Typhoid Vaccine, Inactivated Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Typhoid Prophylaxis

0.5 mL IM once in the deltoid.

The vaccine should be given at least 2 weeks before potential exposure to S typhi.

Booster: 0.5 mL IM every 2 years if there is continued exposure to Salmonella typhi.

Usual Pediatric Dose for Typhoid Prophylaxis

>2 years:
0.5 mL IM once in the deltoid or the vastus lateralis. Do not inject into the gluteal area where there may be a nerve trunk.

The vaccine should be given at least 2 weeks before potential exposure to S typhi.

Booster: 0.5 mL IM every 2 years if there is continued exposure to Salmonella typhi.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

For IM use only. Special care should be taken to ensure that typhoid vaccine is not injected into a blood vessel.

The expected immune response may not occur in immunosuppressed patients.

Caution is recommended in patients with thrombocytopenia or coagulation disorders that would contraindicate intramuscular injection.

Delaying vaccination should be considered if the patients has an acute infection or febrile illness.

There are no safety and immunogenicity data for individuals who have been previously vaccinated with live oral typhoid or whole-cell typhoid vaccines.

Vaccinees should be advised to take personal precautions to avoid typhoid exposure (i.e., avoiding contact with or ingestion of contaminated food and water) because typhoid vaccines do not completely protect all recipients and may be overwhelmed by large inocula.

Dialysis

No adjustment recommended

Other Comments

The vaccine must be refrigerated to maintain full potency. Do not freeze.

Adverse reactions should be reported to the U.S. Department of Health and Human Services Vaccine Adverse Event Reporting System. Reporting forms and information regarding the completion of the form can be obtained at 1-800-822-7967 (USA).

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