Pramipexole Dosage

This dosage information may not include all the information needed to use Pramipexole safely and effectively. See additional information for Pramipexole.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Parkinson's Disease

Pramipexole immediate-release:
Initial dose: 0.125 mg orally three times a day with or without food.
Maintenance dose: The dosage should be titrated gradually to the desired clinical effect. Generally, the dosage may be increased every 5 to 7 days based on efficacy and tolerability, up to a maximum of 4.5 mg/day (given as 1.5 mg three times a day). The efficacy of dosages beyond 4.5 mg/day has not been established.

Pramipexole extended-release:
Initial dose: 0.375 mg once daily with or without food.
Maintenance dose: The dosage should be titrated gradually to the desired clinical effect. Generally, the dosage may be increased every 5 to 7 days based on efficacy and tolerability, first to 0.75 mg per day and then by 0.75 mg increments up to a maximum recommended dose of 4.5 mg per day. The efficacy of dosages beyond 4.5 mg/day has not been established.

Usual Adult Dose for Restless Legs Syndrome

Pramipexole immediate-release:
Initial dose: 0.125 mg orally once a day 2 to 3 hours before bedtime. If needed, dose may be titrated upwards by increments of 0.125 mg every 4 to 7 days.
Maintenance dose: 0.5 mg orally once a day 2 to 3 hours before bedtime.

Pramipexole extended-release is not indicated for Restless Legs Syndrome.

Renal Dose Adjustments

Parkinson's Disease:

Pramipexole immediate-release:

CrCl greater than 60 mL/min:
Initial dose: 0.125 three times a day
Maximum dose: 1.5 mg orally three times a day

CrCl 35 mL/min to 59 mL/min:
Initial dose: 0.125 mg orally twice a day
Maximum dose: 1.5 mg orally twice a day

CrCl 15 mL/min to 34 mL/min:
Initial dose: 0.125 mg orally once a day
Maximum dose: 1.5 mg orally once a day

CrCl less than 15 mL/min: Pramipexole immediate-release has not been adequately studied in the treatment of patients with severe renal impairment. There is insufficient information in the medical literature to recommend a safe dosage.

Pramipexole sustained-release:

CrCl greater than 50 mL/min: No reduction in daily dose is required.

CrCl 30 mL/min to 50 mL/min: Pramipexole extended-release should initially be taken every other day. Caution should be exercised and careful assessment of therapeutic response and tolerability should be made before increasing to daily dosing after one week, and before any additional titration in 0.375 mg increments up to 2.25 mg per day. Dose adjustment should occur no more frequently than at weekly intervals.

CrCl less than 30 mL/min: Pramipexole extended-release has not been adequately studied in the treatment of patients with severe renal impairment. There is insufficient information in the medical literature to recommend a safe dosage.

Restless Legs Syndrome:

Pramipexole immediate release:

CrCl 20 mL/min to 60 mL/min: The time interval between titration steps should be increased to 14 days.

CrCl less than 20 mL/min: Pramipexole has not been adequately studied in the treatment of patients with severe renal impairment. There is insufficient information in the medical literature to recommend a safe dosage.

Liver Dose Adjustments

Data not available

Dose Adjustments

If the patient is receiving levodopa, a reduction in the dosage of levodopa should be considered.

Patients may be switched overnight from pramipexole immediate-release to pramipexole extended-release at the same daily dose. Dose adjustment may be needed in some patients.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Pramipexole immediate-release and sustained-release have not been studied in patients on hemodialysis, and is not recommended in these patients.

Other Comments

Pramipexole immediate-release and sustained-release may be taken with or without food.

When discontinuing pramipexole immediate-release or extended-release, it should be done gradually over a period of one week.

Learn how medication, diet, and exercise are key to managing Multiple Sclerosis. Click Here

Close
Hide
(web1)