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Skelid Side Effects

Generic Name: tiludronate

Note: This page contains side effects data for the generic drug tiludronate. It is possible that some of the dosage forms included below may not apply to the brand name Skelid.

It is possible that some side effects of Skelid may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tiludronate: oral tablet

As well as its needed effects, tiludronate (the active ingredient contained in Skelid) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tiludronate, check with your doctor immediately:

More common
  • Cough
  • fever
  • head congestion
  • hoarseness or other voice changes
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
Less common
  • Blindness
  • blurred or decreased vision
  • burning, dry, or itching eyes
  • chest pain
  • discharge or excessive tearing
  • eye pain
  • headache
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling of the face, feet, or lower legs
  • unusual weight gain
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • feeling of constant movement of self or surroundings
  • frequent urge to urinate
  • headache
  • itching red skin lesions, often with a purple center
  • lower back or side pain
  • nervousness
  • pain or swelling in the arms or legs without any injury
  • pounding in the ears
  • sensation of spinning
  • slow or fast heartbeat
  • sores, ulcers, or white spots in the mouth or on the lips

If any of the following symptoms of overdose occur while taking tiludronate, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • confusion
  • convulsions
  • difficulty with breathing
  • irregular heartbeats
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • shortness of breath
  • tremor

Some tiludronate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • body pain (general)
  • diarrhea
  • nausea
  • upset stomach
Less common
  • Bone fractures
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • difficulty having a bowel movement (stool)
  • dizziness
  • dry skin
  • hair loss
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • muscle cramps or spasms
  • muscle pain
  • red or irritated eyes
  • skin rash
  • stomach gas
  • throat pain
  • tooth disorder
  • trouble thinking
  • vomiting
  • Dry mouth
  • fear or nervousness
  • feeling of warmth
  • lack or loss of strength
  • redness of the face, neck, arms and occasionally, upper chest
  • sleepiness or unusual drowsiness
  • stomach pain
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to tiludronate: oral tablet


The most frequently occurring adverse reactions reported were: Diarrhea (9.3%), nausea (9.3%), and dyspepsia (5.3%).[Ref]


Common (1% to 10%): Hypertension, flushing[Ref]


Common (1% to 10%): Rash, skin disorder, pruritus, increased sweating[Ref]


Common (1% to 10%): Hyperparathyroidism[Ref]


Common (1% to 10%): Diarrhea, nausea, dyspepsia, vomiting, flatulence, tooth disorder, abdominal pain, constipation, dry mouth gastritis[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Vitamin D deficiency, anorexia[Ref]


Common (1% to 10%): Arthralgia, back pain, arthrosis, fracture pathological, skeletal pain
Postmarketing reports: Atypical subtrochanteric and diaphyseal femoral fractures have been reported with bisphosphonate therapy, including this drug[Ref]

Bone, joint, and/or muscle pain, rarely severe and/or incapacitating have been reported.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, paresthesia, vertigo, involuntary muscle contractions, somnolence, nervousness[Ref]


Common (1% to 10%): Cataract, conjunctivitis, glaucoma[Ref]


Common (1% to 10%): Pain, accidental injury, influenza like symptoms, chest pain, peripheral edema, infection, asthenia, syncope, fatigue[Ref]


Common (1% to 10%): Insomnia, anxiety[Ref]


Common (1% to 10%): Rhinitis, sinusitis, upper respiratory tract infection, coughing, pharyngitis, bronchitis[Ref]


Rare (less than 0.1%): Stevens-Johnson syndrome[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Skelid (tilundronate)." Sanofi Winthrop Pharmaceuticals, New York, NY.

4. Lourwood DL "The pharmacology and therapeutic utility of bisphosphonates." Pharmacotherapy 18 (1998): 779-89

5. Roux C, Listrat V, Villette B, Lessana-Leibowitch M, Ethgen D, Pelissier C, Dougados M, Amor B "Long-lasting dermatological lesions after tiludronate therapy." Calcif Tissue Int 50 (1992): 378-80

6. Reginster JY, Lecart MP, Deroisy R, Ethgen D, Zegels B, Franchimont P "Paget's disease of bone treated with a five day course of oral tiludronate." Ann Rheum Dis 52 (1993): 54-7

7. Fraser WD, Stamp TC, Creek RA, Sawyer JP, Picot C "A double-blind, multicentre, placebo-controlled study of tiludronate in Paget's disease of bone." Postgrad Med J 73 (1997): 496-502

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