Medication Guide App

Meningococcal polysaccharide vaccine Side Effects

Not all side effects for meningococcal polysaccharide vaccine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to meningococcal polysaccharide vaccine: subcutaneous injectable, subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by meningococcal polysaccharide vaccine. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking meningococcal polysaccharide vaccine:

Symptoms of allergic reaction
  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some of the side effects that can occur with meningococcal polysaccharide vaccine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Redness at place of injection—may last 1 or 2 days
  • tenderness, soreness, or pain at place of injection
Less common
  • Chills
  • fever over 100 °F (37.8 °C)
  • general feeling of discomfort or illness
  • hard lump at place of injection
  • headache
  • tiredness or weakness

For Healthcare Professionals

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection


General side effects have included headache malaise, chills and fever.[Ref]


Local side effects have included pain, tenderness, erythema and induration at the injection site.[Ref]


1. "Product Information. Menomune-A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught, Swiftwater, PA.

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