Iloprost Side Effects

Some side effects of iloprost may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to iloprost: inhalation solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking iloprost: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• feeling like you might pass out;

• pounding heartbeats or fluttering in your chest;

• coughing up blood;

• unusual bleeding (nosebleeds, bleeding gums);

• fever, chills, cough with yellow or green mucus;

• chest tightness, stabbing chest pain, wheezing, feeling short of breath; or

• anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.

Less serious side effects of iloprost may include:

• flushing (warmth, redness, or tingly feeling);

• increased cough;

• nausea, vomiting, diarrhea;

• headache, dizziness;

• muscle cramps, back pain;

• sleep problems (insomnia);

• tongue pain, jaw tightness or pain, trouble chewing or speaking; or

• altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to iloprost: inhalation solution

Cardiovascular

Cardiovascular side effects have included congestive heart failure, chest pain, supraventricular tachycardia, peripheral edema, vasodilation (flushing), hypotension, palpitations and syncope.

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting. Postmarketing experience has included diarrhea.

Hepatic

Hepatic side effects have included increased GGT (gamma-glutamyltranspeptidase) and alkaline phosphatase levels.

Musculoskeletal

Musculoskeletal side effects have included muscle cramps, back pain, tongue pain and trismus.

Nervous system

Nervous system side effects have included headache, dizziness and insomnia.

Renal

Renal side effects have included kidney failure.

Respiratory

Respiratory side effects have included hemoptysis, pneumonia, dyspnea and increased cough. Postmarketing experience has included cases of bronchospasm and wheezing, particularly in susceptible patients with hyperreactive airways.

General

General side effects have included flu syndrome. Postmarketing reports have included mouth and tongue irritation and dysgeusia.

Other

Other side effects have included cases of epistaxis and gingival bleeding which have been reported within one month of starting iloprost treatment.

Hypersensitivity

Hypersensitivity side effects have included postmarketing reports of hypersensitivity and rash.

Dermatologic

Dermatologic side effects have included postmarketing reports of rash.

Hematologic

Hematologic side effects have included postmarketing reports of thrombocytopenia.

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