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Loxitane Side Effects

Generic Name: loxapine

Note: This page contains information about the side effects of loxapine. Some of the dosage forms included on this document may not apply to the brand name Loxitane.

Not all side effects for Loxitane may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to loxapine: oral capsule, oral solution, oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by loxapine (the active ingredient contained in Loxitane). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking loxapine:

More common
  • Difficulty with speaking or swallowing
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • puffing of the cheeks
  • rapid or fine, worm-like movements of the tongue
  • restlessness or desire to keep moving
  • shuffling walk
  • slowed movements
  • stiffness of the arms and legs
  • trembling and shaking of the fingers and hands
  • uncontrolled chewing movements
  • uncontrolled movements of the arms or legs
Less common
  • Constipation (severe)
  • difficult urination
  • inability to move the eyes
  • muscle spasms, especially of the neck and back
  • skin rash
  • twisting movements of the body
  • Convulsions (seizures)
  • difficult or fast breathing
  • fast heartbeat or irregular pulse
  • fever (high)
  • high or low blood pressure
  • increased blinking or spasms of the eyelid
  • increased sweating
  • loss of bladder control
  • muscle stiffness (severe)
  • sore throat and fever
  • uncontrolled twisting movements of neck, trunk, arms, or legs
  • unusual bleeding or bruising
  • unusual facial expressions or body positions
  • unusual tiredness or weakness
  • unusually pale skin
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking loxapine, get emergency help immediately:

Symptoms of overdose
  • Dizziness (severe)
  • drowsiness (severe)
  • muscle trembling, jerking, stiffness, or uncontrolled movements (severe)
  • troubled breathing (severe)
  • unusual tiredness or weakness (severe)

Some of the side effects that can occur with loxapine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Blurred vision
  • confusion
  • dizziness, lightheadedness, or fainting
  • drowsiness
  • dryness of the mouth
Less common
  • Constipation (mild)
  • decreased sexual ability
  • enlargement of breasts (males and females)
  • headache
  • increased sensitivity of the skin to sun
  • missing menstrual periods
  • nausea or vomiting
  • trouble with sleeping
  • unusual secretion of milk
  • weight gain

For Healthcare Professionals

Applies to loxapine: inhalation powder, intramuscular solution, oral capsule, oral concentrate

Nervous system

Nervous system side effects including Neuroleptic malignant syndrome (NMS), agitation, drowsiness, dizziness, faintness, staggering gait, tremor, shuffling gait, muscle twitching, weakness, insomnia, tension, rigidity, excessive salivation, akathisia, muscle spasms in neck and face, tongue protrusion, seizures, akinesia, paresthesia, slurred speech, numbness, and confusion have been frequently reported.[Ref]


Cardiovascular side effects including tachycardia, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, and syncope have been reported.[Ref]


Gastrointestinal side effects including nausea, vomiting, and constipation have been reported.[Ref]


Hematologic side effects including agranulocytosis, thrombocytopenia, and leukopenia have rarely been reported.[Ref]


Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity have been reported.[Ref]


Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.[Ref]


Hepatic side effects including hepatocellular injury, increased SGOT/SGPT levels, jaundice, and hepatitis have rarely been reported.[Ref]


Dermatologic side effects including dermatitis, edema, pruritus, rash, alopecia, and seborrhea have been reported.[Ref]


Respiratory side effects including dyspnea have been infrequently reported.[Ref]


General side effects including dry mouth, weight gain, weight loss, headache, hyperpyrexia, and polydipsia have been reported.[Ref]


1. "Product Information. Loxitane C Oral Concentrate (loxapine)" Watson Laboratories Inc, Corona, CA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.