Nuvigil Side Effects
Generic name: armodafinil
Note: This document contains side effect information about armodafinil. Some of the dosage forms listed on this page may not apply to the brand name Nuvigil.
Some side effects of Nuvigil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to armodafinil: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking armodafinil (the active ingredient contained in Nuvigil) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using armodafinil and call your doctor at once if you have a serious side effect such as:
fever, sore throat, headache, and vomiting with a severe blistering, peeling, and red skin rash;
the first sign of any type of skin rash, no matter how mild;
bruising, severe tingling, numbness, pain, muscle weakness;
easy bruising or bleeding;
mouth sores, trouble swallowing;
upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
depression, confusion, hallucinations, aggression, unusual thoughts or behavior;
chest pain, uneven heart beats.
Less serious side effects of armodafinil may include:
feeling nervous or anxious;
nausea, diarrhea, upset stomach;
trouble sleeping (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to armodafinil: oral tablet
In general, armodafinil (the active ingredient contained in Nuvigil) has been well tolerated and most side effects have been mild to moderate in severity.
Cardiovascular side effects have included palpitations (2%) and tachycardia (1%).
Gastrointestinal side effects have frequently included nausea (7%), diarrhea (4%), dry mouth (4%), dyspepsia (2%), and upper abdominal pain (2%). Constipation, vomiting, anorexia, decreased appetite, and loose stools have been reported in 1% of patients.
Nervous system side effects have included headache (17%), dizziness (5%), insomnia (5%), tremor (1%), migraine headache (1%), paresthesia (1%), and disturbance in attention (1%).
Other side effects have included fatigue (2%), thirst (1%), influenza-like illness (1%), fever (1%), and pain (1%).
Psychiatric side effects have included anxiety (4%), depression (2%), agitation (1%), nervousness (1%), and depressed mood (1%). Postmarketing adverse events associated with the use of modafinil have included aggression.
Genitourinary side effects have included polyuria (1%).
Respiratory side effects have included dyspnea (1%).
Dermatologic side effects have included rash (2%), contact dermatitis (1%), and hyperhydrosis (1%). Serious rash requiring hospitalization and discontinuation of treatment has been reported in adults in association with the use of modafinil and armodafinil (the active ingredient contained in Nuvigil)
Hematologic side effects include a single case of mild pancytopenia that resolved following discontinuation of armodafinil (the active ingredient contained in Nuvigil)
More Nuvigil resources
- Nuvigil Prescribing Information (FDA)
- Nuvigil Consumer Overview
- Nuvigil Monograph (AHFS DI)
- Nuvigil Advanced Consumer (Micromedex) - Includes Dosage Information
- Nuvigil MedFacts Consumer Leaflet (Wolters Kluwer)
- Armodafinil Professional Patient Advice (Wolters Kluwer)
- Armodafinil Prescribing Information (FDA)
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