Enzalutamide Side Effects

Not all side effects for enzalutamide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to enzalutamide: oral capsule liquid filled

In addition to its needed effects, some unwanted effects may be caused by enzalutamide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking enzalutamide:

More common
  • Back pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in urine
  • blurred vision
  • chest pain
  • cough
  • cough with mucus
  • difficulty breathing
  • dizziness
  • fever or chills
  • headache
  • loss of bladder control
  • loss of bowel control
  • nervousness
  • no sensation in the legs
  • painful or difficult urination
  • pounding in the ears
  • rapid weight gain
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • unable to move legs
  • unusual weight gain or loss
  • wheezing
Less common
  • Confusion or excitement
  • fainting
  • falling
  • lightheadedness
  • loss of memory
  • mental depression or anxiety
  • nightmares or unusually vivid dreams
  • problems with memory or attention span
  • rapid, shallow breathing
  • trouble performing routine tasks
  • Seizures

Some of the side effects that can occur with enzalutamide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • bone pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty in moving
  • dry throat
  • ear congestion
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • hoarseness
  • joint pain
  • lack or loss of strength
  • loss of voice
  • muscle pain, stiffness, or weakness
  • nervousness
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms and occasionally, upper chest
  • sensation of spinning
  • stuffy or runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • trouble sleeping
  • unusual tiredness or weakness
  • voice changes
Less common
  • Bloody nose
  • dry skin
  • frequent urination
  • itching skin
  • pale-colored urine

For Healthcare Professionals

Applies to enzalutamide: oral capsule


Very common (10% or more): Hot flush (20.3%), peripheral edema (15.4%)
Common (1% to 10%): Hypertension (6.4%)


Common (1% to 10%): Pruritus (3.8%), dry skin (3.5%)


Very common (10% or more): Diarrhea (21.8%)


Common (1% to 10%): Hematuria (6.9%), pollakiuria (4.8%)


Very common (10% or more): Neutropenia (15%)
Uncommon (0.1% to 1%): Thrombocytopenia (0.5%)
Frequency not reported: Small increases in mean QTc interval


Very common (10% or more): Elevations in ALT (10%)
Common (1% to 10%): Elevations in bilirubin (3%)


Very common (10% or more): Back pain (26.4%), arthralgia (20.5%), musculoskeletal pain (15%)
Common (1% to 10%): Muscular weakness (9.8%), musculoskeletal stiffness (2.6%)

Nervous system

Very common (10% or more): Headache (12.1%)
Common (1% to 10%): Dizziness, includes vertigo (9.5%), spinal cord compression and cauda equina syndrome (7.4%), paresthesia (6.6%), mental impairment, includes amnesia, memory impairment, cognitive disorder, and disturbance in attention (4.3%), hypoesthesia (4%)


Very common (10% or more): Asthenic conditions, including asthenia and fatigue (50.6%)
Common (1% to 10%): Falls (4.6%), non-pathologic fractures (4%)


Common (1% to 10%): Insomnia (8.8%), anxiety (6.5%), hallucinations (1.6%)


Very common (10% or more): Upper respiratory tract infection, includes nasopharyngitis, sinusitis, rhinitis, pharyngitis, and laryngitis (10.9%)
Common (1% to 10%): Lower respiratory tract and lung infection, includes pneumonia, and bronchitis (8.5%), epistaxis (3.3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.