The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Prostate Cancer
USUAL ADULT DOSE:
160 mg (four 40 mg capsules) orally once daily
-Swallow capsules whole.
-Take with or without food.
Use: Metastatic castration-resistant prostate cancer with previous docetaxel therapy
Renal Dose Adjustments
Mild or moderate renal impairment: No adjustment recommended.
Severe renal impairment or end-stage renal disease: Caution recommended.
Liver Dose Adjustments
Mild hepatic impairment (Child-Pugh A): No adjustment recommended.
Moderate hepatic impairment (Child-Pugh B): Caution recommended.
Severe hepatic impairment (Child-Pugh C): Not recommended.
Grade 3 or more toxicity or intolerable side effect:
-Withhold dosing for one week or until symptoms improve to Grade 2 or less, then resume at usual daily dose or reduce daily dose to 120 mg or 80 mg if necessary.
Strong CYP450 2C8 inhibitors:
-Avoid concomitant use if possible. If concomitant use is necessary, reduce drug dose to 80 mg once daily.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available.
-This drug can be taken without regard to food.
-This drug is not indicated for use in women. Fetal harm may occur with this drug; avoid pregnancy during treatment. If pregnancy occurs, contact your doctor immediately.
-If your sexual partner is pregnant, you must use a condom during and for 3 months after treatment with this drug. If your sexual partner has the possibility of becoming pregnant, you must use a condom and another form of birth control during and for 3 months after treatment with this drug. Talk with your doctor if you have questions about birth control.
-Due to risk of seizure associated with this drug, tell your doctor if you have a history of seizures or any other predisposing factors, including but not limited to brain injury, stroke, or brain tumors.
-Due to risk of seizure associated with this drug, avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others.
-This drug may cause side effects including but not limited to fatigue, back pain, diarrhea, infections, dizziness, falls, and problems thinking clearly. Tell your doctor if you have any side effect that bothers you or does not go away.
-Swallow drug capsules whole with water. Do not chew, dissolve, or open the capsules. You can take this drug with or without food.
-This drug can interact with several medications. Tell your doctor about all the medications you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements.
More about enzalutamide
- Other brands: Xtandi