Berinert

Generic Name: complement C1 esterase inhibitor (KOM ple ment C1 ES ter ase in HIB it or)
Brand Names: Berinert, Cinryze

What is Berinert?

Berinert (complement C1 esterase inhibitor) is a man-made form of a protein that occurs naturally in the blood stream and helps control inflammation in the body. In people with hereditary angioedema, complement C1 esterase inhibitor does not function properly or occurs in low levels.

Berinert is used in people with hereditary angioedema. Berinert is used to treat attacks of angioedema. The Cinryze brand of complement C1 esterase inhibitor is used to prevent attacks of angioedema.

Berinert may also be used for purposes not listed in this medication guide.

Important information

You should not use Berinert if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.

Before you receive Berinert, tell your doctor if you have a history of stroke or blood clot.

Do not give Berinert to a child without medical advice.

Video: Asthma

How to prevent and treat an asthma attack.

Stop the Berinert infusion and get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat.

Other serious side effects may include sudden numbness or weakness, chest pain, confusion, pain or swelling, and problems with vision, speech, or balance.

Berinert is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using Berinert.

Before using Berinert

You should not use Berinert if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.

To make sure you can safely use Berinert, tell your doctor if you have a history of stroke or blood clot.

FDA pregnancy category C. It is not known whether Berinert will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Berinert. It is not known whether complement C1 esterase inhibitor passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Berinert is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using Berinert. Do not give this medication to a child without medical advice.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I use Berinert?

Use Berinert exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Berinert is injected into a vein through an IV. A healthcare provider will give you a Berinert injection in a clinic or hospital setting.

This medication comes with patient instructions for safe and effective use. Ask your doctor or pharmacist if you have any questions.

Berinert is a powder medicine that must be mixed with a liquid (diluent) before using it.

Gently swirl but do not shake the mixed medicine or you may ruin it. The dose should be prepared only when you are ready to to receive than injection.

Mixed Berinert should be clear and colorless. Do not use the mixed medicine if it has changed colors, is cloudy, or has any particles in it. Call your doctor for a new prescription.

Berinert contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.

Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Store the unmixed dry powder in a refrigerator or in a dark cool place. Keep the medicine protected from light and do not allow it to freeze. Throw away any unused vial after the expiration date on the label has passed. After mixing Berinert with the diluent, use it right away or store the mixture at room temperature and use it within 8 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden headache, numbness, weakness, or problems with your speech, vision, or balance.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Berinert side effects

Stop your IV infusion and get emergency medical help if you have any of these signs of an allergic reaction to Berinert: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any other serious side effect, such as:

  • new or worsening pain;

  • sudden numbness or weakness, especially on one side of the body;

  • sudden severe headache, confusion, problems with vision, speech, or balance;

  • stomach pain or swelling;

  • chest pain, sudden cough, rapid breathing, fast heart rate; or

  • pain, swelling, warmth, or redness in one or both legs.

Less serious Berinert side effects may include:

  • nausea, vomiting, stomach pain;

  • altered sense of taste;

  • cold symptoms such as stuffy nose, sneezing, sore throat;

  • mild itching or rash; or

  • mild headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Berinert?

There may be other drugs that can interact with Berinert. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Berinert.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Berinert only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.03. Revision Date: 2013-12-03, 11:43:53 AM.

Severe allergies and anaphylaxis: Learn how epinephrine can save a life. Watch Video

Close
Hide
(web4)