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Typhoid vaccine, inactivated Side Effects

It is possible that some side effects of typhoid vaccine, inactivated may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to typhoid vaccine, inactivated: intramuscular injectable, intramuscular solution

As well as its needed effects, a vaccine may cause unwanted side effects that require medical attention. It is very important that you tell your doctor about any side effects that occur after a dose of typhoid vaccine, even though the side effect may have gone away without treatment. Some types of side effects may mean that you should not receive any more doses of typhoid vaccine.

If any of the following side effects occur while taking typhoid vaccine, inactivated, check with your doctor immediately:

  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some typhoid vaccine, inactivated side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Fever
  • general feeling of discomfort or illness
  • headache
  • muscle pain
  • pain, redness, or swelling at place of injection

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule


Local side effects have included tenderness, pain, induration, and erythema at the injection site.[Ref]


Hypersensitivity reactions have included urticaria. A patient with a history of multiple allergies developed sweats, myalgia, and difficulty breathing 2 hours after vaccination. She had previously received 2 series of whole-cell typhoid vaccine.[Ref]


Gastrointestinal side effects have included nausea, diarrhea, and vomiting.[Ref]


Other side effects have included malaise, headache, fever, flu-like symptoms, and abdominal pain.[Ref]


Cardiovascular side effects have included hypotension.[Ref]


Hematologic side effects have included one report of neutropenia 2 days after vaccination in a female who had concurrently received yellow fever vaccine.[Ref]


Musculoskeletal side effects have included myalgia and cervical pain. Diffuse arthralgias and fever were reported in a female 2 weeks after vaccination who had concurrently received hepatitis B vaccine. Polyarthritis was reported in a male 4 days after vaccination who had concurrently received meningococcal and DTP vaccines.[Ref]

Nervous system

Nervous system side effects reported during postmarketing surveillance have included loss of consciousness and tremors.[Ref]


Ocular side effects have included one report of bilateral retinitis 3 weeks after vaccination in a male who had concurrently received hepatitis B vaccine.[Ref]


Renal side effects have included one report of glomerulonephritis 7 days after vaccination in a male who had also received BCG vaccine.[Ref]


1. "Product Information. Typhim Vi (typhoid vaccine)." Connaught, Swiftwater, PA.

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