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Ioversol Side Effects

Not all side effects for ioversol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ioversol: injection solution

In addition to its needed effects, some unwanted effects may be caused by ioversol. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ioversol, check with your doctor or nurse immediately:

Less common or rare
  • Arm, back, or jaw pain
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • coughing
  • coughing that sometimes produces a pink frothy sputum
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult, fast, noisy breathing, sometimes with wheezing
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • feeling of constant movement of self or surroundings
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • increased sweating
  • nausea
  • nervousness
  • painful urination
  • pale skin
  • pounding in the ears
  • redness of the skin
  • sensation of spinning
  • severe numbness, especially on one side of the face or body
  • severe, unusual tiredness or weakness
  • slow, fast, or irregular heartbeat
  • slow or irregular breathing
  • sweating
  • swelling around the eyes
  • swelling in the legs and ankles
  • unusual tiredness or weakness
  • Blood in the stools or urine
  • bruising
  • changes in skin color
  • coughing or vomiting blood
  • pains in the chest, groin, or legs, especially calves of the legs
  • pain, tenderness, or swelling of the foot or leg
  • persistent bleeding or oozing from puncture sites, mouth, or nose
  • severe headaches of sudden onset
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
Incidence not known
  • Extremely high fever or body temperature
  • fast, shallow breathing
  • fast, weak heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle cramps
  • no sensation in the legs
  • not able to pass urine
  • pale, clammy skin
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • thirst
  • unable to move the legs

Some of the side effects that can occur with ioversol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare
  • Bad taste
  • collection of blood under the skin
  • deep, dark purple bruise
  • dry mouth
  • pain, redness, or pale skin at the injection site
  • vomiting

For Healthcare Professionals

Applies to ioversol: injectable solution


Regardless of the contrast medium employed, the overall incidence of serious adverse reaction is higher with coronary arteriography than with other procedures. Cardiac decompensation, serious arrhythmias, myocardial ischemia, or myocardial infarction may occur during coronary arteriography and left ventriculography.[Ref]

Cardiovascular side effects including angina pectoris, hypotension, blood pressure fluctuation, arterial spasm, bradycardia, conduction defect, false aneurysm, hypertension, transient arrhythmia, and vascular trauma have been reported in patients receiving ioversol. Serious, life-threatening, and fatal reactions, angioneurotic edema, peripheral edema, vasodilation, thrombosis, and rarely thrombophlebitis, disseminated intravascular coagulation, and shock have been associated with the administration of iodine-containing contrast media.[Ref]


Respiratory side effects including laryngeal edema, pulmonary edema, sneezing, congestion, coughing, shortness of breath, and hypoxia have been reported. Choking, dyspnea, wheezing (which may be an initial manifestation of more severe and infrequent reactions including asthmatic attack), laryngospasm, bronchospasm, apnea, and cyanosis have been reported with the use of other contrast agents and are possible with any water soluble, iodinated contrast agent.[Ref]


Gastrointestinal side effects including nausea, vomiting, and dry mouth have been reported.[Ref]

Nervous system

Nervous system side effects including headache, cerebral infarct, vertigo, lightheadedness, visual hallucination, vasovagal reaction disorientation, paresthesia, dysphasia, muscle spasm, and syncope have been reported with the use of ioversol. Convulsions, aphasia, paralysis, coma, and death have been reported with the use of other contrast agents and are possible with any water soluble, iodinated contrast agent.[Ref]


Ocular side effects including blurred vision have been reported with the use of ioversol. Visual field losses which are usually transient but may be permanent have been reported with the use of other contrast agents and are possible with any water soluble, iodinated contrast agent.


Dermatologic side effects including periorbital edema, urticaria, pruritus, facial edema, flush, and erythema have been reported. Maculopapular rash, erythema, conjunctival symptoms, ecchymosis, and tissue necrosis have been reported with the use of other contrast agents and are possible with any water soluble, iodinated contrast agent.[Ref]


Local side effects including extravasation have been reported.[Ref]


Hematologic side effects including hematoma have been reported.[Ref]


General side effects including shaking chills, general pain, and fever have been reported with the use of ioversol. Hyperthermia has been reported with the use of other contrast agents and is possible with any water soluble, iodinated contrast agent.[Ref]


Other side effects including bad taste have been reported.[Ref]


Renal side effects including renal colic, urinary retention, and polyuria have been reported with the use of ioversol. Temporary anuria and other nephropathies have been reported with the use of other contrast agents and are possible with any water soluble, iodinated contrast agent.[Ref]


1. "Product Information. Optiray 350 (ioversol)." Mallinckrodt Medical Inc, St. Louis, MO.

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