Stay Awake Side Effects
Generic Name: caffeine
Note: This page contains side effects data for the generic drug caffeine. It is possible that some of the dosage forms included below may not apply to the brand name Stay Awake.
It is possible that some side effects of Stay Awake may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to caffeine: solution
As well as its needed effects, caffeine (the active ingredient contained in Stay Awake) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking caffeine, check with your doctor or nurse as soon as possible:More common
- fast heartbeat
- hyperglycemia, including blurred vision, drowsiness, dry mouth, flushed dry skin, fruit-like breath odor, increased urination, ketones in urine, loss of appetite, nausea, stomachache, tiredness, troubled breathing, unusual thirst, or vomiting (in newborn babies)
- hypoglycemia, including anxious feeling, blurred vision, cold sweats, confusion, cool pale skin, drowsiness, excessive hunger, fast heartbeat, nausea, nervousness, restless sleep, shakiness, or unusual tiredness or weakness (in newborn babies)
- irritability, nervousness, or severe jitters (in newborn babies)
- nausea (severe)
- trouble in sleeping
- Abdominal or stomach bloating
- diarrhea (bloody)
- unusual tiredness or weakness
- Abdominal or stomach pain
- agitation, anxiety, excitement, or restlessness
- confusion or delirium
- convulsions (seizures)—in acute overdose
- faster breathing rate
- fast or irregular heartbeat
- frequent urination
- increased sensitivity to touch or pain
- muscle trembling or twitching
- nausea and vomiting, sometimes with blood
- overextending the body with head and heels bent backward and body bowed forward
- painful, swollen abdomen or vomiting (in newborn babies)
- ringing or other sounds in ears
- seeing flashes of "zig-zag" lights
- whole-body tremors (in newborn babies)
Some caffeine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Nausea (mild)
- nervousness or jitters (mild)
After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this time, check with your doctor if you notice any of the following side effects:More common
- muscle tension
- stuffy nose
- unusual tiredness
For Healthcare Professionals
Applies to caffeine: compounding powder, intravenous solution, oral gum, oral liquid, oral tablet, oral tablet dispersible, oral tablet extended release
In general, consumption of higher doses of caffeine (the active ingredient contained in Stay Awake) (less than 600 mg/day) has been reported to have lead to caffeinism. Caffeinism is a syndrome characterized by anxiety, restlessness, and sleep disorders (similar to anxiety states). It has also been reported that chronic, heavy caffeine ingestion may be associated with depression. Caffeine may cause anxiety and panic in panic disorder patients and may aggravate premenstrual syndrome (PMS).
Two studies have shown that caffeine consumption is associated with a lower serum uric acid level and a lower risk of incident gout.
Gastrointestinal side effects associated with caffeine (the active ingredient contained in Stay Awake) citrate have included necrotizing enterocolitis in infants. Increased gastric aspirate and gastrointestinal intolerance have been reported rarely with caffeine products.
In clinical trials of caffeine citrate, six cases of necrotizing enterocolitis (3 fatal) were reported among 85 infants exposed to caffeine citrate injection, however, causality has not been established.
In one study of 634 women with fibrocystic breast disease (compared to 1066 women without the disease), the occurrence of fibrocystic breast disease was positively associated with average daily consumption of caffeine (the active ingredient contained in Stay Awake) Women who consumed 31 to 250 mg/day of caffeine were reported to have a 1.5 times increase in odds to have the disease. Women who consumed over 500 mg/day of caffeine were reported to have a 2.3 times increase in odds.
Other side effects associated with caffeine consumption have included fibrocystic breast disease in women.
One study has reported that while favorable subjective and performance-enhancing stimulant effects occur at low to intermediate caffeine doses, the unfavorable subjective and somatic effects, as well as performance disruption from high doses of caffeine may intrinsically limit the doses of caffeine used in the general population.
Psychiatric side effects have included confusion and psychotic symptoms.
Cardiovascular side effects associated with caffeine (the active ingredient contained in Stay Awake) products have rarely included tachycardia, increased left ventricular output, and increased stroke volume.
One study (n=77) reported increased blood pressure following caffeine intake (3.3 mg/kg) of approximately 4.5 mmHg in premenopausal women and 4.1 mmHg in men. Although men and women showed similar responses in blood pressure following consumption of a dietary dose of caffeine the hemodynamic mechanisms facilitating this change are different. Premenopausal women showed an increase in cardiac output whereas men showed increased vascular resistance.
One small study (n=12) reports caffeine to exert an acute unfavorable effect on aortic stiffness in treated hypertensive patients. This effect peaked approximately 60 minutes following administration of caffeine 250 mg orally, lasted a minimum duration of approximately 3 hours, and then decreased gradually.
Endocrine side effects associated with caffeine (the active ingredient contained in Stay Awake) products have rarely included alterations in serum glucose such as hypoglycemia and hyperglycemia.
Several studies report a decrease in insulin sensitivity in individuals following caffeine consumption. The mechanism leading to this effect is unknown but may be related to elevated serum epinephrine levels.
A few studies report a possible decreased risk of type 2 diabetes mellitus in individuals who consume coffee.
Nervous system side effects associated with caffeine (the active ingredient contained in Stay Awake) consumption have included central nervous system stimulation such as irritability, restlessness, and jitteriness.
Renal side effects associated with caffeine (the active ingredient contained in Stay Awake) consumption have included increased urine flow rate, creatinine clearance, and sodium and calcium excretion.
Genitourinary side effects associated with caffeine (the active ingredient contained in Stay Awake) products include urinary incontinence (UI) in men and women.
More about Stay Awake (caffeine)
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.