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Unoprostone ophthalmic Side Effects

It is possible that some side effects of unoprostone ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to unoprostone ophthalmic: ophthalmic solution

As well as its needed effects, unoprostone ophthalmic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking unoprostone ophthalmic, check with your doctor or nurse as soon as possible:

Less common
  • Blood in the whites of the eyes
  • blurred vision or eye pain
  • eye irritation or redness
Rare
  • Blindness
  • color blindness
  • decreased vision or other changes in vision

Some unoprostone ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abnormal tearing of eyes
  • burning or stinging of eyes
  • chills
  • cough
  • diarrhea
  • double vision
  • dry eyes
  • fever
  • general feeling of discomfort or illness
  • headache
  • itching of eyes
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Less common or rare
  • Discharge from eye
  • inflammation of the eye
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • sensitivity to light

Some unoprostone ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Feeling of having something in the eye
  • increased or decreased length of eyelashes
Less common or rare
  • Change in the color of the iris or eyelid
  • increase in number of eyelashes
  • difficulty seeing at night
  • increased sensitivity of eyes to sunlight

For Healthcare Professionals

Applies to unoprostone ophthalmic: ophthalmic solution

Ocular

Unoprostone ophthalmic may change the eye color. This is caused by a gradual increase of the brown pigment in the iris. The change in iris color is slow and may not be noticeable for months.

When administered to animals for 12 months, one of ten animals exhibited increased pigmentation of the iris.

The manufacturer reports after 12 months of therapy an increased length in eyelashes (>= 1 mm) in approximately 10% to 14% of patients and a decreased length in eyelashes in 7% of patients.

Ocular side effects have included burning and stinging, burning and stinging upon drug instillation, dry eyes, itching of eyes, increased or decreased length of eyelashes, and injection in 10% to 25% of patients. Abnormal vision, eyelid disorder, foreign body sensation, and lacrimation disorder have been reported in 5% to 10% of patients. Blepharitis, cataract, conjunctivitis, corneal lesion, discharge from the eye, eye hemorrhage, eye pain, keratitis, irritation, photophobia, and vitreous disorder have been reported rarely. Acute elevated intraocular pressure, color blindness, corneal deposits, corneal edema, corneal opacity, cystoid macular edema, diplopia, hyperpigmentation of the eyelid, increased number of eyelashes, iris hyperpigmentation, iritis, macular edema, optic atrophy, retinal hemorrhage, and visual field disturbance have also been reported.

Respiratory

Respiratory side effects have included increased cough, pharyngitis, rhinitis, sinusitis, and bronchitis in 1% to 5% of patients.

Nervous system

Nervous system side effects have included headache, dizziness and insomnia in 1% to 5% of patients.

Musculoskeletal

Musculoskeletal side effects have included back pain (1% to 5%).

Metabolic

Metabolic side effects have included diabetes mellitus (1% to 5%).

Cardiovascular

Cardiovascular side effects have included hypertension (1% to 5%).

Gastrointestinal

Gastrointestinal side effects have included nausea.

Other

Other side effects have included flu syndrome (6%), accidental injury (1% to 5%), and pain (1% to 5%).

Hypersensitivity

Hypersensitivity side effects have included allergic reaction (1% to 5%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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