Sylvant Side Effects
Generic Name: siltuximab
Note: This document contains side effect information about siltuximab. Some of the dosage forms listed on this page may not apply to the brand name Sylvant.
Some side effects of Sylvant may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Applies to siltuximab: intravenous powder for injection
The most common adverse reactions were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.
Very common (10% or more): Upper respiratory tract infection (up to 63%)
Common (1% to 10%): Lower respiratory tract infection, oropharyngeal pain
Very common (10% or more): Rash (28%), pruritus (28%)
Common (1% to 10%): Skin hyperpigmentation, eczema, psoriasis, dry skin
Very common (10% or more): Diarrhea (up to 32%), abdominal pain/abdominal distention (12%)
Common (1% to 10%): Constipation
Frequency not reported: Gastrointestinal perforation
Very common (10% or more): Weight increased (19%), hyperuricemia (11%)
Common (1% to 10%): Hypertriglyceridemia, hypercholesterolemia, decreased appetite, dehydration
Very common (10% or more): Edema (26%)
Common (1% to 10%): Hypotension
Uncommon (0.1% to 1%): Anaphylactic reaction
Infusion related reactions included back pain, chest pain/discomfort, nausea and vomiting, flushing, erythema, and palpitations.
Very common (10% or more): Fatigue (21%)
Common (1% to 10%): Infusion related reaction
Very common (10% or more): Pain in extremities (21%), arthralgia (21%)
Common (1% to 10%): Renal impairment
Common (1% to 10%): Thrombocytopenia
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Positive test for anti-siltuximab (the active ingredient contained in Sylvant) antibodies
More about Sylvant (siltuximab)
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