Meningococcal polysaccharide vaccine Side Effects
For the Consumer
Applies to meningococcal polysaccharide vaccine: parenteral for injection for sub-q use, parenteral solution for im use
Side effects include:
MCV4 (Menactra®): Injection site reactions (e.g., pain, induration, erythema, swelling), headache, fatigue, malaise, arthralgia, diarrhea, anorexia, chills, fever, vomiting, rash.
MCV4 (Menveo®): Injection site reactions (pain, erythema, induration), irritability, sleepiness, malaise, headache in children 2 through 10 years of age; injection site pain, headache, myalgia, malaise, nausea in adults and adolescents.
MPSV4 (Menomune®): Injection site reactions (e.g., pain, erythema, induration, swelling), headache, malaise, chills, fever.
Hib-MenCY (MenHibrix®): Injection site reactions (e.g., pain, redness, swelling), systemic effects (e.g., fever, irritability, drowsiness, loss of appetite).
For Healthcare Professionals
Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection
The most common adverse events were injection site pain, headache, irritability, and diarrhea.[Ref]
Very common (10% or more): Injection site pain (48.1%), injection site redness (16%), injection site induration (11%), injection site tenderness
Common (1% to 10%): Injection site swelling, injection site hematoma
Uncommon (0.1% to 1%): Injection site reaction
Rare (less than 0.1%): Severe local reactions
Postmarketing reports: Extensive limb swelling at the injection site (frequently associated with erythema, sometimes involving the adjacent joint or swelling of the entire injected limb)[Ref]
Very common (10% or more): Headache (41.8%), drowsiness (11.2%)
Uncommon (0.1% to 1%): Hypoesthesia, dizziness
Very rare (less than 0.01%): Somnolence, neurological reactions
Postmarketing reports: Vasovagal syncope, paresthesia, Guillain-Barre syndrome[Ref]
Very common (10% or more): Fatigue (32.3%), malaise (22.3%), fever
Common (1% to 10%): Chills, febrile reactions (>38C)
Postmarketing reports: Asthenia, influenza-like symptoms[Ref]
Very common (10% or more): Irritability (12.2%)
Uncommon (0.1% to 1%): Insomnia, crying[Ref]
Very common (10% or more): Arthralgia (16%)
Uncommon (0.1% to 1%): Myalgia, pain in extremity
Postmarketing reports: Musculoskeletal stiffness[Ref]
Very common (10% or more): Appetite lost
Common (1% to 10%): Anorexia
Postmarketing reports: Decreased appetite[Ref]
Very common (10% or more): Diarrhea (14%)
Common (1% to 10%): Vomiting, nausea[Ref]
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus
Rare (less than 0.1%): Urticaria, angioedema
Postmarketing reports: Angioneurotic edema[Ref]
Very common (10% or more): Local axillary lymphadenopathy[Ref]
Postmarketing reports: Hypersensitivity (such as rash, urticaria, pruritus, dyspnea, angioedema), allergic reactions (including anaphylactic and anaphylactoid reactions)[Ref]
Uncommon (0.1% to 1%): Upper respiratory tract illness
Rare (less than 0.1%): Wheeze[Ref]
Postmarketing reports: IgA nephropathy[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Menomune (meningococcal polysaccharide vaccine)." Sanofi Pasteur, Toronto, IA.
Not all side effects for meningococcal polysaccharide vaccine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about meningococcal polysaccharide vaccine
- Other brands: Menomune A/C/Y/W-135
- Meningococcal Vaccine (AHFS Monograph)
- Meningococcal Polysaccharide Vaccine (Groups A / C / Y and W-135) (Wolters Kluwer)
Related treatment guides
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