Generic Name: sevelamer (se VEL a mer)
Brand Names: Renagel, Renvela

What is Renvela?

Renvela (sevelamer) is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.

Renvela is used to control phosphorus levels in people with chronic kidney disease who are on dialysis.

Renvela may also be used for purposes not listed in this medication guide.

Important information

You should not take Renvela if you are allergic to sevelamer, or if you have a bowel obstruction.

Before taking Renvela, tell your doctor if you have severe constipation, a blockage in your intestines, a stomach or intestinal disorder, trouble swallowing, or if you have recently had stomach or intestinal surgery.

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Avoid taking any other medicines within 1 hour before or 3 hours after you take Renvela. Sevelamer can bind to other medications and make them less effective.

Before taking Renvela, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.

Before taking this medicine

You should not take Renvela if you are allergic to sevelamer, or if you have a bowel obstruction.

To make sure you can safely take Renvela, tell your doctor if you have any of these other conditions:

  • trouble swallowing;

  • severe constipation;

  • a blockage in your intestines;

  • a stomach or intestinal disorder; or

  • if you have recently had stomach or intestinal surgery.

FDA pregnancy category C. It is not known whether Renvela will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether sevelamer passes into breast milk or if it could harm a nursing baby. Do not use Renvela without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Renvela?

Take Renvela exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take Renvela with meals. Do not crush, chew, or break the Renvela tablet. Swallow the pill whole. Renvela tablets expand when they are wet, and breaking or crushing the pill may make it harder to swallow.

Renvela powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water.

Stir the Renvela powder in water until it is completely dissolved. Drink all of this mixture right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

To be sure Renvela is helping your condition and not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Renvela may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition.

Store Renvela at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Avoid taking any other medicines within 1 hour before or 3 hours after you take Renvela. Sevelamer can bind to other medications and make them less effective.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.

Renvela side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Renvela: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Renvela and call your doctor at once if you have a serious side effect such as:

  • black, bloody, or tarry stools;

  • constipation that gets worse or does not clear up;

  • severe constipation with stomach pain; or

  • fever, chills, body aches, flu symptoms.

Less serious Renvela side effects may include:

  • nausea, vomiting, stomach pain, loss of appetite;

  • upset stomach, gas, bloating;

  • diarrhea, mild constipation;

  • tired feeling;

  • itching; or

  • joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Renvela?

Tell your doctor about all other medicines you use, especially:

  • ciprofloxacin (Cipro);

  • levothyroxine (Synthroid, Levothroid, Levoxyl);

  • a heart rhythm medication; or

  • a seizure medication.

This list is not complete and other drugs may interact with Renvela. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Renvela.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Renvela only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 9.02. Revision Date: 2012-07-27, 10:08:48 AM.

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