Iloprost Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pulmonary Hypertension

Iloprost is intended for inhalation administration via either of two pulmonary drug delivery devices: the Prodose AAD System or the I-neb AAD System. It has not been studied with any other nebulizers. The first inhaled dose should be 2.5 mcg. If this dose is well tolerated, dosing should be increased to 5 mcg and maintained at that dose. Iloprost should be taken 6 to 9 times per day (no more than every 2 hours) during walking hours, according to individual need and tolerability. The maximum daily dose evaluated in clinical studies was 45 mcg (5 mcg 9 times per day).

The 20 mcg/mL concentration is intended for patients who are maintained at the 5 mcg dose and who have repeatedly experienced extended treatment times which could result in incomplete dosing. Transitioning patients to the 20 mcg/mL concentration using the I-neb AAD System will decrease treatment times to help maintain patient compliance.

Renal Dose Adjustments

Dose adjustment is not required.

Liver Dose Adjustments

Because iloprost elimination is reduced in patients with impaired liver function, caution should be exercised during iloprost therapy in patients with at least Child-Pugh Class B hepatic impairment.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Dose adjustment is not required for patients not on dialysis.

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