Typhoid vaccine, inactivated Side Effects

Some side effects of typhoid vaccine, inactivated may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to typhoid vaccine, inactivated: intramuscular injectable, intramuscular solution

Along with its needed effects, a vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It is very important that you tell your doctor about any side effects that occur after a dose of typhoid vaccine, even though the side effect may have gone away without treatment. Some types of side effects may mean that you should not receive any more doses of typhoid vaccine.

Check with your doctor immediately if any of the following side effects occur while taking typhoid vaccine, inactivated:

  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects of typhoid vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Fever
  • general feeling of discomfort or illness
  • headache
  • muscle pain
  • pain, redness, or swelling at place of injection

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule


Local side effects have included tenderness, pain, induration, and erythema at the injection site.


Hypersensitivity reactions have included urticaria. A patient with a history of multiple allergies developed sweats, myalgia, and difficulty breathing 2 hours after vaccination. She had previously received 2 series of whole-cell typhoid vaccine.


Gastrointestinal side effects have included nausea, diarrhea, and vomiting.


Other side effects have included malaise, headache, fever, flu-like symptoms, and abdominal pain.


Cardiovascular side effects have included hypotension.


Hematologic side effects have included one report of neutropenia 2 days after vaccination in a female who had concurrently received yellow fever vaccine.


Musculoskeletal side effects have included myalgia and cervical pain. Diffuse arthralgias and fever were reported in a female 2 weeks after vaccination who had concurrently received hepatitis B vaccine. Polyarthritis was reported in a male 4 days after vaccination who had concurrently received meningococcal and DTP vaccines.

Nervous system

Nervous system side effects reported during postmarketing surveillance have included loss of consciousness and tremors.


Ocular side effects have included one report of bilateral retinitis 3 weeks after vaccination in a male who had concurrently received hepatitis B vaccine.


Renal side effects have included one report of glomerulonephritis 7 days after vaccination in a male who had also received BCG vaccine.

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