Meningococcal polysaccharide vaccine Side Effects

It is possible that some side effects of meningococcal polysaccharide vaccine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to meningococcal polysaccharide vaccine: subcutaneous injectable, subcutaneous powder for solution

Along with its needed effects, meningococcal polysaccharide vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking meningococcal polysaccharide vaccine:

Symptoms of allergic reaction
  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects of meningococcal polysaccharide vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Redness at place of injection—may last 1 or 2 days
  • tenderness, soreness, or pain at place of injection
Less common
  • Chills
  • fever over 100 °F (37.8 °C)
  • general feeling of discomfort or illness
  • hard lump at place of injection
  • headache
  • tiredness or weakness

For Healthcare Professionals

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection


General side effects have included headache malaise, chills and fever.


Local side effects have included pain, tenderness, erythema and induration at the injection site.

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