Sylvant

Generic Name: siltuximab (sil TUX i mab)
Brand Names: Sylvant

What is Sylvant?

Sylvant (siltuximab) inhibits a certain protein in the body called interleukin-6 (IL-6). High levels of IL-6 can cause an overgrowth of cells in the lymph system (part of your immune system).

Sylvant is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.

Sylvant is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.

Important information

You should not use Sylvant if you have a severe infection. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).

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Before taking this medicine

You should not use Sylvant if you are allergic to siltuximab, or if you have a severe infection.

If you have a severe illness with fever or any type of infection, you may need to wait until you get better before receiving this medicine. Tell your doctor if you have recently had any signs of infection (fever, chills, body aches).

To make sure Sylvant is safe for you, tell your doctor if you have:

  • a recent or active infection;

  • a stomach or intestinal disorder, including ulcer or diverticulitis;

  • a history of stomach or intestinal bleeding;

  • gout; or

  • if you have recently received any vaccines, or if you are due to receive one.

FDA pregnancy category C. It is not known whether Sylvant will harm an unborn baby. Sylvant can affect the immune system of a newborn if the mother receives the medicine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control while you are using this medication and for at least 3 months after your treatment ends.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether siltuximab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Sylvant given?

Sylvant is injected into a vein through an IV. A healthcare provider will give you this injection once every 3 weeks. Follow your doctor's dosing instructions very carefully.

Before each injection, your doctor may perform blood tests to make sure you do not have conditions that would prevent you from safely using Sylvant.

Sylvant must be given slowly and the IV infusion can take at least 1 hour to complete.

Sylvant can lower blood cells that help your body fight infections. Your blood will need to be tested often. Your treatments may be delayed based on the results of these tests.

Sylvant dosing information

Usual Adult Dose for Castleman's Disease:

11 mg/kg intravenously over 1 hour every 3 weeks.

Duration of therapy: Until treatment failure.

Comments:
-Siltuximab was not studied in patients with MCD who are HIV positive or HHV-8 positive because siltuximab did not bind to virally produced IL-6 in a nonclinical study.


Use: Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Sylvant injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Sylvant?

Do not receive a "live" vaccine while using Sylvant. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Sylvant side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Sylvant: hives; chest tightness, difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy or light-headed, or have a chest tightness, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • signs of infection, such as fever, chills, painful mouth sores, pain when swallowing, cold or flu symptoms, cough, trouble breathing; or

  • signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; severe pain in your side or lower back.

Common Sylvant side effects may include:

  • weight gain;

  • itching or rash;

  • cold symptoms such as stuffy nose, sneezing, sore throat; or

  • high levels of uric acid in your blood (can lead to kidney problems or gout symptoms such as joint stiffness, pain, or swelling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Sylvant?

Other drugs may interact with siltuximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Sylvant.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sylvant only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.02. Revision Date: 2014-08-28, 9:49:48 AM.

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