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Enzalutamide Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Prostate Cancer

Initial dose: 160 mg (four 40 mg capsules) orally once daily.

Renal Dose Adjustments

Data not available for severe renal impairment and end-stage renal disease.
No adjustment recommended with mild to moderate renal impairment.

Liver Dose Adjustments

Data not available for severe hepatic impairment.
No adjustment recommended with mild or moderate hepatic impairment.

Dose Adjustments

Enzalutamide should be withheld for one week or until Grade 3 or greater side effects improve to less than or equal to a Grade 2. A dose reduction to 80 or 120 mg may be necessary.

Reduce the dose to 80 mg daily if co-administered with a strong CYP2C8 inhibitor.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available.

Other Comments

Administration advice: Swallow whole, do not dissolve or open capsules.

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