Zytiga Side Effects
Generic Name: abiraterone
Note: This document contains side effect information about abiraterone. Some of the dosage forms listed on this page may not apply to the brand name Zytiga.
Some side effects of Zytiga may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to abiraterone: oral tablet
Along with its needed effects, abiraterone (the active ingredient contained in Zytiga) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abiraterone:More common
- Bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or cloudy urine
- blurred vision
- bone fracture
- chest pain or discomfort
- decreased urine
- difficult, burning, or painful urination
- dry mouth
- fast, pounding, or irregular heartbeat or pulse
- feeling of warmth
- frequent urge to urinate
- increased need to urinate
- increased thirst
- increased urge to urinate during the night
- lightheadedness, dizziness, or fainting
- loss of appetite
- lower back or side pain
- mood changes
- muscle pain or cramps
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- pain or swelling in the arms or legs without any injury
- passing urine more often
- pounding in the ears
- rapid weight gain
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- slow heartbeat
- sudden sweating
- swelling with pits or depressions on the skin
- unusual tiredness or weakness
- unusual weight gain or loss
- waking to urinate at night
- Abdominal or stomach pain or tenderness
- arm, back, or jaw pain
- chest tightness or heaviness
- clay colored stools
- cool, sweaty skin
- dark urine
- decreased appetite
- decreased urine output
- difficulty with breathing
- dilated neck veins
- extreme fatigue
- irregular breathing
- itching skin
- swelling of the face, fingers, feet, or lower legs
- weight gain
- yellow eyes or skin
- Darkening of the skin
- mental depression
Some side effects of abiraterone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Acid or sour stomach
- body aches or pain
- difficulty with moving
- ear congestion
- joint pain
- loss of voice
- muscle cramps or spasms
- muscle or bone pain
- muscle stiffness
- nasal congestion
- runny nose
- sore throat
- stomach discomfort or upset
- swelling or stiffness of the joints
For Healthcare Professionals
Applies to abiraterone: oral tablet
In general, the most commonly reported side effects have included joint swelling or discomfort, hypokalemia, edema, muscle discomfort, hot flushes, diarrhea, urinary tract infection, cough, hypertension, arrhythmia, urinary frequency, nocturia, dyspepsia, and upper respiratory tract infection. The most common adverse effects which resulted in discontinuation of abiraterone (the active ingredient contained in Zytiga) have included increased transaminases (ALT, AST), urosepsis, and heart failure.
Cardiovascular side effects have included hypertension, edema, hot flushes, arrhythmias, atrial and ventricular tachycardia, supraventricular tachycardia, atrial flutter, bradycardia, AV block, chest pain or discomfort, angina, left ventricular dysfunction, cardiogenic shock, cardiomegaly, cardiomyopathy, decreased ejection fraction, and heart failure.
Endocrine side effects have included adrenocortical insufficiency.
Gastrointestinal side effects have included diarrhea and dyspepsia.
Genitourinary side effects have included urinary tract infection, urinary frequency, nocturia, and urosepsis.
Hepatic side effects have included hepatotoxicity, increased AST, increased ALT, and increased bilirubin
Metabolic side effects have included hypokalemia, fluid retention, and low serum phosphate.
Musculoskeletal side effects have included joint swelling or discomfort, muscle discomfort, arthritis, arthralgia, muscle spasms, musculoskeletal pain or discomfort, myalgia and fractures.
Respiratory side effects have included cough and upper respiratory tract infection.
More about Zytiga (abiraterone)
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