Floxuridine Side Effects

Some side effects of floxuridine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to floxuridine: injectable powder for injection

If you experience any of the following serious side effects from floxuridine, contact your doctor immediately:

• an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);

• severe vomiting;

• diarrhea, frequent bowel movements or watery stools; or

• sores in the mouth or throat; or

• stomach pain or heartburn or black, bloody or tarry stools.

Other, less serious side effects may be more likely to occur. Continue taking floxuridine and talk to your doctor if you experience:

• mild to moderate nausea, vomiting or loss of appetite;

• redness of the palms of the hands or soles of the feet;

• increased eye watering;

• balance problems;

• confusion;

• rash and itching; or

• temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to floxuridine: injectable powder for injection

Other

The manufacturer reports that adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion. The procedural complications of regional arterial infusion include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.

Gastrointestinal

Gastrointestinal side effects frequently include nausea, vomiting, diarrhea, enteritis, and stomatitis. Duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, and acalculous cholecystitis have also been reported.

Hematologic

Hematologic side effects include anemia, leukopenia, and thrombocytopenia.

Hepatic

Hepatic side effects include elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase.

Dermatologic

Dermatologic side effects include alopecia, dermatitis, nonspecific skin toxicity, and rash.

Cardiovascular

Cardiovascular side effects include myocardial ischemia and myocardial injury.

General

General side effects include fever, lethargy, malaise, and weakness.

Other

Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.

Nervous system

Nervous system side effects include neurotoxicity.

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