| Rank |
Drug |
Current Manufacturer |
Total Sales ($000) |
% Change 2003 |
| 1 |
Lipitor
| Pfizer Inc |
5,959,955 |
10.9% |
| 2 |
Prevacid
| Takeda Pharmaceuticals North America, Inc |
3,197,890 |
-4.8% |
| 3 |
Zocor
| Merck & Co., Inc. |
3,150,892 |
2.8% |
| 4 |
Nexium
| AstraZeneca Pharmaceuticals |
2,963,518 |
19.0% |
| 5 |
Zoloft
| Pfizer Inc |
2,622,801 |
6.6% |
| 6 |
Advair Diskus
| GlaxoSmithKline |
2,323,170 |
22.7% |
| 7 |
Effexor XR
| Wyeth |
2,281,014 |
19.4% |
| 8 |
Plavix
| Bristol-Myers Squibb Company |
2,169,479 |
30.4% |
| 9 |
Celebrex
| Pfizer Inc |
2,114,734 |
6.0% |
| 10 |
Neurontin
| Pfizer Inc |
2,000,077 |
3.1% |
| 11 |
Protonix
| Wyeth |
1,910,067 |
26.8% |
| 12 |
Norvasc
| Pfizer Inc |
1,883,014 |
9.8% |
| 13 |
Zyprexa
| Eli Lilly and Company |
1,881,354 |
-8.8% |
| 14 |
Singulair
| Merck & Co., Inc. |
1,849,025 |
24.2% |
| 15 |
Ambien
| Pfizer Inc |
1,719,253 |
18.3% |
| 16 |
OxyContin
| Purdue Pharma LP |
1,700,737 |
0.0% |
| 17 |
Lexapro
| Forest Pharmaceuticals, Inc |
1,551,230 |
69.2% |
| 18 |
Pravachol
| Bristol-Myers Squibb Company |
1,522,955 |
-3.7% |
| 19 |
Fosamax
| Merck & Co., Inc. |
1,463,390 |
6.8% |
| 20 |
Risperdal
| Janssen Pharmaceuticals, Inc |
1,436,891 |
1.9% |
| 21 |
Actos
| Takeda Pharmaceuticals North America, Inc |
1,388,002 |
12.5% |
| 22 |
Seroquel
| AstraZeneca Pharmaceuticals |
1,378,038 |
30.4% |
| 23 |
Allegra
| Sanofi-Aventis |
1,260,443 |
-6.6% |
| 24 |
Duragesic
| |
1,208,391 |
22.4% |
| 25 |
Aciphex
| Eisai Corporation |
1,139,155 |
8.8% |
| 26 |
Levaquin
| Janssen Pharmaceuticals, Inc |
1,128,679 |
8.0% |
| 27 |
Vioxx
| Merck & Co., Inc. |
1,088,453 |
-28.0% |
| 28 |
Toprol XL
| AstraZeneca Pharmaceuticals |
1,075,725 |
22.0% |
| 29 |
Zithromax Z-Pak
| Pfizer Inc |
1,070,535 |
-4.2% |
| 30 |
Avandia
| GlaxoSmithKline |
1,054,786 |
9.0% |
| 31 |
Bextra
| Pfizer Inc |
1,053,079 |
28.2% |
| 32 |
Topamax
| Janssen Pharmaceuticals, Inc |
1,052,107 |
24.0% |
| 33 |
Zyrtec
| Johnson & Johnson |
1,015,113 |
-2.1% |
| 34 |
Lotrel
| Novartis Corporation |
970,827 |
20.4% |
| 35 |
Enbrel
| Amgen Inc. |
955,266 |
22.5% |
| 36 |
Wellbutrin XL
| Valeant Pharmaceuticals International |
948,683 |
915.9% |
| 37 |
Flonase
| GlaxoSmithKline |
930,267 |
11.3% |
| 38 |
Viagra
| Pfizer Inc |
906,580 |
-19.2% |
| 39 |
Synthroid
| Abbott Laboratories |
873,282 |
-1.1% |
| 40 |
Celexa
| Forest Pharmaceuticals, Inc |
856,665 |
-29.5% |
| 41 |
Paxil CR
| Apotex Corp |
824,433 |
15.4% |
| 42 |
Valtrex
| GlaxoSmithKline |
801,721 |
31.8% |
| 43 |
Lamictal
| GlaxoSmithKline |
780,614 |
44.0% |
| 44 |
Imitrex Oral
| GlaxoSmithKline |
780,613 |
1.9% |
| 45 |
Adderall XR
| Shire US Inc |
777,879 |
38.1% |
| 46 |
Concerta
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
764,317 |
24.3% |
| 47 |
Abilify
| Bristol-Myers Squibb Company |
747,400 |
115.1% |
| 48 |
Diovan
| Novartis Corporation |
723,821 |
21.2% |
| 49 |
Premarin Tabs
| Wyeth |
702,872 |
-18.0% |
| 50 |
Zetia
| Schering-Plough |
687,673 |
104.8% |
| 51 |
Tricor
| Abbott Laboratories |
684,984 |
28.8% |
| 52 |
Actonel
| Procter & Gamble |
682,554 |
47.1% |
| 53 |
Altace
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
659,710 |
11.5% |
| 54 |
Strattera
| Eli Lilly and Company |
646,238 |
87.3% |
| 55 |
Diovan HCT
| Novartis Corporation |
627,878 |
29.8% |
| 56 |
Coreg
| GlaxoSmithKline |
626,189 |
36.4% |
| 57 |
Lamisil Oral
| Novartis Corporation |
603,003 |
11.6% |
| 58 |
Depakote
| Abbott Laboratories |
588,935 |
-1.6% |
| 59 |
Aricept
| Eisai Corporation |
584,302 |
18.5% |
| 60 |
Cozaar
| Merck & Co., Inc. |
558,232 |
7.8% |
| 61 |
Evista
| Eli Lilly and Company |
544,966 |
-1.2% |
| 62 |
Flomax
| Boehringer Ingelheim Pharmaceuticals, Inc |
541,800 |
4.9% |
| 63 |
Lantus
| Sanofi-Aventis |
537,299 |
54.2% |
| 64 |
Wellbutrin SR
| GlaxoSmithKline |
529,332 |
-66.8% |
| 65 |
Detrol LA
| Pfizer Inc |
507,354 |
14.8% |
| 66 |
Crestor
| AstraZeneca Pharmaceuticals |
503,011 |
>999 |
| 67 |
Nasonex
| Schering-Plough |
498,730 |
1.5% |
| 68 |
Clarinex
| Schering-Plough |
498,199 |
-18.9% |
| 69 |
Zofran
| GlaxoSmithKline |
495,657 |
15.9% |
| 70 |
Accupril
| Pfizer Inc |
457,876 |
-10.7% |
| 71 |
Flovent
| GlaxoSmithKline |
456,600 |
-8.8% |
| 72 |
Combivent
| Boehringer Ingelheim Pharmaceuticals, Inc |
454,028 |
15.5% |
| 73 |
Humalog
| Eli Lilly and Company |
435,911 |
4.0% |
| 74 |
Combivir
| GlaxoSmithKline |
433,516 |
5.3% |
| 75 |
Pulmicort Respules
| AstraZeneca Pharmaceuticals |
430,807 |
21.5% |
| 76 |
Hyzaar
| Merck & Co., Inc. |
427,072 |
11.4% |
| 77 |
Mobic
| Abbott Laboratories |
421,165 |
60.4% |
| 78 |
Ortho Evra
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
411,189 |
23.2% |
| 79 |
Procrit
| Centocor Ortho Biotech, Inc |
406,212 |
-3.2% |
| 80 |
Allegra-D
| |
403,507 |
-8.1% |
| 81 |
Cellcept
| Roche Pharmaceuticals |
399,650 |
15.5% |
| 82 |
Skelaxin
| Elan Corporation |
399,381 |
8.6% |
| 83 |
Trileptal
| Novartis Corporation |
399,001 |
27.7% |
| 84 |
Xalatan
| Pfizer Inc |
390,196 |
7.5% |
| 85 |
Omnicef
| Abbott Laboratories |
381,124 |
26.8% |
| 86 |
Prograf
| Astellas Pharma US |
362,051 |
20.5% |
| 87 |
Viread
| Gilead Sciences, Inc. |
350,319 |
34.5% |
| 88 |
Provigil
| Cephalon, Inc. |
348,785 |
36.4% |
| 89 |
Elidel
| Novartis Corporation |
347,733 |
43.8% |
| 90 |
Geodon Oral
| Pfizer Inc |
337,826 |
35.2% |
| 91 |
Ditropan XL
| Janssen Pharmaceuticals, Inc |
335,038 |
2.3% |
| 92 |
Lovenox
| Sanofi-Aventis |
330,773 |
8.8% |
| 93 |
Zithromax
| Pfizer Inc |
330,200 |
28.6% |
| 94 |
Avandamet
| GlaxoSmithKline |
330,146 |
192.8% |
| 95 |
Yasmin 28
| Bayer Healthcare Pharmaceuticals |
327,574 |
51.8% |
| 96 |
Depakote ER
| Abbott Laboratories |
326,183 |
35.1% |
| 97 |
Avapro
| Bristol-Myers Squibb Company |
323,367 |
12.3% |
| 98 |
Asacol
| Procter & Gamble |
322,219 |
7.4% |
| 99 |
Ultracet
| Janssen Pharmaceuticals, Inc |
321,984 |
16.4% |
| 100 |
Lidoderm
| Endo Pharmaceuticals |
313,786 |
69.0% |
| 101 |
Diflucan
| Pfizer Inc |
312,619 |
-27.9% |
| 102 |
Nasacort AQ
| Sanofi-Aventis |
309,590 |
9.5% |
| 103 |
Rhinocort Aqua
| AstraZeneca Pharmaceuticals |
307,406 |
6.0% |
| 104 |
Sustiva
| Bristol-Myers Squibb Company |
296,783 |
15.5% |
| 105 |
Trizivir
| GlaxoSmithKline |
291,605 |
-1.2% |
| 106 |
Levoxyl
| King Pharmaceuticals, Inc. (now part of Pfizer - October 2010) |
291,498 |
-17.3% |
| 107 |
Zithromax Susp
| |
289,444 |
-6.9% |
| 108 |
Kaletra
| Abbott Laboratories |
289,392 |
3.9% |
| 109 |
Keppra
| UCB Inc. |
288,777 |
42.1% |
| 110 |
Humira
| Abbott Laboratories |
286,283 |
109.6% |
| 111 |
Niaspan
| Abbott Laboratories |
285,880 |
49.6% |
| 112 |
Ortho Tri-Cyclen
| Janssen Pharmaceuticals, Inc |
283,274 |
-62.6% |
| 113 |
Avonex
| Biogen Idec |
280,874 |
-0.1% |
| 114 |
Amaryl
| Sanofi-Aventis |
278,094 |
18.2% |
| 115 |
Copaxone
| Sanofi-Aventis |
275,838 |
-0.6% |
| 116 |
Prilosec
| AstraZeneca Pharmaceuticals |
266,809 |
-64.3% |
| 117 |
Metformin HCl ER
| |
265,898 |
>999 |
| 118 |
Actiq
| Abbott Laboratories |
262,320 |
32.4% |
| 119 |
Patanol
| Alcon Laboratories, Inc. |
257,327 |
4.8% |
| 120 |
Coumadin Tabs
| Bristol-Myers Squibb Company |
253,341 |
-10.2% |
| 121 |
Zelnorm
| Novartis Corporation |
251,846 |
89.4% |
| 122 |
Ortho Tri-Cyclen Lo
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
247,173 |
160.8% |
| 123 |
Biaxin XL
| Abbott Laboratories |
244,968 |
-16.2% |
| 124 |
AndroGel
| Abbott Laboratories |
242,917 |
10.7% |
| 125 |
Arimidex
| AstraZeneca Pharmaceuticals |
240,802 |
48.4% |
| 126 |
Glucovance
| Bristol-Myers Squibb Company |
240,686 |
-44.5% |
| 127 |
Cefzil
| Bristol-Myers Squibb Company |
240,520 |
-22.8% |
| 128 |
Xopenex
| Sepracor Inc. (renamed Sunovion Pharmaceuticals Inc) |
240,430 |
14.9% |
| 129 |
Avelox
| Bayer Healthcare Pharmaceuticals |
235,322 |
4.6% |
| 130 |
Augmentin XR
| Dr. Reddy's Laboratories Inc. |
233,839 |
14.0% |
| 131 |
Proscar
| Merck & Co., Inc. |
233,194 |
8.2% |
| 132 |
Endocet
| Endo Pharmaceuticals |
231,148 |
90.8% |
| 133 |
Reyataz
| Bristol-Myers Squibb Company |
228,081 |
357.3% |
| 134 |
Avalide
| Bristol-Myers Squibb Company |
225,070 |
32.9% |
| 135 |
Lescol XL
| Novartis Corporation |
218,382 |
10.7% |
| 136 |
Norvir
| Abbott Laboratories |
211,971 |
440.6% |
| 137 |
Aldara
| Medicis Pharmaceutical Corporation |
210,160 |
23.3% |
| 138 |
Gleevec
| Novartis Corporation |
208,952 |
34.2% |
| 139 |
Zyrtec Syrup
| |
208,884 |
-1.7% |
| 140 |
Budeprion SR
| Teva Pharmaceuticals |
203,954 |
NA |
| 141 |
Epivir
| GlaxoSmithKline |
202,566 |
-1.1% |
| 142 |
Miacalcin Nasal
| Novartis Corporation |
201,855 |
0.1% |
| 143 |
Augmentin ES-600
| Dr. Reddy's Laboratories Inc. |
201,822 |
-23.3% |
| 144 |
Serevent Diskus
| GlaxoSmithKline |
200,636 |
48.7% |
| 145 |
Trinessa
| Watson Pharmaceuticals, Inc. |
195,038 |
>999 |
| 146 |
Pegasys
| Genentech, Inc |
191,754 |
41.3% |
| 147 |
Accutane
| Roche Pharmaceuticals |
191,441 |
-29.7% |
| 148 |
Alphagan P
| Allergan, Inc |
189,749 |
-4.0% |
| 149 |
Klor-Con
| Upsher-Smith Laboratories Inc. |
189,304 |
-5.5% |
| 150 |
BenzaClin
| Sanofi-Aventis |
189,081 |
6.8% |
| 151 |
Humalog Mix 75/25 Pn
| |
189,024 |
-11.6% |
| 152 |
Biaxin
| Abbott Laboratories |
187,485 |
-15.4% |
| 153 |
Humulin N
| Eli Lilly and Company |
185,325 |
-17.8% |
| 154 |
Amnesteem
| Mylan Inc. |
184,826 |
-3.6% |
| 155 |
Inderal LA
| Wyeth |
184,484 |
-1.2% |
| 156 |
Prozac
| Eli Lilly and Company |
181,717 |
-18.2% |
| 157 |
Cipro
| Bayer Healthcare Pharmaceuticals |
181,254 |
-73.1% |
| 158 |
Benicar
| Daiichi Sankyo |
177,847 |
91.6% |
| 159 |
Cosopt
| Merck & Co., Inc. |
176,797 |
10.5% |
| 160 |
Famvir
| GlaxoSmithKline |
175,962 |
3.2% |
| 161 |
RenaGel
| Genzyme Corporation |
175,737 |
19.9% |
| 162 |
DDAVP
| Sanofi-Aventis |
175,548 |
9.4% |
| 163 |
Cialis
| Eli Lilly and Company |
174,849 |
>999 |
| 164 |
Paxil
| Apotex Corp |
171,499 |
-87.3% |
| 165 |
Casodex
| AstraZeneca Pharmaceuticals |
171,366 |
3.9% |
| 166 |
Thalomid
| Celgene Corporation |
169,566 |
31.7% |
| 167 |
Arava
| Sanofi-Aventis |
168,839 |
14.0% |
| 168 |
Zofran ODT
| GlaxoSmithKline |
164,910 |
61.9% |
| 169 |
Forteo
| Eli Lilly and Company |
163,148 |
214.5% |
| 170 |
Namenda
| Forest Pharmaceuticals, Inc |
161,930 |
>999 |
| 171 |
Zyrtec-D
| Pfizer Inc |
161,758 |
2.3% |
| 172 |
Differin
| Galderma Laboratories |
161,587 |
3.9% |
| 173 |
Betaseron
| Bayer Healthcare Pharmaceuticals |
159,381 |
2.1% |
| 174 |
Neupogen
| Amgen Inc. |
157,428 |
-16.1% |
| 175 |
Zomig
| AstraZeneca Pharmaceuticals |
157,216 |
-9.2% |
| 176 |
Temodar
| Schering-Plough |
155,938 |
19.6% |
| 177 |
Catapres-TTS
| Boehringer Ingelheim Pharmaceuticals, Inc |
154,143 |
7.8% |
| 178 |
Tobradex
| Alcon Laboratories, Inc. |
153,757 |
-4.2% |
| 179 |
Atacand
| AstraZeneca Pharmaceuticals |
153,224 |
-2.1% |
| 180 |
Humulin 70/30
| Eli Lilly and Company |
152,321 |
-15.2% |
| 181 |
Lumigan
| Allergan, Inc |
148,024 |
18.8% |
| 182 |
Mirapex
| Boehringer Ingelheim Pharmaceuticals, Inc |
143,300 |
11.6% |
| 183 |
Tussionex
| Sanofi-Aventis |
140,072 |
-5.3% |
| 184 |
Xeloda
| Genentech, Inc |
139,676 |
8.2% |
| 185 |
Reminyl
| Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
138,931 |
17.7% |
| 186 |
Exelon
| Novartis Corporation |
138,094 |
-4.5% |
| 187 |
Prempro
| Pfizer Inc |
137,847 |
-37.3% |
| 188 |
DuoNeb
| Dey Pharma |
134,801 |
51.3% |
| 189 |
Rebif
| |
134,198 |
23.2% |
| 190 |
Dovonex
| Bristol-Myers Squibb Company |
134,137 |
-1.6% |
| 191 |
Imitrex Inj
| |
133,684 |
-20.8% |
| 192 |
Zonegran
| Eisai Corporation |
133,600 |
39.5% |
| 193 |
Pletal
| Pfizer Inc |
132,987 |
-0.4% |
| 194 |
Fuzeon
| Roche Pharmaceuticals |
129,369 |
416.3% |
| 195 |
Plendil
| AstraZeneca Pharmaceuticals |
129,306 |
-15.4% |
| 196 |
Iressa
| AstraZeneca Pharmaceuticals |
128,419 |
146.4% |
| 197 |
Aviane
| |
127,726 |
3.9% |
| 198 |
Viramune
| Boehringer Ingelheim Pharmaceuticals, Inc |
127,683 |
5.3% |
| 199 |
Tequin
| Bristol-Myers Squibb Company |
127,612 |
-19.2% |
| 200 |
Zerit
| Bristol-Myers Squibb Company |
126,427 |
-22.1% |
|
All Others |
|
24,121,195 |
-6.8% |