Interferon Gamma-1B Dosage

This dosage information may not include all the information needed to use Interferon Gamma-1B safely and effectively. See additional information for Interferon Gamma-1B.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Osteopetrosis

BSA: greater than 0.5 m2
50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2
1.5 mcg/kg/dose subcutaneously three times weekly.

Usual Adult Dose for Chronic Granulomatous Disease

BSA: greater than 0.5 m2
50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2
1.5 mcg/kg/dose subcutaneously three times weekly.

Usual Adult Dose for Idiopathic Pulmonary Fibrosis

Study (n = 9)
200 mcg subcutaneously three times weekly (in combination with prednisolone 7.5 mg/day) for 12 months.

Usual Adult Dose for Cutaneous T-cell Lymphoma

Case study (Granulomatous slack skin)
2,000,000 units IV daily for 14 days.

Usual Pediatric Dose for Chronic Granulomatous Disease

Greater than or equal to 1 year old:

BSA: greater than 0.5 m2
50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2
1.5 mcg/kg/dose subcutaneously three times weekly

Less than 1 year old: no data available

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Decrease dose by 50% if severe reactions occur or discontinue therapy until adverse reaction abates.

Precautions

Acute and transient flu-like symptoms such as fever and chills that are frequently associated with interferon gamma-1b therapy may exacerbate pre-existing cardiac conditions. Interferon gamma-1b should be administered with caution to patients with preexisting cardiac conditions including ischemia, congestive heart failure, or arrhythmia.

Interferon gamma-1b should be administered with caution in patients with known seizure disorders and/or compromised central nervous system function due to potential exacerbation of adverse effects including decreased mental status, gait disturbance, and dizziness.

Reversible neutropenia and thrombocytopenia that can be severe and may be dose related have been observed during interferon gamma-1b therapy. Caution should be exercised when administering interferon gamma-1b to immunosuppressed patients.

Patients should have laboratory tests including complete blood counts, differential counts, platelet counts, urinalysis, renal function test, and liver function test prior to, and at three-month intervals, during interferon gamma-1b treatment.

Isolated cases of acute serious hypersensitivity reactions have been reported in patients receiving interferon gamma-1b. If such an acute adverse event develops, the drug should be discontinued immediately and appropriate medical therapy instituted. Transient cutaneous rashes have been reported in some patients following injection but have rarely necessitated treatment interruption.

Elevations of AST and/or ALT (up to 25-fold) have been reported during interferon gamma-1b therapy. The incidence appeared to be higher in patients less than 1 year of age compared to older children. The transaminases elevations were reversible with reduction in dosage or interruption of interferon gamma-1b therapy. Patients started on interferon gamma-1b before age one year should receive monthly assessments of liver function. Interferon gamma-1b dosage should be modified if severe hepatic enzyme elevations develop.

Dialysis

Data not available

Other Comments

Each 0.5 mL of Actimmune contains 100 mcg (2 million intl units) of interferon gamma-1b. The current 1 million intl units/50 mcg is equivalent to the former expression as units (1.5 million units/50 mcg).

The best sites for the subcutaneous injection are the right and left deltoid and the anterior thigh.

Bedtime administration and pretreatment with analgesics/antipyretics may ameliorate the influenza-like symptoms on treatment days.

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