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Typhoid vaccine, inactivated Side Effects

It is possible that some side effects of typhoid vaccine, inactivated may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to typhoid vaccine, inactivated: intramuscular injectable, intramuscular solution

As well as its needed effects, a vaccine may cause unwanted side effects that require medical attention. It is very important that you tell your doctor about any side effects that occur after a dose of typhoid vaccine, even though the side effect may have gone away without treatment. Some types of side effects may mean that you should not receive any more doses of typhoid vaccine.

If any of the following side effects occur while taking typhoid vaccine, inactivated, check with your doctor immediately:

  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some typhoid vaccine, inactivated side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Fever
  • general feeling of discomfort or illness
  • headache
  • muscle pain
  • pain, redness, or swelling at place of injection

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule


The most common adverse events were injection site reactions.[Ref]


Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)
Common (1% to 10%): Swelling
Very rare (less than 0.01%): Edema[Ref]

Local reactions usually resolved within 48 hours of vaccination.[Ref]


Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)
Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches
Postmarketing reports: Asthenia, flu-like episode[Ref]

Nervous system

Very common (10% or more): Headache (27%)
Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection[Ref]


Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting
Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Itching
Very rare (less than 0.01%): Urticaria, rash[Ref]


Common (1% to 10%): Myalgia
Postmarketing reports: Arthralgia, cervical pain, polyarthritis[Ref]


Postmarketing reports: Lymphadenopathy, neutropenia[Ref]


Postmarketing reports: Bilateral retinitis[Ref]


Postmarketing reports: Glomerulonephritis[Ref]


Postmarketing reports: Asthma[Ref]


1. "Product Information. Typhim Vi (typhoid vaccine)." Connaught, Swiftwater, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

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