Letairis Side Effects

Generic Name: ambrisentan

Please note - some side effects for Letairis may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Letairis - for the Consumer

Letairis

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Letairis:

Constipation; flushing; nose or throat irritation; stomach pain or upset; stuffy nose.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fever; fluid retention; irregular heartbeat; loss of appetite; nausea; pale stools; severe or persistent stomach pain; shortness of breath; sudden weight gain; swelling (eg, of the arms, legs, hands, feet); unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

Letairis Side Effects - for the Professional

Letairis

• Most common placebo-adjusted adverse reactions are peripheral edema, nasal congestion, sinusitis, flushing, palpitations, abdominal pain, and constipation (6.1).
• Fluid retention was identified as an adverse reaction during postapproval use of Letairis (6.2).

Side Effects by Body System

Hepatic

Hepatic side effects have included dose-dependent liver injury manifested primarily by elevation of serum aminotransferases (ALT or AST), but sometimes accompanied by abnormal liver function (elevated bilirubin). The combination of aminotransferases greater than 3-times the upper limit of normal and total bilirubin 2 times the upper limit of normal is a marker for potentially serious hepatic injury.

Hematologic

Hematologic side effects have included decreases in hemoglobin concentration and hematocrit.

Cardiovascular

Cardiovascular side effects have included peripheral edema, palpitations, and flushing. Fluid retention has been reported during postmarketing use of ambrisentan.

Respiratory

Respiratory side effects have included dyspnea, nasal congestion, sinusitis, and nasopharyngitis.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain and constipation.

Nervous system

Nervous system side effects have included headache.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.