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Unoprostone ophthalmic Pregnancy and Breastfeeding Warnings

Unoprostone ophthalmic is also known as: Rescula

Unoprostone ophthalmic Pregnancy Warnings

Unoprostone ophthalmic has been assigned to pregnancy category C by the FDA. Animal studies have revealed increased evidence of miscarriages, a decreased number of live fetuses, and an increase in the number of stillborns following large subcutaneous doses. There are no controlled data in human pregnancy. Unoprostone undergoes minimal systemic absorption after ocular administration (<1.5 ng/mL). Unoprostone ophthalmic is only recommended for use during pregnancy when benefit outweighs risk.

Unoprostone ophthalmic Breastfeeding Warnings

There are no data on the excretion of topically administered unoprostone ophthalmic into human milk. It is excreted in rat milk after intravenous administration. Unoprostone undergoes minimal systemic absorption after ocular administration (<1.5 ng/mL). The manufacturer recommends caution when administering unoprostone ophthalmic to nursing women.

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