Floxuridine Side Effects

Please note - some side effects for Floxuridine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Floxuridine - for the Consumer

Floxuridine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Floxuridine:

Fatigue or weakness; hair loss; loss of appetite; nausea; stomach pain or cramps; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; blood in the vomit; chest pain; chills; diarrhea; fever; frequent bowel movements; inflammation of the mouth; pain, redness, bleeding, or swelling at the injection site; severe bleeding; severe or prolonged stomach pain; severe or prolonged vomiting; severe tiredness or weakness; shortness of breath; sore throat; sores on the mouth or lips; swelling of the throat or mouth; unusual bruising or bleeding; vein swelling, tenderness, or inflammation; watery stools; yellowing of the skin or eyes.

Side Effects by Body System

Other

The manufacturer reports that adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion. The procedural complications of regional arterial infusion include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.

Gastrointestinal

Gastrointestinal side effects frequently include nausea, vomiting, diarrhea, enteritis, and stomatitis. Duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, and acalculous cholecystitis have also been reported.

Hematologic

Hematologic side effects include anemia, leukopenia, and thrombocytopenia.

Hepatic

Hepatic side effects include elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase.

Dermatologic

Dermatologic side effects include alopecia, dermatitis, nonspecific skin toxicity, and rash.

Cardiovascular

Cardiovascular side effects include myocardial ischemia and myocardial injury.

General

General side effects include fever, lethargy, malaise, and weakness.

Other

Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.

Nervous system

Nervous system side effects include neurotoxicity.

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