Interferon gamma-1b Side Effects

Brand Names: Actimmune

Please note - some side effects for Interferon gamma-1b may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Interferon gamma-1b - for the Consumer

Interferon Gamma-1B

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Interferon Gamma-1B:

Diarrhea; fatigue; flu-like symptoms (eg, low-grade fever, chills, general body discomfort); headache; joint pain; muscle pain; nausea; pain, redness, or swelling at the injection site; tiredness; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; dizziness; fainting; fast or irregular heartbeat; high or persistent fever; mood or mental changes; seizures; signs of infection (eg, chills, persistent sore throat); stomach pain; trouble walking; unusual bruising or bleeding; yellowing of the eyes or skin.

Side Effects by Body System

General

General flu-like side effects have been reported most frequently. These have included fever (52%), headache (33%), chills (14%), fatigue (14%), myalgia (6%), and arthralgia (2%). Chest discomfort has been reported.

Gastrointestinal

Gastrointestinal side effects have been reported frequently. These have included diarrhea (14%), vomiting (13%), and nausea (10%). Gastrointestinal bleeding has been reported rarely.

Dermatologic

Dermatologic side effects have included rash (17%).

Local

Local side effects have included erythema or tenderness at the site of injection (14%).

Cardiovascular

Cardiovascular side effects have been reported rarely. These have included hypotension, syncope, tachyarrhythmia, heart block, heart failure, and myocardial infarction.

Nervous system

Nervous system side effects have been reported rarely. These have included confusion, disorientation, gait disturbance, Parkinsonian symptoms, seizure, hallucinations, and transient ischemic attacks.

Respiratory

Respiratory side effects have included tachypnea, bronchospasm, and interstitial pneumonitis.

Hematologic

Hematologic side effects have been reported rarely. These have included deep venous thrombosis and pulmonary embolism.

Renal

Renal side effects have included renal insufficiency which was reversible.

Metabolic

Metabolic side effects have included hyponatremia, hyperglycemia, and hypertriglyceridemia.

Immunologic

Immunologic side effects have included increased autoantibodies and lupus-like syndrome.

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