Enzalutamide Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Prostate Cancer

USUAL ADULT DOSE:
160 mg (four 40 mg capsules) orally once daily

Comments:
-Swallow capsules whole.
-Take with or without food.

Use: Metastatic castration-resistant prostate cancer with previous docetaxel therapy

Renal Dose Adjustments

Mild or moderate renal impairment: No adjustment recommended.
Severe renal impairment or end-stage renal disease: Caution recommended.

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh A): No adjustment recommended.
Moderate hepatic impairment (Child-Pugh B): Caution recommended.
Severe hepatic impairment (Child-Pugh C): Not recommended.

Dose Adjustments

Grade 3 or more toxicity or intolerable side effect:
-Withhold dosing for one week or until symptoms improve to Grade 2 or less, then resume at usual daily dose or reduce daily dose to 120 mg or 80 mg if necessary.

Strong CYP450 2C8 inhibitors:
-Avoid concomitant use if possible. If concomitant use is necessary, reduce drug dose to 80 mg once daily.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:
-This drug can be taken without regard to food.

Patient advice:
-This drug is not indicated for use in women. Fetal harm may occur with this drug; avoid pregnancy during treatment. If pregnancy occurs, contact your doctor immediately.
-If your sexual partner is pregnant, you must use a condom during and for 3 months after treatment with this drug. If your sexual partner has the possibility of becoming pregnant, you must use a condom and another form of birth control during and for 3 months after treatment with this drug. Talk with your doctor if you have questions about birth control.
-Due to risk of seizure associated with this drug, tell your doctor if you have a history of seizures or any other predisposing factors, including but not limited to brain injury, stroke, or brain tumors.
-Due to risk of seizure associated with this drug, avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others.
-This drug may cause side effects including but not limited to fatigue, back pain, diarrhea, infections, dizziness, falls, and problems thinking clearly. Tell your doctor if you have any side effect that bothers you or does not go away.
-Swallow drug capsules whole with water. Do not chew, dissolve, or open the capsules. You can take this drug with or without food.
-This drug can interact with several medications. Tell your doctor about all the medications you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

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