The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
pramipexole for Restless Legs Syndrome: I've dealt with 10+ years of restless legs and arms to the point I'd be in tears and have actually fallen out of my king sized bed. After trials of numerous medications (Ambien, Lunesta, leviteracetam, tranquilizers, mega vitamins) and months of little to no sleep I went begging for help to my GP. i was desperate at that point. With nothing else to try he sent me to a neurologist who specialized in sleep disorders and RLS. She started me on melatonin 1 mg at 6 pm, 5 mg at sleep along with pramipexole 0.25 mg in late afternoon if needed and 0.5 mg at 9 PM. WOW. Within one week I was getting far more sleep than I've seen in at least 2 years.
Mirapex (pramipexole) for Periodic Limb Movement Disorder: I have been taking Mirapex for a number of years, and it has worked best for me. I take 1 tab during day, 2 in early evenings.
I had taken a high does of gabapentin/Neutontin, but some suppliers have a huge pill that was just too difficult for me to take.
Review by it's complicated (taken for 1 to 2 years):
pramipexole for Restless Legs Syndrome: Started using pramipexole when weaning from zolpidem at sleep clinic. Long term insomnia complicated by shift work/school/age/family history. Pramipexole at 0.125mg/qd worked for about 9 months. Less effective if taken with food. Now, after a year, about 3 X week, first dose insufficient, so I take a second and that works. No side effects in gastrointestinal or balance/reaction time.
Mirapex (pramipexole) for Parkinson's Disease: I was recently diagnosed with Parkinson's disease. I was started on Mirapex, after 3 weeks of therapy I had to stop due to severe side effects: auditive hallucinations, nausea, peripheral edema, muscle pain, vivid dreams and the worst, difficulty sleeping having the need to get up and move constantly.
I'm sure that this is a very good medication but I couldn't tolerate the side effects
Mirapex (pramipexole) for Restless Legs Syndrome: It takes care of the Restless Legs Syndrome symptoms but also seems to give me insomnia, which kind of defeats the purpose. I can initially go to sleep and get a 3-4 hours but then I'm suddenly wide awake. Requip worked for a while but you have to increase dosage fairly quickly and that causes some bad side effects. I may have to try a 3rd option.
34 users found this comment helpful.
Review by jdswanberg (taken for 6 months to 1 year):
pramipexole for Restless Legs Syndrome: I had suffered restless legs syndrome periodically for many years. Then, suddenly, I was getting RLS every night. The weird thing, to me, is that I also had the feelings in my arms, but certainly not as frequently as the legs. After weeks of trying to reposition my legs, ignoring it (impossible!), I finally went to my doctor. I took my first dose that night, and haven't had symptoms ever since. I read up on the long-term usage, and am a little concerned about it. I'll cross that bridge if and when I cross it.
14 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: Delighted to hear others have benefited by taking Mirapex, I have had very mixed results. It certainly has alleviated my symptoms connected with Restless Legs Syndrome. But the relief came with a price. I became so nauseated that I was up all night, so after three nights I had to stop taking the medicine. I found Percocet the ideal replacement.
16 users found this comment helpful.
Review by SWS Canadian (taken for 10 years or more):
Mirapex (pramipexole) for Restless Legs Syndrome: I was diagnosed with Restless Legs Syndrome back in the '90's. I was first prescribed levodopa/carbidopa and it was wonderful at first. However it started losing effectiveness and making me sick during the day at times. Then a new medicine came out- Mirapex and I was put on it at 0.25mg before bedtime. It worked well for several years but had to be upped to 0.5mg. I found that Mirapex controlled my RLS fairly well and I was on it for 12 years! The last year I forced myself to cut back to 0.25mg again and put up with some symptoms. Then, I recently stopped taking it altogether. I have been taking strong vitamin supplements, but they didn't stop the RLS. However, when I started taking Magnesium, Potassium, and Calcium, and bathing in bath salts the RLS has disappeared.
67 users found this comment helpful.
Review by this works for me. (taken for 1 to 6 months):
Mirapex (pramipexole) for Restless Legs Syndrome: I started getting Restless Legs Syndrome in 2010, caught me off guard. I was taking Requip, and that worked for awhile, but I found that I was getting leg shaking during the day. Since I sit at a computer all day, this was very annoying and would actually interfere with my job. So I started taking the Requip during the day to alleviate the shaking, that made me very tired.
I went to a neurologist, and he changed my script to Mirapex. The 1st night was wonderful, the next full day, I was sleepy.
He had put me on 0.5 tabs 3x a day. I found that if I cut a tab into quarters, I could take 1/4 during the day with miminal sleepiness, and 1/2 tab at night when I wanted to sleep real good. So I end up taking the pill just 2x a day.
26 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: This medication has been so extremely helpful to me. After years of having restless legs syndrome (it runs in our family) I have been able to sleep at nights. Thanks goodness for this medication.
33 users found this comment helpful.
Mirapex (pramipexole) for Periodic Limb Movement Disorder: I had terrible side effects on this medicine. I was over active and couldn't stop making things, knitting, etc. all through the night . I couldn't sleep and my balance was off. I fell in the shower and hurt my neck. This was a terrible time for me.
18 users found this comment helpful.
Mirapex ER (pramipexole) for Parkinson's Disease: Mirapex was prescribed on Dec. 3, 2012, for my stage II Parkinson's Disease. From the first week (0.375mg only), all but a few of my symptoms were mitigated. Only a few minor side effects, which disappeared once I went to 0.75 MG for a week. Now at 1.5 MG. Easy to take, easy to swallow. I take after I've eaten a banana or piece of bread to avoid nausea.
15 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: Restless legs syndrome is a hard problem to deal with. Mirapex seems like a God send. But like most things it comes with a cost. First was the dollar cost which over the last 6 years has gone up considerably. The next price you pay is from side effects. Falling asleep while talking to someone is embarrassing and dangerous. But I've found a wonderful fix. While at the doctors I had to use a Doctor's Assistant (who was playing on her cell phone while talking to me). She gave me a prescription for Mirapex that is time released and you only take it at night just before bed time. My energy level has increased 10x and I don't fall asleep while dinning out with my wife. Blessed by Doctor%u2019s Assistant and her playing on the cell phone actually was searching on the intranet for something to help with the problem.
41 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: Mirapex (Pramipexole) is truly a wonder, it takes away 99% of my symptoms if taken early evening. I've used it for 10 years or more now and it hasn't failed me until lately, as my dose is now at 1mg at night and 0.5mg in the morning. My symptoms do come up early enough to get me out of bed in the morning once in a rare while.
29 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: I have been taking Mirapex for 7 or 8 yrs, I am now up to 0.50 to 0.75 it has worked well for me, except I have gained a lot of weight, and now I am having augmentation, meaning my legs start jerking earlier in the day and my arms are starting to have it. I can't increase it much more, too much fatigue, I am concerned about what I am going to take now. I've tried other things that don't work so beware of dopamine agonists after so many years you become immune to it unfortunately. I could not afford it if I had not qualified for patient assistance program, I don't have insurance.
23 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: I have had restless legs syndrome for many years. The first medicine I started to take was Klonopin which worked okay, but about 10 years ago I changed to Mirapex. It is such a great medicine for this problem that if I happen to forget to take it, as I do a few times a year, I totally freak out and panic. Once I was on a trip and realized I'd forgotten this medicine and was in a panic. Without this medicine my nights would all be a nightmare. With this drug I have no problems with my legs and no side effects. Thanks to whoever came up with this miracle.
39 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: Evidently my restless legs syndrome is worse than most. I take 1 Mirapex ER, but sometimes I need to take another. I am much better off with the medicine. I could not sleep without it.
21 users found this comment helpful.
Mirapex (pramipexole) for Restless Legs Syndrome: This somewhat reduced my restless legs syndrome (which occurs every other day and is enough to keep me up at night and be bothersome); however, this gave me insomnia, specifically causing me trouble falling asleep and once I was finally able to fall asleep, I would wake up once every two hours or so.
29 users found this comment helpful.
pramipexole for Restless Legs Syndrome: I have been taking 0.125mg pramipexole for over 5 months to treat restless legs syndrome, which I have for more than 10 years. It does work, gives you peaceful sleep, feeling great in the morning, no side effects. However, the question is: does it really treat the problem completely? I don't think so. I decided to discontinue pramipexole to see if I can cope without it and all symptoms came back following night. It looks like that either you would have to take it for the rest of your life or fight with restless legs syndrome. Since nowadays pramipexole is an effective way to temporarily alleviate restless legs syndrome. I have no other option as to keep taking it and hope for the best. But I don't really want to take it for the rest of my life.
Mirapex (pramipexole) for Restless Legs Syndrome: I have been taking Mirapex for a couple of weeks now. It doesn't seem to be helping that much just yet. I was diagnosed with restless legs syndrome about 6 years ago, which was a problem at night time. In October, I suddenly started having severe symptoms during the day, so I went to my doctor and she put me on Mirapex 0.125mg a day. I have noticed that I will suddenly feel very sleepy at times, while I've just been completely alert, which I see might be from the medication. Hopefully, with time it will relieve my symptoms for good!
11 users found this comment helpful.
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