Pomalidomide Side Effects

It is possible that some side effects of pomalidomide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pomalidomide: oral capsule

As well as its needed effects, pomalidomide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pomalidomide, check with your doctor immediately:

More common
  • Abdominal or stomach pain
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bloody nose
  • body aches or pain
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • cloudy urine
  • confusion
  • constipation
  • cough
  • decreased or increased urination
  • depression
  • difficult, burning, or painful urination
  • difficulty with breathing
  • dizziness
  • dry mouth
  • ear congestion
  • fast or irregular heartbeat
  • fever
  • frequent urge to urinate
  • headache
  • incoherent speech
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • metallic taste
  • muscle pain or cramps
  • muscle weakness
  • nasal congestion
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pain
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • runny nose
  • shakiness in the legs, arms, hands, or feet
  • sneezing
  • sore throat
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet
Less common
  • Anxiety
  • dizziness or lightheadedness
  • fainting
  • pain, redness, or swelling in the arm or leg
  • sudden shortness of breath or troubled breathing
Incidence not known
  • Difficulty in passing urine (dribbling)
  • weakness or heaviness of the legs
  • yellow eyes or skin

Some pomalidomide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • blurred vision
  • decreased appetite
  • difficulty with moving
  • dry skin
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased sweating
  • joint pain
  • lack or loss of strength
  • muscle spasms or stiffness
  • night sweats
  • rash
  • trouble sleeping
Incidence not known
  • Feeling of constant movement of self or surroundings
  • sensation of spinning

For Healthcare Professionals

Applies to pomalidomide: oral capsule

Cardiovascular

Frequency not reported: Atrial fibrillation, congestive heart failure

Dermatologic

Very common (10% or more): Rash (19%), pruritus (13%), hyperhidrosis (11%), dry skin (10%)
Common (1% to 10%): Night sweats (9%)

Gastrointestinal

Very common (10% or more): Constipation (35%), diarrhea (33%), nausea (29%), vomiting (14%)

General

Very common (10% or more): Fatigue and asthenia (59%), pyrexia (25%), peripheral edema (20%), chills (10%), pain (5%)
Frequency not reported: Sepsis, neutropenic sepsis

Genitourinary

Very common (10% or more): Urinary tract infection (12%)
Frequency not reported: Pelvic pain

Hematologic

Very common (10% or more): Neutropenia (50%), anemia (39%), thrombocytopenia (24%), leukopenia (15%), lymphopenia (10%)
Frequency not reported: Febrile neutropenia

Hepatic

Frequency not reported: Hyperbilirubinemia, alanine aminotransferase increased

Metabolic

Very common (10% or more): Decreased appetite (20%), hypercalcemia (16%), hyperglycemia (14%), increased serum creatinine (13%), hyponatremia (11%), hypokalemia (11%), weight decreased (11%)
Common (1% to 10%): Hypocalcemia (9%), weight increased (6%)
Frequency not reported: Dehydration, hyperkalemia

Musculoskeletal

Very common (10% or more): Back pain (31%), musculoskeletal chest pain (21%), muscle spasms (19%), arthralgia (16%), musculoskeletal pain (13%), pain in extremity (10%), muscular weakness (12%)
Common (1% to 10%): Bone pain (8%)
Frequency not reported: Alanine aminotransferase increased

Nervous system

Very common (10% or more): Dizziness (18%), tremor (11%), headache (11%)
Common (1% to 10%): Peripheral neuropathy (9%)
Frequency not reported: Vertigo

Psychiatric

Very common (10% or more): Insomnia (11%), confusional state (12%), anxiety (9%)

Renal

Very common (10% or more): Renal failure (12%)

Respiratory

Very common (10% or more): Dyspnea (39%), upper respiratory infection (28%), pneumonia (26%), cough (17%), epistaxis (13%)
Frequency not reported: Respiratory syncytial virus infection, Pneumocystis jiroveci pneumonia, interstitial lung disease

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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