Lanthanum carbonate Side Effects

Not all side effects for lanthanum carbonate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lanthanum carbonate: oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by lanthanum carbonate. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lanthanum carbonate:

More common
  • Dialysis graft blockage
Incidence not known
  • Bone pain
  • convulsions
  • difficulty having a bowel movement (stool)
  • itching skin
  • loss of appetite
  • skin rash
  • trouble breathing
  • unusual tiredness or weakness

Some of the side effects that can occur with lanthanum carbonate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • nausea
  • runny nose
  • sneezing
  • stomach pain
  • stuffy nose
  • vomiting
Incidence not known
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort or upset
  • tooth injury

For Healthcare Professionals

Applies to lanthanum carbonate: oral tablet chewable


Gastrointestinal side effects (including nausea, vomiting, and diarrhea) were the most prominent reasons for discontinuation of therapy in clinical studies.

One study reported incidence of nausea and vomiting as high as 16% and 18%, respectively.[Ref]

Gastrointestinal side effects have frequently included nausea (11%, compared to 5% with placebo), vomiting (9%, compared to 4% with placebo), abdominal pain (5%, compared to 0% with placebo), diarrhea (13% to 23%), and constipation (6% to 14%). Postmarketing gastrointestinal side effects have included dyspepsia.[Ref]


Cardiovascular side effects have included hypotension (8% to 16%).[Ref]


Respiratory side effects have included bronchitis (5%) and rhinitis (5% to 7%).[Ref]


Other side effects have included dialysis graft complication (3% to 26%), headache (5% to 21%), and dialysis graft occlusion (4% to 21%). Other side effects reported postmarketing have included tooth injury.[Ref]


Metabolic side effects have included hypercalcemia (up to 4%). Metabolic side effects reported postmarketing have included hypophosphatemia and hypocalcemia (up to 5%).[Ref]


Dermatologic side effects reported postmarketing have included allergic skin reactions.


1. Hutchison AJ, Maes B, Vanwalleghem J, et al. "Efficacy, Tolerability, and Safety of Lanthanum Carbonate in Hyperphosphatemia: A 6-Month, Randomized, Comparative Trial versus Calcium Carbonate." Nephron Clin Pract 100 (2005): c8-c19

2. "Product Information. Fosrenol (lanthanum carbonate)." Shire US Inc, Florence, KY.

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