Ticar Side Effects

Generic Name: ticarcillin disodium and clavulanate potassium

Please note - some side effects for Ticar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Ticar - for the Consumer

Ticarcillin/Clavulanate

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ticarcillin/Clavulanate:

Changes in taste and smell; diarrhea; gas; giddiness; headache; nausea; pain, swelling, or redness at the injection site; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Ticarcillin/Clavulanate:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; dark or bloody urine; fever, chills, or sore throat; joint or muscle pain; persistent painful urination; red, swollen, or blistered skin; seizures; severe diarrhea; severe stomach pain/cramps; swelling in the mouth; unusual bruising or bleeding; vaginal irritation or discharge; vein swelling or tenderness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Ticarcillin

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ticarcillin:

Changes in taste and smell; diarrhea; gas; giddiness; headache; nausea; pain, swelling, or redness at the injection site; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Ticarcillin:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; dark urine; fever, chills, or sore throat; joint or muscle pain; red, swollen, or blistered skin; seizures; severe diarrhea; severe stomach pain/cramps; swelling in the mouth; unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge; vein swelling or tenderness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

Ticar

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ticar:

Changes in taste and smell; diarrhea; gas; giddiness; headache; nausea; pain, swelling, or redness at the injection site; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Ticar:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; dark urine; fever, chills, or sore throat; joint or muscle pain; red, swollen, or blistered skin; seizures; severe diarrhea; severe stomach pain/cramps; swelling in the mouth; unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge; vein swelling or tenderness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

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Ticar Side Effects - for the Professional

Ticar

The following adverse reactions may occur:

Hypersensitivity Reactions: Skin rashes, pruritus, urTicaria, drug fever.

Gastrointestinal Disturbances: Nausea and vomiting, pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.

Hemic and Lymphatic Systems: As with other penicillins, anemia, thrombocytopenia, leukopenia, neutropenia and eosinophilia.

Abnormalities of Blood, Hepatic and Renal Laboratory Studies: As with other semisynthetic penicillins, SGOT and SGPT elevations have been reported. To date, clinical manifestations of hepatic or renal disorders have not been observed which could be ascribed solely to Ticarcillin.

CNS: Patients, especially those with impaired renal function, may experience convulsions or neuromuscular excitability when very high doses of the drug are administered.

Other: Local reactions such as pain (rarely accompanied by induration) at the site of the injection have been reported. Vein irritation and phlebitis can occur, particularly when undiluted solution is directly injected into the vein.

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Side Effects by Body System - for Healthcare Professionals

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and pseudomembranous colitis.

Local

Local side effects have included injection site pain and induration. Vein irritation and phlebitis may occur when undiluted ticarcillin is injected directly.

Hypersensitivity

Hypersensitivity reactions have included skin rashes, pruritus, urticaria, drug fever, and anaphylaxis.

Metabolic

Some studies show a positive correlation between the degree of hypokalemia, the dose of ticarcillin, and the serum BUN/creatinine ratio, suggesting dehydration and higher doses are risk factors for the development of ticarcillin-associated hypokalemia.

Metabolic abnormalities have included hypernatremia and hypokalemia.

Hematologic

Hematologic side effects have included anemia, thrombocytopenia, leukopenia, neutropenia, and eosinophilia.

Hepatic

Hepatic side effects have included elevations of SGOT and SGPT.

Nervous system

Nervous system side effects may include convulsion or neuromuscular excitability with high doses.

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