Medication Guide App

Neupro Side Effects

Generic Name: rotigotine

Note: This page contains side effects data for the generic drug rotigotine. It is possible that some of the dosage forms included below may not apply to the brand name Neupro.

It is possible that some side effects of Neupro may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to rotigotine: transdermal patch extended release

As well as its needed effects, rotigotine (the active ingredient contained in Neupro) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking rotigotine, check with your doctor immediately:

More common
  • Burning, itching, redness, skin rash, swelling, or soreness at the application site
  • swelling of the hands, ankles, feet, or lower legs
Less common
  • Bladder pain
  • bloody or cloudy urine
  • blurred vision or other changes in vision
  • difficult, burning, or painful urination
  • dizziness
  • frequent urge to urinate
  • headache
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • seeing, hearing, or feeling things that are not there
  • slow or fast heartbeat

If any of the following symptoms of overdose occur while taking rotigotine, get emergency help immediately:

Symptoms of overdose
  • Confusion
  • convulsions
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some rotigotine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Sleepiness or unusual drowsiness
Less common
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dreaming abnormal
  • dry mouth
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • loss of appetite
  • muscle pain or stiffness
  • pain in the joints
  • sensation of spinning
  • sleeplessness
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • unable to sleep
  • weight loss

For Healthcare Professionals

Applies to rotigotine: transdermal film extended release


Cardiovascular side effects have included increased heart rate (9%), orthostatic hypotension (5% to 22%), increased blood pressure (4% to 9%), chest pain (greater than 2%), extremity edema (2% or greater), hypertension (2% or greater), syncope (1%), cardiac failure (0.1% to 1%), AV block (0.1% to 1%), bundle branch block (0.1% to 1%), atrial fibrillation (0.1% to 1%), ventricular arrhythmia (less than 0.1%), and ventricular tachycardia (less than 0.1%).[Ref]


Gastrointestinal side effects have included nausea (2% to 5% or greater), vomiting (2% to 5% or greater), constipation (2% or greater), dyspepsia (2% or greater), and anorexia (2% or greater).[Ref]

Nervous system

Nervous system side effects have included somnolence (5% or greater), insomnia (5% or greater), dizziness (2% to 5% or greater), headache (2% to 5% or greater), tremor (greater than 2%), increased sweating (2% or greater), vertigo (2% or greater), dry mouth (2% or greater), paresthesia (1%), confusion (1%), ataxia (1%), abnormal gait (1%), neuralgia (1%), hypesthesia (1%), hypertonia (1%), increased saliva (0.1% to 1%), increased appetite (0.1% to 1%), impotence (0.1% to 1%), flushing (0.1% to 1%), and convulsions (less than 0.1%). Dyskinesia has been reported (0.5%).[Ref]


Musculoskeletal side effects have included back pain (2% or greater), arthralgia (2% or greater), and myalgia.[Ref]


Respiratory side effects have included cough (greater than 2%), respiratory tract infection (greater than 2%), rhinitis (greater than 2%), and sinusitis (2% or greater).[Ref]


Ocular side effects have included abnormal vision (2% or greater) and photopsia (0.1% to 1%).[Ref]


Genitourinary side effects have included micturition frequency (greater than 2%), urinary tract infection (2% or greater), and urinary incontinence (1%).[Ref]


Hypersensitivity side effects have included allergic reactions (0.1% to 1%).[Ref]


Hepatic side effects have included increased gamma-glutamyl transferase (1%).[Ref]


Metabolic side effects have included weight gain (1%), weight loss, and decreased blood glucose.[Ref]


Renal side effects have included increased BUN.[Ref]


Hematological side effects have included thrombocytopenia (0.1% to 1%) and decreased hemoglobin.[Ref]


Dermatological side effects have included erythematous rash (2% or greater), contact dermatitis (1%), pruritus (1%), and purpura (1%).[Ref]


Psychiatric side effects have included anxiety (greater than 2%), depression (greater than 2%), somnolence (2% or greater), insomnia (2% or greater), abnormal dreaming (2% or greater), hallucinations (2% or greater), paranoid reaction (0.1% to 1%), and psychosis (0.1% to 1%).[Ref]


Local side effects have included application site reactions (2% to 5% or greater).[Ref]


Other side effects have included abdominal pain (greater than 2%), influenza like symptoms (greater than 2%), asthenia (greater than 2%), fall (greater than 2%), fatigue (2% or greater), accident NOS (2% or greater), leg pain (1%), malaise (1%), fever (1%), rigors (0.1% to 1%), hot flushes (0.1% to 1%), hyperesthesia (0.1% to 1%), and tinnitus (0.1% to 1%).[Ref]


1. "Product Information. Neupro (rotigotine)." Schwarz Pharma, Mequon, WI.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.