Generic Name: clofarabine (kloe FAR a been)
Brand Names: Clolar

What is Clolar?

Clolar (clofarabine) is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Clolar is used to treat acute lymphoblastic leukemia (a type of blood cancer) in children and young adults up to 21 years old.

Clolar is usually given after other cancer medicines have been tried without successful treatment.

Important information

Clolar can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

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Clolar can harm your liver or kidneys. Call your doctor if you have lower back pain, little or no urinating, or blood in your urine.

Before receiving Clolar

To make sure Clolar is safe for you, tell your doctor if you have:

  • liver disease; or

  • kidney disease.

FDA pregnancy category D. Do not use Clolar if you are pregnant. It could harm the unborn baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

Use birth control to prevent pregnancy while you are receiving Clolar, whether you are a man or a woman. Clolar use by either parent may cause birth defects.

It is not known whether clofarabine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving Clolar.

How is Clolar given?

Clolar is injected into a vein through an IV. A healthcare provider will give you this injection.

Clolar is usually given daily for 5 days in a row during one or more treatment cycles. Your doctor will determine how many treatment cycles you will receive and how often.

You may receive other medications to help prevent certain side effects of Clolar.

Clolar can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your kidney or liver function may also need to be tested. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Clolar injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Clofarabine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Clolar side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Clolar: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • runny or stuffy nose, cough, rapid heart rate, trouble breathing, swelling and pain in any part of your body;

  • lower back pain, blood in your urine, little or no urinating;

  • numbness or tingly feeling around your mouth;

  • muscle weakness, tightness, or contraction, overactive reflexes;

  • pain, redness, numbness, and peeling skin on your hands or feet;

  • fast or slow heart rate, weak pulse, feeling short of breath, confusion, fainting;

  • numbness or redness on the palms of your hands or the soles of your feet;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • jaundice (yellowing of the skin or eyes); or

  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, mouth sores, unusual weakness.

Common Clolar side effects may include:

  • nausea, vomiting, diarrhea;

  • headache, feeling tired or anxious;

  • mild itching or skin rash; or

  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Clolar?

Tell your doctor about all other medications you use, especially blood pressure medications.

Clolar can harm your liver or kidneys. This effect is increased when you also use other medicines harmful to the liver or kidneys. During your 5-day treatment with Clolar, you may need to avoid using certain medications. Many other drugs (including some over-the-counter medicines) can be harmful to the liver or kidneys, such as:

  • leflunomide, teriflunomide;

  • methotrexate;

  • an antibiotic, antifungal medicine, antiviral medicine, sulfa drug, or tuberculosis medicine;

  • birth control pills or hormone replacement therapy;

  • heart or blood pressure medication;

  • cholesterol-lowering medications--Crestor, Lipitor, Pravachol, Simcor, Vytorin, Zocor, and others;

  • gout or arthritis medications (including gold injections);

  • HIV/AIDS medications;

  • medicines to treat a bowel disorder;

  • medication to prevent organ transplant rejection;

  • medicines to treat mental illness;

  • other cancer medications;

  • pain or arthritis medicines--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

  • seizure medication--carbamazepine, phenytoin, and others; or

  • steroids (prednisone and others).

This list is not complete. Other drugs may interact with Clolar, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Clolar.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Clolar only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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