Zytiga Side Effects
Generic name: abiraterone
Note: This document contains side effect information about abiraterone. Some of the dosage forms listed on this page may not apply to the brand name Zytiga.
Some side effects of Zytiga may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to abiraterone: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking abiraterone (the active ingredient contained in Zytiga) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using abiraterone and call your doctor at once if you have:
swelling in your ankles or feet, pain in your legs;
rapid heartbeats, feeling short of breath (even with mild exertion);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
pale skin, easy bruising, feeling like you might pass out;
upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
pain or burning when you urinate;
high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
worsening dizziness, weakness, or tired feeling;
nausea, vomiting, ongoing diarrhea; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Common side effects may include:
swelling or discomfort in your joints;
sweating, feeling very hot.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to abiraterone: oral tablet
In general, the most commonly reported side effects have included joint swelling or discomfort, hypokalemia, edema, muscle discomfort, hot flushes, diarrhea, urinary tract infection, cough, hypertension, arrhythmia, urinary frequency, nocturia, dyspepsia, and upper respiratory tract infection. The most common adverse effects which resulted in discontinuation of abiraterone (the active ingredient contained in Zytiga) have included increased transaminases (ALT, AST), urosepsis, and heart failure.
Cardiovascular side effects have included hypertension, edema, hot flushes, arrhythmias, atrial and ventricular tachycardia, supraventricular tachycardia, atrial flutter, bradycardia, AV block, chest pain or discomfort, angina, left ventricular dysfunction, cardiogenic shock, cardiomegaly, cardiomyopathy, decreased ejection fraction, and heart failure.
Endocrine side effects have included adrenocortical insufficiency.
Gastrointestinal side effects have included diarrhea and dyspepsia.
Genitourinary side effects have included urinary tract infection, urinary frequency, nocturia, and urosepsis.
Hepatic side effects have included hepatotoxicity, increased AST, increased ALT, and increased bilirubin
Metabolic side effects have included hypokalemia, fluid retention, and low serum phosphate.
Musculoskeletal side effects have included joint swelling or discomfort, muscle discomfort, arthritis, arthralgia, muscle spasms, musculoskeletal pain or discomfort, myalgia and fractures.
Respiratory side effects have included cough and upper respiratory tract infection.
More Zytiga resources
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