Imbruvica Side Effects
Generic Name: ibrutinib
Note: This document contains side effect information about ibrutinib. Some of the dosage forms listed on this page may not apply to the brand name Imbruvica.
Some side effects of Imbruvica may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ibrutinib: oral capsule
Get emergency medical help if you have any of these signs of an allergic reaction while taking ibrutinib (the active ingredient contained in Imbruvica) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using ibrutinib and call your doctor at once if you have:
severe or ongoing diarrhea;
severe weakness or dizziness, confusion, problems with speech, prolonged headache;
easy bruising or bleeding (nosebleeds, bleeding gums);
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
red or pink urine;
confusion, loss of appetite, vomiting, pain in your side or lower back;
little or no urinating, swelling, rapid weight gain;
fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating.
Common side effects may include:
nausea, stomach pain, diarrhea, constipation, loss of appetite;
muscle or joint pain;
swelling in your hands or feet; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to ibrutinib: oral capsule
The most commonly occurring adverse reactions were thrombocytopenia, diarrhea, neutropenia, anemia, fatigue, musculoskeletal pain, peripheral edema, upper respiratory tract infection, nausea, bruising, dyspnea, constipation, rash, abdominal pain, vomiting and decreased appetite.
Very common (10% or more): Bruising (30%), rash (25%), skin infections (14%), petechiae (11%)
Very common (10% or more): Diarrhea (51%), nausea (31%), constipation (25%), abdominal pain (24%), vomiting (23%), stomatitis (17%), dyspepsia (11%)
Very common (10% or more): Decreased platelets (57%), decreased neutrophils (47%), decreased hemoglobin (41%),
Common (1% to 10%): Subdural hematoma (1.8%)
Very common (10% or more): Decreased appetite (21%), hyperuricemia (15%), dehydration (12%)
Very common (10% or more): Musculoskeletal pain (37%), muscle spasms (14%), arthralgia (11%)
Very common (10% or more): Dizziness (14%), headache (13%)
Very common (10% or more): Fatigue (41%), peripheral edema (35%), pyrexia (18%), asthenia (14%)
Very common (10% or more): Upper respiratory tract infection (34%), dyspnea (27%), cough (19%), epistaxis (11%), pneumonia 14%), sinusitis (13%)
More about Imbruvica (ibrutinib)
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