Sylvant Side Effects

Generic Name: siltuximab

Note: This document contains side effect information about siltuximab. Some of the dosage forms listed on this page may not apply to the brand name Sylvant.

Some side effects of Sylvant may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Applies to siltuximab: intravenous powder for injection


The most common adverse reactions were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.


Very common (10% or more): Upper respiratory tract infection (up to 63%)
Common (1% to 10%): Lower respiratory tract infection, oropharyngeal pain


Very common (10% or more): Rash (28%), pruritus (28%)
Common (1% to 10%): Skin hyperpigmentation, eczema, psoriasis, dry skin


Very common (10% or more): Diarrhea (up to 32%), abdominal pain/abdominal distention (12%)
Common (1% to 10%): Constipation
Frequency not reported: Gastrointestinal perforation


Very common (10% or more): Weight increased (19%), hyperuricemia (11%)
Common (1% to 10%): Hypertriglyceridemia, hypercholesterolemia, decreased appetite, dehydration


Very common (10% or more): Edema (26%)
Common (1% to 10%): Hypotension


Uncommon (0.1% to 1%): Anaphylactic reaction


Infusion related reactions included back pain, chest pain/discomfort, nausea and vomiting, flushing, erythema, and palpitations.

Very common (10% or more): Fatigue (21%)
Common (1% to 10%): Infusion related reaction


Very common (10% or more): Pain in extremities (21%), arthralgia (21%)


Common (1% to 10%): Renal impairment


Common (1% to 10%): Thrombocytopenia

Nervous system

Common (1% to 10%): Headache


Uncommon (0.1% to 1%): Positive test for anti-siltuximab (the active ingredient contained in Sylvant) antibodies

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