Skelid Side Effects

Generic Name: tiludronate

Note: This page contains side effects data for the generic drug tiludronate. It is possible that some of the dosage forms included below may not apply to the brand name Skelid.

It is possible that some side effects of Skelid may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tiludronate: oral tablet

As well as its needed effects, tiludronate (the active ingredient contained in Skelid) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tiludronate, check with your doctor immediately:

More common
  • Cough
  • fever
  • head congestion
  • hoarseness or other voice changes
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
Less common
  • Blindness
  • blurred or decreased vision
  • burning, dry, or itching eyes
  • chest pain
  • discharge or excessive tearing
  • eye pain
  • headache
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling of the face, feet, or lower legs
  • unusual weight gain
Rare
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • feeling of constant movement of self or surroundings
  • frequent urge to urinate
  • headache
  • itching red skin lesions, often with a purple center
  • lower back or side pain
  • nervousness
  • pain or swelling in the arms or legs without any injury
  • pounding in the ears
  • sensation of spinning
  • slow or fast heartbeat
  • sores, ulcers, or white spots in the mouth or on the lips

If any of the following symptoms of overdose occur while taking tiludronate, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • confusion
  • convulsions
  • difficulty with breathing
  • irregular heartbeats
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • shortness of breath
  • tremor

Some tiludronate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • body pain (general)
  • diarrhea
  • nausea
  • upset stomach
Less common
  • Bone fractures
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • difficulty having a bowel movement (stool)
  • dizziness
  • dry skin
  • hair loss
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • muscle cramps or spasms
  • muscle pain
  • red or irritated eyes
  • skin rash
  • stomach gas
  • throat pain
  • tooth disorder
  • trouble thinking
  • vomiting
Rare
  • Dry mouth
  • fear or nervousness
  • feeling of warmth
  • lack or loss of strength
  • redness of the face, neck, arms and occasionally, upper chest
  • sleepiness or unusual drowsiness
  • stomach pain
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to tiludronate: oral tablet

General

Adverse effects generally have been mild and have not required discontinuation of tiludronate (the active ingredient contained in Skelid) therapy. Gastrointestinal side effects including nausea (9%), diarrhea (9%) and dyspepsia ((5%) have occurred most frequently.

During clinical trials, symptoms such as general body pain, flu-like symptoms, headaches, dizziness, and arthralgias were reported more frequently in the placebo groups than in patients receiving tiludronate.

Gastrointestinal

Gastrointestinal (GI) side effects have been the most frequent side effects noted during tiludronate (the active ingredient contained in Skelid) therapy. (GI) side effects have included diarrhea and nausea (9%), dyspepsia (5%), vomiting (4%), flatulence and tooth disorder (3%). Abdominal pain, constipation, dry mouth, and gastritis have also been reported.

Renal

Tiludronate is not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min). A single oral dose of 400 mg of tiludronate (the active ingredient contained in Skelid) administered to patients with creatinine clearance between 11 and 18 mL/min resulted in an elimination half-life of 205 hours.

Cardiovascular

Cardiovascular side effects have included edema (3%)and chest pain (3%). Hypertension and flushing have been reported occasionally.

Nervous system

Nervous system side effects such as paresthesia (4%), vertigo, and involuntary muscle contraction have occurred. Nervous system side effects of headache and dizziness occurred less often in patients receiving tiludronate (the active ingredient contained in Skelid) when compared to patients in the placebo group (7% and 4% versus 12% and 7% respectively).

Endocrine

Endocrine side effects of hyperparathyroidism have occurred in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)

Metabolic

Metabolic side effects are uncommon. Vitamin D deficiency has occurred at a rate of 3% in treatment and placebo groups.

Musculoskeletal

Musculoskeletal symptoms of arthralgia were reported less frequently in tiludronate (the active ingredient contained in Skelid) treatment groups than were reported in placebo groups (3% versus 5%).

Musculoskeletal side effects such as arthrosis occurred in 3% of patients receiving tiludronate. Pathological fractures have been reported.

Immunologic

Unspecified infections have been reported in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)

Respiratory

Respiratory side effects including rhinitis and sinusitis (5%), coughing and pharyngitis (3%) have occurred. Bronchitis has also been reported.

Upper respiratory infections occurred at a frequency of 15% in patients in placebo groups compared to 5% in patients treated with tiludronate.

Dermatologic

Dermatologic side effects have included rash and unspecified skin disorders in 3% of patients receiving tiludronate (the active ingredient contained in Skelid) Pruritus and diaphoresis have been reported.

Ocular

Ocular side effects have included cataracts, conjunctivitis, or glaucoma in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)

Genitourinary

Genitourinary side effects have been uncommon. Urinary tract infections occasionally have been reported.

Hypersensitivity

Hypersensivity reactions have been rare. Stevens-Johnson Syndrome has been reported, however, causality has not been established.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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