Sylvant Side Effects

Generic Name: siltuximab

Note: This document contains side effect information about siltuximab. Some of the dosage forms listed on this page may not apply to the brand name Sylvant.

Some side effects of Sylvant may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Applies to siltuximab: intravenous powder for injection

General

The most common adverse reactions were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 63%)
Common (1% to 10%): Lower respiratory tract infection, oropharyngeal pain

Dermatologic

Very common (10% or more): Rash (28%), pruritus (28%)
Common (1% to 10%): Skin hyperpigmentation, eczema, psoriasis, dry skin

Gastrointestinal

Very common (10% or more): Diarrhea (up to 32%), abdominal pain/abdominal distention (12%)
Common (1% to 10%): Constipation
Frequency not reported: Gastrointestinal perforation

Metabolic

Very common (10% or more): Weight increased (19%), hyperuricemia (11%)
Common (1% to 10%): Hypertriglyceridemia, hypercholesterolemia, decreased appetite, dehydration

Cardiovascular

Very common (10% or more): Edema (26%)
Common (1% to 10%): Hypotension

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylactic reaction

Other

Infusion related reactions included back pain, chest pain/discomfort, nausea and vomiting, flushing, erythema, and palpitations.

Very common (10% or more): Fatigue (21%)
Common (1% to 10%): Infusion related reaction

Musculoskeletal

Very common (10% or more): Pain in extremities (21%), arthralgia (21%)

Renal

Common (1% to 10%): Renal impairment

Hematologic

Common (1% to 10%): Thrombocytopenia

Nervous system

Common (1% to 10%): Headache

Immunologic

Uncommon (0.1% to 1%): Positive test for anti-siltuximab (the active ingredient contained in Sylvant) antibodies

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