Eribulin Side Effects
Some side effects of eribulin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to eribulin: intravenous solution
Along with its needed effects, eribulin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking eribulin:More common
- Black, tarry stools
- bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or cloudy urine
- body aches or pain
- burning, numbness, tingling, or painful sensations
- decreased urine
- decreased weight
- difficult or labored breathing
- difficult, burning, or painful urination
- dry mouth
- ear congestion
- frequent urge to urinate
- increased thirst
- irregular heartbeat
- loss of appetite
- loss of voice
- lower back or side pain
- mood changes
- muscle pain or cramps
- nasal congestion
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- pale skin
- rapid weight gain
- runny nose
- shortness of breath
- sore throat
- tightness in the chest
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- weakness in the arms, hands, legs, or feet
- irregular heartbeat, recurrent
Some side effects of eribulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Acid or sour stomach
- back pain
- bone pain
- change in taste
- cracked lips
- difficulty having a bowel movement (stool)
- difficulty with moving
- difficulty with swallowing
- hair loss or thinning of the hair
- lack or loss of strength
- loss of taste
- muscle spasm or weakness
- muscle stiffness
- pain in the arms or legs
- pain in the joints
- sores, ulcers, or white spots on the lips, tongue, or inside the mouth
- stomach discomfort, upset, or pain
- swelling or inflammation of the mouth
- trouble sleeping
- unable to sleep
- watering of the eyes
- weight loss
For Healthcare Professionals
Applies to eribulin: intravenous solution
Hematologic side effects have included neutropenia (82%), anemia (58%), febrile neutropenia, and thrombocytopenia.
In one study, grade 3 neutropenia occurred in 28% of patients, 29% experience grade 4 neutropenia, and 5% of patients experienced febrile neutropenia. Dose reductions due to neutropenia occurred in 12% of patients and discontinuation was required in less than 1% of patients. Grade 3 or greater thrombocytopenia was reported in 1% of patients. Granulocyte colony-stimulating factor or granulocyte-macrophage colony-stimulating factor was used in 19% of patients treated with eribulin.
Nervous system side effects have included peripheral neuropathy (35%), headache (19%), peripheral motor neuropathy, polyneuropathy, peripheral sensory neuropathy, paraesthesia, dysgeusia, and dizziness.
Gastrointestinal side effects have included nausea (35%), constipation (25%), anorexia (20%), diarrhea (18%), vomiting (18%), mucosal inflammation (9%), dyspepsia, abdominal pain, stomatitis, and dry mouth. Postmarketing gastrointestinal side effects have included reports of pancreatitis.
Cardiovascular side effects have included QT interval prolongation and peripheral edema.
Dermatologic side effects have included alopecia (45%) and rash.
Genitourinary side effects have included urinary tract infection (10%).
Hepatic side effects have included increased liver enzymes and increased bilirubin.
Metabolic side effects have included weight loss (21%) and hypokalemia.
Musculoskeletal side effects have included arthralgia (22%), myalgia (22%), back pain (16%), bone pain (12%), pain in extremity (11%), muscle spasms, and muscular weakness.
Ocular side effects have included increased lacrimation.
Other side effects have included asthenia (54%), fatigue (54%) and pyrexia (21%).
Psychiatric side effects have included insomnia and depression.
Respiratory side effects have included dyspnea (16%), cough (14%), and upper respiratory tract infection.
More about eribulin
- Other brands: Halaven
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