| Rank |
Drug |
Current Manufacturer |
Total Sales ($000) |
% Change 2004 |
| 1 |
Lipitor
| Pfizer Inc |
6,320,522 |
6.0% |
2 ( 2) |
Nexium
| AstraZeneca Pharmaceuticals |
3,436,794 |
16.0% |
3 ( 1) |
Prevacid
| Takeda Pharmaceuticals North America, Inc |
3,327,919 |
4.1% |
4 ( 1) |
Zocor
| Merck & Co., Inc. |
3,106,628 |
-1.4% |
5 ( 1) |
Advair Diskus
| GlaxoSmithKline |
2,830,047 |
21.8% |
6 ( 1) |
Zoloft
| Pfizer Inc |
2,561,069 |
-2.4% |
7 ( 1) |
Plavix
| Bristol-Myers Squibb Company |
2,480,042 |
14.3% |
8 ( 1) |
Effexor XR
| Wyeth |
2,219,469 |
-2.7% |
9 ( 5) |
Singulair
| Merck & Co., Inc. |
2,089,348 |
13.0% |
10 ( 2) |
Norvasc
| Pfizer Inc |
2,060,364 |
9.4% |
| 11 |
Protonix
| Wyeth |
1,957,950 |
2.5% |
12 ( 3) |
Ambien
| Pfizer Inc |
1,932,940 |
12.4% |
13 ( 4) |
Lexapro
| Forest Pharmaceuticals, Inc |
1,849,528 |
19.2% |
14 ( 8) |
Seroquel
| AstraZeneca Pharmaceuticals |
1,718,988 |
24.7% |
15 ( 6) |
Actos
| Takeda Pharmaceuticals North America, Inc |
1,605,016 |
15.6% |
16 ( 3) |
Zyprexa
| Eli Lilly and Company |
1,577,159 |
-16.2% |
17 ( 2) |
Fosamax
| Merck & Co., Inc. |
1,484,088 |
1.4% |
18 ( 2) |
Risperdal
| Janssen Pharmaceuticals, Inc |
1,472,597 |
2.5% |
19 ( 11) |
Avandia
| GlaxoSmithKline |
1,381,777 |
31.0% |
20 ( 6) |
Levaquin
| Janssen Pharmaceuticals, Inc |
1,348,110 |
19.4% |
21 ( 15) |
Wellbutrin XL
| Valeant Pharmaceuticals International |
1,326,323 |
39.8% |
22 ( 4) |
Pravachol
| Bristol-Myers Squibb Company |
1,315,013 |
-13.7% |
23 ( 5) |
Toprol XL
| AstraZeneca Pharmaceuticals |
1,294,098 |
20.3% |
24 ( 8) |
OxyContin
| Purdue Pharma LP |
1,285,922 |
-24.4% |
25 ( 7) |
Topamax
| Janssen Pharmaceuticals, Inc |
1,267,766 |
20.5% |
26 ( 17) |
Celebrex
| Pfizer Inc |
1,241,574 |
-41.3% |
27 ( 8) |
Enbrel
| Amgen Inc. |
1,130,642 |
18.4% |
28 ( 6) |
Lotrel
| Novartis Corporation |
1,109,867 |
14.3% |
29 ( 18) |
Abilify
| Bristol-Myers Squibb Company |
1,098,379 |
47.0% |
30 ( 1) |
Zithromax Z-Pak
| Pfizer Inc |
1,096,414 |
2.4% |
31 ( 2) |
Zyrtec
| Johnson & Johnson |
1,057,152 |
4.1% |
32 ( 7) |
Aciphex
| Eisai Corporation |
1,048,377 |
-8.0% |
33 ( 4) |
Flonase
| GlaxoSmithKline |
1,044,160 |
12.2% |
34 ( 9) |
Lamictal
| GlaxoSmithKline |
1,031,307 |
32.1% |
35 ( 10) |
Adderall XR
| Shire US Inc |
1,007,855 |
29.6% |
36 ( 6) |
Valtrex
| GlaxoSmithKline |
978,443 |
22.0% |
37 ( 14) |
Allegra
| Sanofi-Aventis |
957,152 |
-24.1% |
38 ( 39) |
Mobic
| Abbott Laboratories |
916,397 |
117.6% |
39 ( 11) |
Zetia
| Schering-Plough |
904,129 |
31.5% |
40 ( 6) |
Concerta
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
865,873 |
13.3% |
41 ( 15) |
Coreg
| GlaxoSmithKline |
846,802 |
35.2% |
42 ( 2) |
Imitrex Oral
| GlaxoSmithKline |
820,211 |
5.1% |
43 ( 5) |
Diovan
| Novartis Corporation |
810,581 |
12.0% |
44 ( 8) |
Actonel
| Procter & Gamble |
792,582 |
16.1% |
45 ( 6) |
Tricor
| Abbott Laboratories |
788,761 |
15.2% |
46 ( 17) |
Lantus
| Sanofi-Aventis |
774,711 |
44.2% |
47 ( 9) |
Viagra
| Pfizer Inc |
772,235 |
-14.8% |
48 ( 7) |
Diovan HCT
| Novartis Corporation |
723,998 |
15.3% |
49 ( ) |
Vytorin
| Merck & Co., Inc. |
715,174 |
>999 |
50 ( 3) |
Altace
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
700,630 |
6.2% |
51 ( 15) |
Crestor
| AstraZeneca Pharmaceuticals |
676,848 |
34.6% |
52 ( 7) |
Aricept
| Eisai Corporation |
651,887 |
11.6% |
53 ( 1) |
Strattera
| Eli Lilly and Company |
642,113 |
-0.6% |
54 ( 15) |
Synthroid
| Abbott Laboratories |
640,179 |
-26.7% |
55 ( 12) |
Nasonex
| Schering-Plough |
621,728 |
24.7% |
56 ( 7) |
Premarin Tabs
| Wyeth |
616,478 |
-12.3% |
| 57 |
Lamisil Oral
| Novartis Corporation |
608,718 |
0.9% |
58 ( 27) |
Omnicef
| Abbott Laboratories |
607,482 |
59.4% |
59 ( 3) |
Flomax
| Boehringer Ingelheim Pharmaceuticals, Inc |
583,267 |
7.7% |
| 60 |
Cozaar
| Merck & Co., Inc. |
580,627 |
4.0% |
61 ( ) |
Cymbalta
| Eli Lilly and Company |
570,421 |
926.7% |
62 ( 38) |
Duragesic
| |
569,671 |
-52.9% |
63 ( 5) |
Depakote
| Abbott Laboratories |
563,228 |
-4.4% |
64 ( 5) |
Zofran
| GlaxoSmithKline |
554,898 |
12.0% |
| 65 |
Detrol LA
| Pfizer Inc |
534,795 |
5.4% |
66 ( 5) |
Evista
| Eli Lilly and Company |
505,134 |
-7.3% |
67 ( 5) |
Combivent
| Boehringer Ingelheim Pharmaceuticals, Inc |
501,603 |
10.5% |
68 ( 20) |
Provigil
| Cephalon, Inc. |
496,944 |
42.5% |
69 ( 6) |
Pulmicort Respules
| AstraZeneca Pharmaceuticals |
486,297 |
12.9% |
70 ( 3) |
Humalog
| Eli Lilly and Company |
484,931 |
11.2% |
71 ( 29) |
Lidoderm
| Endo Pharmaceuticals |
470,692 |
50.0% |
72 ( 9) |
Cellcept
| Roche Pharmaceuticals |
461,825 |
15.6% |
73 ( 10) |
Trileptal
| Novartis Corporation |
458,425 |
14.9% |
74 ( 2) |
Hyzaar
| Merck & Co., Inc. |
448,157 |
4.9% |
75 ( 7) |
Skelaxin
| Elan Corporation |
445,377 |
11.5% |
76 ( 19) |
Yasmin 28
| Bayer Healthcare Pharmaceuticals |
441,299 |
34.7% |
77 ( 15) |
Lovenox
| Sanofi-Aventis |
438,815 |
32.7% |
78 ( 8) |
Prograf
| Astellas Pharma US |
431,631 |
19.2% |
79 ( 17) |
Depakote ER
| Abbott Laboratories |
428,334 |
17.9% |
80 ( 2) |
Ortho Evra
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
424,662 |
3.3% |
81 ( 9) |
Geodon Oral
| Pfizer Inc |
424,003 |
25.5% |
82 ( 2) |
Xalatan
| Pfizer Inc |
409,031 |
4.8% |
83 ( ) |
Allegra-D 12 Hour
| Sanofi-Aventis |
398,013 |
-1.4% |
84 ( 26) |
Humira
| Abbott Laboratories |
394,981 |
38.0% |
85 ( 6) |
Procrit
| Centocor Ortho Biotech, Inc |
393,527 |
-3.1% |
86 ( 12) |
Combivir
| GlaxoSmithKline |
392,859 |
-9.4% |
87 ( 24) |
Niaspan
| Abbott Laboratories |
380,690 |
33.2% |
88 ( 21) |
Keppra
| UCB Inc. |
379,564 |
31.4% |
89 ( 29) |
Actiq
| Abbott Laboratories |
370,704 |
41.3% |
90 ( 3) |
Zithromax
| Pfizer Inc |
358,460 |
8.6% |
91 ( 23) |
Clarinex
| Schering-Plough |
353,325 |
-27.8% |
92 ( 5) |
Avapro
| Bristol-Myers Squibb Company |
350,899 |
8.5% |
93 ( 32) |
Arimidex
| AstraZeneca Pharmaceuticals |
347,891 |
44.5% |
94 ( 13) |
Zithromax Susp
| |
342,532 |
18.3% |
95 ( 27) |
Ortho Tri-Cyclen Lo
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
339,177 |
37.2% |
96 ( 2) |
Asacol
| Procter & Gamble |
339,046 |
5.2% |
97 ( ) |
Spiriva
| Boehringer Ingelheim Pharmaceuticals, Inc |
337,827 |
231.9% |
98 ( 57) |
Paxil CR
| Apotex Corp |
332,100 |
-59.7% |
99 ( ) |
Truvada
| Gilead Sciences, Inc. |
326,641 |
>999 |
100 ( 21) |
Zelnorm
| Novartis Corporation |
318,220 |
26.4% |
101 ( 32) |
Reyataz
| Bristol-Myers Squibb Company |
313,778 |
37.6% |
| 102 |
Nasacort AQ
| Sanofi-Aventis |
311,467 |
0.6% |
103 ( 1) |
Sustiva
| Bristol-Myers Squibb Company |
309,140 |
4.2% |
104 ( 1) |
Rhinocort Aqua
| AstraZeneca Pharmaceuticals |
296,463 |
-3.6% |
105 ( 14) |
Ditropan XL
| Janssen Pharmaceuticals, Inc |
296,169 |
-11.6% |
106 ( 57) |
Cialis
| Eli Lilly and Company |
295,191 |
68.8% |
107 ( 21) |
Xopenex
| Sepracor Inc. (renamed Sunovion Pharmaceuticals Inc) |
293,131 |
21.9% |
108 ( 5) |
Avonex
| Biogen Idec |
292,545 |
4.2% |
109 ( ) |
Flovent HFA
| GlaxoSmithKline |
289,630 |
NA |
110 ( 5) |
Copaxone
| Sanofi-Aventis |
285,940 |
3.7% |
111 ( 3) |
Kaletra
| Abbott Laboratories |
284,892 |
-1.6% |
112 ( 58) |
Namenda
| Forest Pharmaceuticals, Inc |
283,270 |
74.9% |
113 ( 6) |
Patanol
| Alcon Laboratories, Inc. |
277,489 |
7.8% |
114 ( 27) |
Viread
| Gilead Sciences, Inc. |
271,732 |
-22.4% |
115 ( 23) |
Gleevec
| Novartis Corporation |
270,904 |
29.8% |
116 ( 18) |
Avalide
| Bristol-Myers Squibb Company |
268,019 |
19.1% |
117 ( ) |
Lunesta
| Sepracor Inc. (renamed Sunovion Pharmaceuticals Inc) |
264,331 |
>999 |
118 ( 51) |
Forteo
| Eli Lilly and Company |
263,801 |
61.7% |
119 ( 5) |
Amaryl
| Sanofi-Aventis |
262,732 |
-5.5% |
120 ( 26) |
Avandamet
| GlaxoSmithKline |
261,746 |
-20.7% |
121 ( 3) |
AndroGel
| Abbott Laboratories |
260,799 |
7.4% |
122 ( 7) |
Avelox
| Bayer Healthcare Pharmaceuticals |
259,386 |
10.2% |
123 ( 113) |
Neurontin
| Pfizer Inc |
255,121 |
-87.2% |
124 ( 1) |
Biaxin XL
| Abbott Laboratories |
255,017 |
4.1% |
125 ( 20) |
Trizivir
| GlaxoSmithKline |
253,825 |
-13.0% |
126 ( 32) |
Benicar
| Daiichi Sankyo |
251,486 |
41.4% |
127 ( 38) |
Elidel
| Novartis Corporation |
250,284 |
-28.0% |
128 ( 3) |
Proscar
| Merck & Co., Inc. |
238,949 |
2.5% |
129 ( 11) |
Budeprion SR
| Teva Pharmaceuticals |
234,441 |
14.9% |
130 ( 6) |
Norvir
| Abbott Laboratories |
231,111 |
9.0% |
131 ( ) |
Benicar HCT
| Daiichi Sankyo |
227,455 |
110.5% |
132 ( 5) |
Aldara
| Medicis Pharmaceutical Corporation |
226,878 |
8.0% |
133 ( 61) |
Fuzeon
| Roche Pharmaceuticals |
221,322 |
71.1% |
134 ( 32) |
Thalomid
| Celgene Corporation |
217,960 |
28.5% |
135 ( 8) |
Cefzil
| Bristol-Myers Squibb Company |
216,930 |
-9.8% |
136 ( 32) |
Zofran ODT
| GlaxoSmithKline |
214,014 |
29.8% |
137 ( 17) |
Coumadin Tabs
| Bristol-Myers Squibb Company |
209,652 |
-17.2% |
138 ( 3) |
Lescol XL
| Novartis Corporation |
208,515 |
-4.5% |
139 ( 9) |
Augmentin XR
| Dr. Reddy's Laboratories Inc. |
206,072 |
-11.9% |
140 ( 10) |
BenzaClin
| Sanofi-Aventis |
198,676 |
5.1% |
141 ( 10) |
Humalog Mix 75/25 Pn
| |
192,707 |
1.9% |
142 ( 36) |
Levoxyl
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
191,394 |
-34.3% |
143 ( 16) |
Cosopt
| Merck & Co., Inc. |
190,408 |
7.7% |
144 ( 1) |
Trinessa
| Watson Pharmaceuticals, Inc. |
186,951 |
-4.1% |
145 ( 6) |
Zyrtec Syrup
| |
186,643 |
-10.6% |
146 ( 15) |
RenaGel
| Genzyme Corporation |
185,001 |
5.3% |
147 ( 31) |
Prilosec
| AstraZeneca Pharmaceuticals |
183,953 |
-31.1% |
| 148 |
Alphagan P
| Allergan, Inc |
183,302 |
-3.4% |
149 ( 34) |
Tussionex
| Sanofi-Aventis |
181,586 |
29.6% |
150 ( 18) |
Endocet
| Endo Pharmaceuticals |
181,043 |
-21.7% |
151 ( 9) |
Miacalcin Nasal
| Novartis Corporation |
178,198 |
-11.7% |
152 ( 3) |
Inderal LA
| Wyeth |
177,720 |
-3.7% |
153 ( 4) |
Klor-Con
| Upsher-Smith Laboratories Inc. |
175,720 |
-7.2% |
154 ( ) |
Femara
| Novartis Corporation |
173,406 |
40.5% |
155 ( 27) |
Mirapex
| Boehringer Ingelheim Pharmaceuticals, Inc |
171,769 |
19.9% |
156 ( 16) |
Differin
| Galderma Laboratories |
168,877 |
4.5% |
157 ( 86) |
Flovent
| GlaxoSmithKline |
168,481 |
-63.1% |
158 ( 5) |
Humulin N
| Eli Lilly and Company |
168,427 |
-9.1% |
159 ( 17) |
Temodar
| Schering-Plough |
168,278 |
7.9% |
160 ( 48) |
Ortho Tri-Cyclen
| Janssen Pharmaceuticals, Inc |
168,080 |
-40.7% |
161 ( 20) |
Lumigan
| Allergan, Inc |
167,889 |
13.4% |
162 ( 3) |
Casodex
| AstraZeneca Pharmaceuticals |
167,447 |
-2.3% |
163 ( ) |
Arthrotec
| Pfizer Inc |
164,596 |
39.2% |
164 ( 18) |
Pegasys
| Genentech, Inc |
164,472 |
-14.2% |
165 ( 6) |
Zyrtec-D
| Pfizer Inc |
163,573 |
1.1% |
166 ( 6) |
Famvir
| GlaxoSmithKline |
163,368 |
-7.2% |
167 ( 10) |
Catapres-TTS
| Boehringer Ingelheim Pharmaceuticals, Inc |
163,076 |
5.8% |
168 ( ) |
Zyvox
| Pfizer Inc |
162,318 |
28.8% |
169 ( ) |
Relpax
| Pfizer Inc |
162,058 |
52.9% |
170 ( 14) |
Xeloda
| Genentech, Inc |
162,024 |
16.0% |
171 ( 17) |
DuoNeb
| Dey Pharma |
161,270 |
19.6% |
172 ( 16) |
Prozac
| Eli Lilly and Company |
158,240 |
-12.9% |
173 ( ) |
Tamiflu
| Genentech, Inc |
157,488 |
389.2% |
174 ( 4) |
Tobradex
| Alcon Laboratories, Inc. |
155,102 |
0.9% |
175 ( ) |
NovoLog Mix 70/30
| Novo Nordisk Inc. |
155,049 |
84.6% |
176 ( 22) |
Amnesteem
| Mylan Inc. |
153,534 |
-16.9% |
177 ( 78) |
Ultracet
| Janssen Pharmaceuticals, Inc |
152,802 |
-52.5% |
178 ( 5) |
Betaseron
| Bayer Healthcare Pharmaceuticals |
152,108 |
-4.6% |
179 ( 12) |
Arava
| Sanofi-Aventis |
151,574 |
-10.2% |
180 ( 11) |
Imitrex Inj
| |
149,914 |
12.1% |
181 ( ) |
Tarceva
| Genentech, Inc |
149,525 |
>999 |
182 ( 8) |
Neupogen
| Amgen Inc. |
148,760 |
-5.5% |
183 ( 4) |
Atacand
| AstraZeneca Pharmaceuticals |
148,636 |
-3.0% |
184 ( 153) |
Bextra
| Pfizer Inc |
148,370 |
-85.9% |
185 ( ) |
Ketek Pack
| |
148,321 |
256.5% |
186 ( ) |
Vigamox
| Alcon Laboratories, Inc. |
147,501 |
36.6% |
187 ( ) |
Aranesp
| Amgen Inc. |
147,016 |
53.9% |
188 ( ) |
Restasis
| Allergan, Inc |
146,559 |
67.9% |
189 ( 14) |
Zomig
| AstraZeneca Pharmaceuticals |
146,078 |
-7.1% |
190 ( ) |
Pulmozyme
| Genentech, Inc |
146,004 |
23.9% |
191 ( 47) |
Serevent Diskus
| GlaxoSmithKline |
144,773 |
-27.8% |
192 ( ) |
Astelin
| Meda Pharmaceuticals |
144,217 |
19.1% |
193 ( 13) |
Humulin 70/30
| Eli Lilly and Company |
142,436 |
-6.5% |
194 ( ) |
Levitra
| Bayer Healthcare Pharmaceuticals |
141,573 |
12.5% |
195 ( 3) |
Zonegran
| Eisai Corporation |
140,681 |
5.3% |
196 ( 34) |
DDAVP
| Sanofi-Aventis |
140,623 |
-19.9% |
197 ( ) |
Caduet
| Pfizer Inc |
139,305 |
480.3% |
198 ( 11) |
Prempro
| Pfizer Inc |
136,658 |
-0.9% |
199 ( 58) |
Epivir
| GlaxoSmithKline |
135,595 |
-33.1% |
200 ( ) |
Avinza
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
135,037 |
42.3% |
|
All Others |
|
23,609,356 |
-15.8% |