Skelid Side Effects
Generic name: tiludronate
Note: This document contains side effect information about tiludronate. Some of the dosage forms listed on this page may not apply to the brand name Skelid.
Some side effects of Skelid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to tiludronate: oral tablet
Along with its needed effects, tiludronate (the active ingredient contained in Skelid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tiludronate:More common
- head congestion
- hoarseness or other voice changes
- nasal congestion
- runny nose
- sore throat
- blurred or decreased vision
- burning, dry, or itching eyes
- chest pain
- discharge or excessive tearing
- eye pain
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- swelling of the face, feet, or lower legs
- unusual weight gain
- Bladder pain
- blistering, peeling, or loosening of the skin
- bloody or cloudy urine
- difficult, burning, or painful urination
- dizziness or lightheadedness
- feeling of constant movement of self or surroundings
- frequent urge to urinate
- itching red skin lesions, often with a purple center
- lower back or side pain
- pain or swelling in the arms or legs without any injury
- pounding in the ears
- sensation of spinning
- slow or fast heartbeat
- sores, ulcers, or white spots in the mouth or on the lips
Get emergency help immediately if any of the following symptoms of overdose occur while taking tiludronate:Symptoms of overdose
- Abdominal or stomach cramps
- difficulty with breathing
- irregular heartbeats
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- numbness and tingling around the mouth, fingertips, or feet
- shortness of breath
Some side effects of tiludronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- body pain (general)
- upset stomach
- Bone fractures
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- difficulty having a bowel movement (stool)
- dry skin
- hair loss
- increased thirst
- increased urination
- joint pain
- loss of appetite
- muscle cramps or spasms
- muscle pain
- red or irritated eyes
- skin rash
- stomach gas
- throat pain
- tooth disorder
- trouble thinking
- Dry mouth
- fear or nervousness
- feeling of warmth
- lack or loss of strength
- redness of the face, neck, arms and occasionally, upper chest
- sleepiness or unusual drowsiness
- stomach pain
- trouble sleeping
- unable to sleep
- unusual tiredness or weakness
For Healthcare Professionals
Applies to tiludronate: oral tablet
During clinical trials, symptoms such as general body pain, flu-like symptoms, headaches, dizziness, and arthralgias were reported more frequently in the placebo groups than in patients receiving tiludronate (the active ingredient contained in Skelid)
Adverse effects generally have been mild and have not required discontinuation of tiludronate therapy. Gastrointestinal side effects including nausea (9%), diarrhea (9%) and dyspepsia ((5%) have occurred most frequently.
Gastrointestinal (GI) side effects have been the most frequent side effects noted during tiludronate (the active ingredient contained in Skelid) therapy. (GI) side effects have included diarrhea and nausea (9%), dyspepsia (5%), vomiting (4%), flatulence and tooth disorder (3%). Abdominal pain, constipation, dry mouth, and gastritis have also been reported.
Tiludronate is not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min). A single oral dose of 400 mg of tiludronate (the active ingredient contained in Skelid) administered to patients with creatinine clearance between 11 and 18 mL/min resulted in an elimination half-life of 205 hours.
Cardiovascular side effects have included edema (3%)and chest pain (3%). Hypertension and flushing have been reported occasionally.
Nervous system side effects such as paresthesia (4%), vertigo, and involuntary muscle contraction have occurred. Nervous system side effects of headache and dizziness occurred less often in patients receiving tiludronate (the active ingredient contained in Skelid) when compared to patients in the placebo group (7% and 4% versus 12% and 7% respectively).
Endocrine side effects of hyperparathyroidism have occurred in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)
Metabolic side effects are uncommon. Vitamin D deficiency has occurred at a rate of 3% in treatment and placebo groups.
Musculoskeletal symptoms of arthralgia were reported less frequently in tiludronate (the active ingredient contained in Skelid) treatment groups than were reported in placebo groups (3% versus 5%).
Musculoskeletal side effects such as arthrosis occurred in 3% of patients receiving tiludronate. Pathological fractures have been reported.
Unspecified infections have been reported in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)
Upper respiratory infections occurred at a frequency of 15% in patients in placebo groups compared to 5% in patients treated with tiludronate (the active ingredient contained in Skelid)
Respiratory side effects including rhinitis and sinusitis (5%), coughing and pharyngitis (3%) have occurred. Bronchitis has also been reported.
Dermatologic side effects have included rash and unspecified skin disorders in 3% of patients receiving tiludronate (the active ingredient contained in Skelid) Pruritus and diaphoresis have been reported.
Ocular side effects have included cataracts, conjunctivitis, or glaucoma in 3% of patients receiving tiludronate (the active ingredient contained in Skelid)
Genitourinary side effects have been uncommon. Urinary tract infections occasionally have been reported.
Hypersensivity reactions have been rare. Stevens-Johnson Syndrome has been reported, however, causality has not been established.
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