1% |
94 ( 7) |
Reyataz
| Bristol-Myers Squibb Company |
372,790 |
18.8% |
| 95 |
Ortho Tri-Cyclen Lo
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
371,803 |
9.6% |
96 ( 4) |
Avapro
| Bristol-Myers Squibb Company |
367,239 |
4.7% |
97 ( ) |
Byetta
| Amylin Pharmaceuticals, Inc. |
362,996 |
632.3% |
98 ( 36) |
Duragesic
| |
357,439 |
-37.3% |
99 ( 13) |
Combivir
| GlaxoSmithKline |
355,848 |
-9.4% |
100 ( 11) |
Kaletra
| Abbott Laboratories |
352,013 |
23.6% |
101 ( 14) |
Gleevec
| Novartis Corporation |
338,139 |
24.8% |
102 ( 20) |
Avelox
| Bayer Healthcare Pharmaceuticals |
335,397 |
29.3% |
103 ( 20) |
Allegra-D 12 Hour
| Sanofi-Aventis |
335,011 |
-15.8% |
104 ( 27) |
Benicar HCT
| Daiichi Sankyo |
333,894 |
46.8% |
105 ( 7) |
Paxil CR
| Apotex Corp |
327,010 |
-1.5% |
106 ( 15) |
Clarinex
| Schering-Plough |
321,246 |
-9.1% |
| 107 |
Xopenex
| Sepracor Inc. (renamed Sunovion Pharmaceuticals Inc) |
320,084 |
9.2% |
108 ( 18) |
Benicar
| Daiichi Sankyo |
312,791 |
24.4% |
109 ( 1) |
Copaxone
| Sanofi-Aventis |
305,828 |
7.0% |
110 ( 7) |
Sustiva
| Bristol-Myers Squibb Company |
300,944 |
-2.7% |
111 ( 5) |
Avalide
| Bristol-Myers Squibb Company |
300,774 |
12.2% |
112 ( 10) |
Nasacort AQ
| Sanofi-Aventis |
299,484 |
-3.8% |
113 ( 8) |
AndroGel
| Abbott Laboratories |
295,593 |
13.3% |
114 ( 4) |
Forteo
| Eli Lilly and Company |
295,172 |
11.9% |
115 ( 2) |
Patanol
| Alcon Laboratories, Inc. |
290,912 |
4.8% |
116 ( 8) |
Avonex
| Biogen Idec |
289,082 |
-1.2% |
117 ( 84) |
Flonase
| GlaxoSmithKline |
285,179 |
-72.7% |
118 ( 16) |
Thalomid
| Celgene Corporation |
273,921 |
25.7% |
119 ( ) |
Boniva
| Genentech, Inc |
270,321 |
387.8% |
120 ( 16) |
Zofran ODT
| GlaxoSmithKline |
267,379 |
24.9% |
121 ( 76) |
Caduet
| Pfizer Inc |
266,446 |
91.3% |
122 ( ) |
Requip
| GlaxoSmithKline |
260,813 |
139.5% |
123 ( 10) |
Fuzeon
| Roche Pharmaceuticals |
256,183 |
15.8% |
124 ( 20) |
Rhinocort Aqua
| AstraZeneca Pharmaceuticals |
254,697 |
-14.1% |
125 ( 5) |
Norvir
| Abbott Laboratories |
249,522 |
8.0% |
126 ( 55) |
Tarceva
| Genentech, Inc |
245,470 |
64.2% |
127 ( 22) |
Ditropan XL
| Janssen Pharmaceuticals, Inc |
244,579 |
-17.4% |
128 ( 4) |
Aldara
| Medicis Pharmaceutical Corporation |
242,947 |
7.1% |
129 ( 46) |
NovoLog Mix 70/30
| Novo Nordisk Inc. |
238,014 |
53.5% |
130 ( 24) |
Femara
| Novartis Corporation |
237,495 |
37.0% |
131 ( 51) |
Ortho Evra
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
232,914 |
-45.2% |
132 ( 18) |
Endocet
| Endo Pharmaceuticals |
226,805 |
25.3% |
133 ( 13) |
RenaGel
| Genzyme Corporation |
226,128 |
22.2% |
134 ( 9) |
Cosopt
| Merck & Co., Inc. |
223,797 |
17.5% |
135 ( 21) |
Viread
| Gilead Sciences, Inc. |
223,659 |
-17.7% |
136 ( 11) |
Trizivir
| GlaxoSmithKline |
222,562 |
-12.3% |
137 ( 8) |
Budeprion SR
| Teva Pharmaceuticals |
211,097 |
-10.0% |
138 ( 50) |
Restasis
| Allergan, Inc |
208,568 |
42.3% |
139 ( 29) |
Zyvox
| Pfizer Inc |
204,629 |
26.1% |
140 ( 29) |
Relpax
| Pfizer Inc |
204,508 |
26.2% |
141 ( 20) |
Lumigan
| Allergan, Inc |
203,641 |
21.3% |
142 ( 2) |
BenzaClin
| Sanofi-Aventis |
203,033 |
2.2% |
143 ( 2) |
Humalog Mix 75/25 Pn
| |
200,266 |
3.9% |
144 ( 50) |
Zithromax Susp
| |
198,939 |
-41.9% |
145 ( 10) |
Mirapex
| Boehringer Ingelheim Pharmaceuticals, Inc |
197,457 |
15.0% |
146 ( ) |
Avodart
| GlaxoSmithKline |
192,791 |
99.7% |
147 ( 15) |
Casodex
| AstraZeneca Pharmaceuticals |
192,647 |
15.0% |
148 ( 44) |
Astelin
| Meda Pharmaceuticals |
186,944 |
29.6% |
149 ( 37) |
Vigamox
| Alcon Laboratories, Inc. |
181,807 |
23.3% |
150 ( ) |
Epzicom
| GlaxoSmithKline |
181,391 |
64.2% |
151 ( 13) |
Lescol XL
| Novartis Corporation |
180,223 |
-13.6% |
152 ( 18) |
Xeloda
| Genentech, Inc |
179,612 |
10.9% |
153 ( 4) |
Tussionex
| Sanofi-Aventis |
179,383 |
-1.2% |
154 ( 17) |
Coumadin Tabs
| Bristol-Myers Squibb Company |
178,711 |
-14.8% |
155 ( ) |
Sensipar
| Amgen Inc. |
177,838 |
89.1% |
156 ( 38) |
Levitra
| Bayer Healthcare Pharmaceuticals |
177,367 |
25.3% |
157 ( 2) |
Temodar
| Schering-Plough |
177,089 |
5.2% |
158 ( 6) |
Inderal LA
| Wyeth |
175,218 |
-1.4% |
159 ( 12) |
Prilosec
| AstraZeneca Pharmaceuticals |
174,624 |
-5.1% |
160 ( 7) |
Catapres-TTS
| Boehringer Ingelheim Pharmaceuticals, Inc |
174,137 |
6.8% |
161 ( ) |
NuvaRing
| Merck & Co., Inc. |
173,168 |
55.0% |
162 ( 38) |
Biaxin XL
| Abbott Laboratories |
171,873 |
-32.6% |
163 ( 18) |
Zyrtec Syrup
| |
171,381 |
-8.2% |
164 ( 16) |
Alphagan P
| Allergan, Inc |
169,571 |
-7.5% |
165 ( 9) |
Differin
| Galderma Laboratories |
168,884 |
0.0% |
166 ( 1) |
Zyrtec-D
| Pfizer Inc |
168,028 |
2.7% |
167 ( 7) |
Tobradex
| Alcon Laboratories, Inc. |
166,663 |
7.5% |
168 ( 19) |
Aranesp
| Amgen Inc. |
166,443 |
13.2% |
169 ( 16) |
Klor-Con
| Upsher-Smith Laboratories Inc. |
163,286 |
-7.1% |
170 ( 12) |
Humulin N
| Eli Lilly and Company |
163,208 |
-3.1% |
| 171 |
DuoNeb
| Dey Pharma |
162,376 |
0.7% |
172 ( 6) |
Famvir
| GlaxoSmithKline |
160,602 |
-1.7% |
173 ( 45) |
Proscar
| Merck & Co., Inc. |
160,135 |
-33.0% |
174 ( 8) |
Neupogen
| Amgen Inc. |
159,279 |
7.1% |
175 ( 48) |
Elidel
| Novartis Corporation |
159,248 |
-36.4% |
176 ( ) |
Focalin XR
| Novartis Corporation |
159,008 |
320.2% |
177 ( 35) |
Levoxyl
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
158,100 |
-17.4% |
| 178 |
Betaseron
| Bayer Healthcare Pharmaceuticals |
157,966 |
3.9% |
179 ( ) |
Ciprodex Otic
| Alcon Laboratories, Inc. |
157,513 |
20.1% |
180 ( 36) |
Trinessa
| Watson Pharmaceuticals, Inc. |
157,403 |
-15.8% |
181 ( 2) |
Atacand
| AstraZeneca Pharmaceuticals |
156,519 |
5.4% |
182 ( 18) |
Pegasys
| Genentech, Inc |
154,897 |
-5.8% |
183 ( ) |
Kadian
| Actavis |
154,653 |
40.5% |
184 ( 21) |
Arthrotec
| Pfizer Inc |
152,627 |
-7.3% |
185 ( ) |
Aggrenox
| Boehringer Ingelheim Pharmaceuticals, Inc |
151,976 |
20.1% |
186 ( 7) |
Humulin 70/30
| Eli Lilly and Company |
149,664 |
5.1% |
187 ( 13) |
Avinza
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
149,425 |
10.7% |
188 ( 2) |
Pulmozyme
| Genentech, Inc |
145,461 |
-0.4% |
189 ( ) |
Travatan
| Alcon Laboratories, Inc. |
144,801 |
24.4% |
190 ( ) |
Maxalt
| Merck & Co., Inc. |
144,387 |
17.7% |
191 ( ) |
Dovonex
| Bristol-Myers Squibb Company |
143,568 |
7.9% |
192 ( ) |
Risperdal Consta
| Janssen Pharmaceuticals, Inc |
142,446 |
28.2% |
193 ( ) |
Tri-Sprintec
| |
140,810 |
9.7% |
194 ( 5) |
Zomig
| AstraZeneca Pharmaceuticals |
140,265 |
-4.0% |
195 ( ) |
Maxalt MLT
| |
140,005 |
12.4% |
196 ( 2) |
Prempro
| Pfizer Inc |
138,795 |
1.6% |
197 ( 58) |
Augmentin XR
| Dr. Reddy's Laboratories Inc. |
138,544 |
-32.8% |
198 ( ) |
Suboxone
| Reckitt Benckiser Pharmaceuticals Inc. |
137,067 |
93.5% |
199 ( 79) |
Avandamet
| GlaxoSmithKline |
136,470 |
-47.9% |
200 ( ) |
Fosamax Plus D
| Merck & Co., Inc. |
136,034 |
506.5% |
|
All Others |
|
23,603,372 |
-12.7% |