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Lipitor Side Effects

Generic name: atorvastatin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 4, 2023.

Note: This document provides detailed information about Lipitor Side Effects associated with atorvastatin. Some dosage forms listed on this page may not apply specifically to the brand name Lipitor.

Applies to atorvastatin: oral suspension, oral tablet.

Common side effects of Lipitor

Some side effects of atorvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • headache
  • hoarseness
  • lower back or side pain
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • stuffy or runny nose

Less common

  • back pain
  • belching or excessive gas
  • constipation
  • general feeling of discomfort or illness
  • heartburn, indigestion, or stomach discomfort
  • lack or loss of strength
  • loss of appetite
  • nausea
  • shivering
  • stomach pain
  • sweating
  • trouble sleeping
  • vomiting

Incidence not known

  • appetite increased
  • black, tarry stools
  • bloody nose
  • bloody or cloudy urine
  • blurred vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficult, burning, or painful urination
  • difficulty seeing at night
  • excessive muscle tone or tension
  • fruit-like breath odor
  • groin or scrotum pain
  • inability to have or keep an erection
  • increased body movements
  • increased sensitivity of the eyes to light
  • increased sensitivity to touch or pain
  • increased thirst
  • increased urination
  • loss of bladder control
  • loss of sexual ability, drive, or desire
  • menstrual bleeding occurring earlier or lasting longer than usual
  • mental depression
  • nervousness
  • nightmares
  • pale skin
  • paranoia
  • pinpoint red spots on the skin
  • slurred speech
  • swollen or tender lymph glands in the neck, armpit, or groin
  • unable to move or feel face
  • unusual bleeding or bruising
  • weight loss

Serious side effects of Lipitor

Along with its needed effects, atorvastatin (the active ingredient contained in Lipitor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atorvastatin:

Less common or rare

  • chest tightness
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives, itching, skin rash
  • muscle cramps, pain, stiffness, swelling, or weakness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness

Incidence not known

  • blistering, peeling, or loosening of the skin
  • chills
  • dark-colored urine
  • diarrhea
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • red skin lesions, often with a purple center sore
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips

For healthcare professionals

Applies to atorvastatin: oral suspension, oral tablet.

General

The most common adverse reactions were nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract infection.[Ref]

Dermatologic

Bullous rashes/bullous dermatitis included erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis.

Endocrine

Gastrointestinal

Genitourinary

Hematologic

Hepatic

Persistent elevations in serum transaminases, defined as greater than 3 times the upper limit of normal (3 x ULN) and occurring on at least 2 occasions, occurred in 0.7% of patients who received this drug in clinical trials; these occurred in 0.2%, 0.2%, 0.6%, and 2.3% of patients taking 10, 20, 40, and 80 mg, respectively.

Abnormal liver function test included increased hepatic enzyme, increased ALT, increased AST, increased blood bilirubin, abnormal liver function test, and increased transaminases.

Hypersensitivity

Hypersensitivity included anaphylaxis.

Metabolic

Musculoskeletal

Statins:

Elevated CPK (at least 10 x ULN) was higher in the high-dose group (80 mg: 0.3%) compared to the low-dose group (10 mg: 0.1%).

Signs/symptoms of rhabdomyolysis included muscle weakness, muscle swelling, muscle pain, dark urine, myoglobinuria, elevated serum creatine kinase, acute renal failure, and cardiac arrhythmia.

Immune-mediated necrotizing myopathy has been reported rarely with statin use; there have been reports of recurrence when the same or a different statin was administered.

Nervous system

Statins:

Hemorrhagic stroke was reported in 2.3% of patients. The incidence of fatal hemorrhagic stroke was similar between this drug and placebo, while the incidence of nonfatal hemorrhagic stroke was significantly greater with this drug.

Cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) has been reported rarely with all statins. Cognitive impairment was generally nonserious and reversible upon statin discontinuation; times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks) were variable.

New-onset or exacerbation of myasthenia gravis (including ocular myasthenia) has been reported rarely with statin use; there have been reports of recurrence when the same or a different statin was administered.

Ocular

Statins:

Other

Psychiatric

Renal

Acute kidney injury secondary to myoglobinuria and rare fatalities have occurred as a result of rhabdomyolysis in patients treated with this drug.

Respiratory

Exceptional cases of interstitial lung disease (especially with long-term therapy) have been reported with some statins.

References

1. (2024) "Product Information. Lipitor (atorvastatin)." Viatris Specialty LLC, SUPPL-81

2. (2024) "Product Information. Atorvaliq (atorvastatin)." Carolina Medical Products Company, SUPPL-2

3. (2023) "Product Information. Lipitor (atorvastatin)." Aspen Pharmacare Australia Pty Ltd

4. (2024) "Product Information. Lorstat (atorvastatin)." Alphapharm Pty Ltd

5. (2024) "Product Information. Lipitor (atorvastatin)." Viatris UK Healthcare Ltd

6. (2024) "Product Information. Atorvastatin (atorvastatin)." Rosemont Pharmaceuticals Ltd

Frequently asked questions

Further information

Lipitor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.