Floxuridine Side Effects
Not all side effects for floxuridine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to floxuridine: injection powder for solution
In addition to its needed effects, some unwanted effects may be caused by floxuridine. In the event that any of these side effects do occur, they may require medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
You should check with your doctor immediately if any of these side effects occur when taking floxuridine:More common
- sores in mouth and on lips
- stomach pain or cramps
- Black, tarry stools
- nausea and vomiting
- scaling or redness of hands or feet
- swelling or soreness of the tongue
- Blood in urine or stools
- cough or hoarseness
- fever or chills
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on skin
- trouble in walking
- unusual bleeding or bruising
- yellow eyes or skin
Some of the side effects that can occur with floxuridine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common or rare
- Loss of appetite
- skin rash or itching
This medicine sometimes causes temporary thinning of hair. After treatment with floxuridine has ended, normal hair growth should return.
For Healthcare Professionals
Applies to floxuridine: injectable powder for injection
The manufacturer reports that adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion. The procedural complications of regional arterial infusion include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.[Ref]
Gastrointestinal side effects frequently include nausea, vomiting, diarrhea, enteritis, and stomatitis. Duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, and acalculous cholecystitis have also been reported.[Ref]
Hematologic side effects include anemia, leukopenia, and thrombocytopenia.[Ref]
Hepatic side effects include elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase.[Ref]
Dermatologic side effects include alopecia, dermatitis, nonspecific skin toxicity, and rash.[Ref]
Cardiovascular side effects include myocardial ischemia and myocardial injury.[Ref]
General side effects include fever, lethargy, malaise, and weakness.[Ref]
Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.[Ref]
Nervous system side effects include neurotoxicity.[Ref]
1. "Product Information. FUDR Sterile (floxuridine)." Roche Laboratories, Nutley, NJ.
2. Abele R, Alberto P, Kaplan S, Siegenthaler P, Hofmann V, Ryssel HJ, Hartmann D, Holdener EE, Cavalli F "Phase II study of doxifluridine in advanced colorectal adenocarcinoma." J Clin Oncol 1 (1983): 750-4
More about floxuridine
- Other brands: FUDR
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