Midol IB Side Effects

Generic name: ibuprofen

Medically reviewed by Drugs.com. Last updated on Jul 31, 2024.

Note: This document provides detailed information about Midol IB Side Effects associated with ibuprofen. Some dosage forms listed on this page may not apply specifically to the brand name Midol IB.

Applies to ibuprofen: intravenous solution.

Other dosage forms:

• oral capsule liquid filled, oral suspension, oral tablet, oral tablet chewable

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

NSAIDs increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal.

Ibuprofen is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

NSAIDs also cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

Risk is especially increased in the elderly and in patients with prior peptic ulcer disease or GI bleeding.

Serious side effects of Midol IB

Along with its needed effects, ibuprofen (the active ingredient contained in Midol IB) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ibuprofen:

More common

• black, tarry stools
• bleeding gums
• blurred vision
• chest pain or tightness
• confusion
• cough
• coughing up blood
• decreased urine
• diarrhea
• difficulty with breathing or swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fast heartbeat
• fever or chills
• headache
• increased menstrual flow or vaginal bleeding
• increased thirst
• irregular heartbeat
• irritability
• loss of appetite
• lower back or side pain
• muscle pain, cramps, or twitching
• nausea or vomiting
• nervousness
• nosebleeds
• numbness or tingling in the hands, feet, or lips
• pain, warmth, or burning in the fingers, toes, and legs
• painful or difficult urination
• pale skin
• paralysis
• pounding in the ears
• problems with vision or hearing
• prolonged bleeding from cuts
• rapid breathing
• red or black, tarry stools
• red or dark brown urine
• restlessness
• seizures
• slow or fast heartbeat
• sneezing
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• sweating
• swelling of the feet or lower legs
• swollen glands
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common

• bloating or swelling of the face, arms, hands, lower legs, or feet
• decrease in the frequency of urination
• decrease in urine volume
• difficulty in passing urine (dribbling)
• rapid weight gain
• unusual weight gain or loss

Other side effects of Midol IB

Some side effects of ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• excess air or gas in the stomach or intestines
• full feeling
• passing gas

Less common

• acid or sour stomach
• belching
• heartburn
• indigestion
• stomach discomfort, upset, or pain

For healthcare professionals

Applies to ibuprofen: compounding powder, intravenous solution, oral capsule, oral suspension, oral tablet, oral tablet chewable.

General

The most frequently reported adverse effects were gastrointestinal (GI) in nature and included nausea, vomiting, flatulence, and diarrhea.

Patent Ductus Arteriosus: The most frequently reported adverse effects were sepsis, anemia, intraventricular bleeding, apnea, GI disorders, impaired renal function, respiratory infection, skin lesions, hypoglycemia, hypocalcemia, and respiratory failure.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 57%), vomiting (up to 22%), flatulence (up to 16%), diarrhea (up to 10%)
• Common (1% to 10%): Dyspepsia, abdominal discomfort, epigastric pain, heartburn, abdominal distress, indigestion, constipation, abdominal cramps/pain, fullness of GI tract, bloating, GI hemorrhage, melena
• Uncommon (0.1% to 1%): Abdominal distention, dyspepsia, gastritis
• Very rare (less than 0.01%): Peptic ulcer, perforation, hematemesis, mouth ulceration, exacerbation of colitis, exacerbation of Crohn's disease
• Frequency not reported: Dry mouth, duodenitis, esophagitis, gastric ulcer, duodenal ulcer, GI bleeding, glossitis, rectal bleeding, stomatitis, eructation, gingival ulcer, pancreatitis

Patent Ductus Arteriosus:

• Very common (10% or more): GI disorders non-necrotizing enterocolitis (22%)
• Common (1% to 10%): Necrotizing enterocolitis, intestinal perforation
• Frequency not reported: Abdominal distension, gastroesophageal reflux, gastritis, ileus, inguinal hernia
• Postmarketing reports: GI perforation^[Ref]

Cardiovascular

• Very common (10% or more): Hemorrhage (up to 10%), hypertension (10%), hypotension (10%)
• Very rare (less than 0.01%): Cardiac failure
• Frequency not reported: Congestive heart failure, tachycardia, arrhythmia, myocardial infarction, palpitations, vasculitis, sinus bradycardia, angina pectoris, thrombotic events

Patent Ductus Arteriosus:

• Frequency not reported: Tachycardia, cardiac failure, hypotension^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 12%)
• Common (1% to 10%): Dizziness, nervousness
• Very rare (less than 0.01%): Cerebrovascular accident
• Frequency not reported: Syncope, drowsiness, paresthesia, somnolence, tremors, convulsions, coma

Patent Ductus Arteriosus:

• Common (1% to 10%): Intraventricular hemorrhage, periventricular hemorrhage
• Frequency not reported: Convulsions^[Ref]

Renal

• Very rare (less than 0.01%): Acute renal failure, renal papillary necrosis, interstitial nephritis, nephrotic syndrome, renal failure, renal insufficiency
• Frequency not reported: Cystitis, azotemia, creatinine clearance decreased, glomerulitis, tubular necrosis, nephrotoxicity

Patent Ductus Arteriosus:

• Very common (10% or more): Renal events (21%)
• Uncommon (0.1% to 1%): Acute renal failure^[Ref]

The number of total renal events in preterm infants within 30 days of therapy following IV use was 21% and included increased blood urea (7%), renal insufficiency/impairment (6%), reduced urine output (3%), increased blood creatinine (3%), renal failure (1%), and increased blood urea with hematuria (1%).^[Ref]

Hematologic

• Very common (10% or more): Anemia (up to 36%), eosinophilia (up to 26%), neutropenia (up to 13%), thrombocythemia (up to 10%)
• Common (1% to 10%): Hemoglobin decreased
• Very rare (less than 0.01%): Leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, pancytopenia, hematocrit decreased
• Frequency not reported: lymphadenopathy, bleeding episodes

Patent Ductus Arteriosus:

• Very common (10% or more): Anemia (32%), total bleeding (32%), intraventricular hemorrhage (29%), Neutropenia, thrombocytopenia^[Ref]

The incidence of total bleeding events within 30 days of therapy with IV use in preterm infants was 32%. This percentage included grade 1 and 2 intraventricular hemorrhage (15%), grade 3 and 4 intraventricular hemorrhage (15%), and other bleeding (6%).^[Ref]

Dermatologic

• Common (1% to 10%): Rash, maculopapular rash, pruritus
• Very rare (less than 0.01%): Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis
• Frequency not reported: Ecchymosis, purpura, alopecia, sweating, photosensitivity, angioedema, exfoliative dermatitis, urticaria, vesiculobullous eruptions, Henoch Schonlein vasculitis

Patent Ductus Arteriosus:

• Very common (10% or more): Skin lesion/irritation (16%)^[Ref]

Metabolic

• Very common (10% or more): Hypokalemia (up to 19%), hypoproteinemia (up to 13%), blood urea increased (10%), hypernatremia (10%), hypoalbuminemia (10%)
• Common (1% to 10%): Appetite decreased, fluid retention
• Frequency not reported: Appetite changes, hyperglycemia, hypoglycemic reaction, acidosis

Patent Ductus Arteriosus:

• Very common (10% or more): Hypoglycemia (12%), hypocalcemia (12%), blood creatinine increased, blood sodium decreased
• Common (1% to 10%): Hypernatremia
• Frequency not reported: Feeding problems, hyperglycemia^[Ref]

Other

• Very common (10% or more): Bacteremia (13%), blood LDH increased (up to 10%)
• Common (1% to 10%): Peripheral edema, wound hemorrhage, tinnitus, hearing impairment, edema, fatigue
• Very rare (less than 0.01%): Aseptic meningitis, vertigo, exacerbation of infection-related inflammations
• Frequency not reported: Fever, infection, sepsis, weight changes, asthenia, malaise, pseudo-tumor, hearing loss, drowsiness

Patent Ductus Arteriosus:

• Very common (10% or more): Sepsis (43%)
• Common (1% to 10%): Edema, fluid retention
• Frequency not reported: Various infections^[Ref]

Respiratory

• Very common (10% or more): Bacterial pneumonia (up to 10%)
• Common (1% to 10%): Cough
• Very rare (less than 0.01%): Asthma, bronchospasm, dyspnea, wheezing
• Frequency not reported: Apnea, respiratory depression, pneumonia, rhinitis, epistaxis

Patent Ductus Arteriosus:

• Very common (10% or more): Apnea (28%), respiratory infection (19%), respiratory failure (10%), bronchopulmonary dysplasia
• Common (1% to 10%): Atelectasis, pulmonary hemorrhage
• Uncommon (0.1% to 1%): Hypoxemia
• Postmarketing reports: Pulmonary hypertension^[Ref]

Hepatic

• Very rare (less than 0.01%): Hepatitis, jaundice
• Frequency not reported: Hepatorenal syndrome, liver necrosis, liver failure, abnormal liver function tests

Patent Ductus Arteriosus:

• Frequency not reported: Cholestasis, jaundice^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylactoid reactions, hypersensitivity reaction^[Ref]

Hypersensitivity reactions have been reported and may consist of any of the following: a syndrome of abdominal pain, fever, chills, nausea, vomiting, and anaphylaxis; respiratory tract reactivity comprising bronchospasm, asthma/aggravated asthma, or dyspnea; skin reactions, which rarely included exfoliative and bullous dermatoses, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, pruritus, and urticaria.^[Ref]

Ocular

• Very rare (less than 0.01%): Visual disturbances
• Frequency not reported: Blurred vision, amblyopia, diminished vision, scotomata, changes in color vision, conjunctivitis, dry eyes, diplopia, optic neuritis, cataracts, optic neuritis, toxic optic neuropathy^[Ref]

Musculoskeletal

• Frequency not reported: Lupus erythematosus syndrome^[Ref]

Psychiatric

• Frequency not reported: Anxiety, confusion, depression, dream abnormalities, insomnia, emotional lability, hallucinations^[Ref]

Genitourinary

• Common (1% to 10%): Urinary retention
• Very rare (less than 0.01%): Proteinuria, hematuria
• Frequency not reported: Dysuria, oliguria, polyuria, menorrhagia

Patent Ductus Arteriosus:

• Very common (10% or more): Oliguria, hematuria
• Common (1% to 10%): Urinary tract infection^[Ref]

Immunologic

• Frequency not reported: Serum sickness^[Ref]

Local

• Common (1% to 10%): Infusion site pain
• Postmarketing reports: Transient sensation of burning in mouth/throat

Patent Ductus Arteriosus:

• Frequency not reported: Injection site reactions^[Ref]

Endocrine

• Frequency not reported: Gynecomastia

Patent Ductus Arteriosus:

• Common (1% to 10%): Adrenal insufficiency^[Ref]

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Further information

Midol IB side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer