Edetate calcium disodium Side Effects

Some side effects of edetate calcium disodium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to edetate calcium disodium: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking edetate calcium disodium: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

• urinating less than usual or not at all;

• drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;

• swelling, weight gain, feeling short of breath;

• feeling like you might pass out; or

• fast, slow, or uneven heart rate.

Less serious side effects include:

• fever, chills, tired feeling, and muscle or joint pain;

• numbness or tingly feeling;

• tremors;

• runny or stuffy nose, sneezing, water eyes;

• mild skin rash;

• headache; or

• pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to edetate calcium disodium: compounding powder, injectable solution

Cardiovascular

Cardiovascular side effects have included hypotension and cardiac rhythm irregularities.

Gastrointestinal

Gastrointestinal side effects have included cheilosis, nausea, vomiting, anorexia, and excessive thirst.

General

General side effects have included pain at the intramuscular injection site, fever, chills, malaise, and fatigue.

Genitourinary

Genitourinary side effects have included glycosuria, proteinuria, microscopic hematuria, and large epithelial cells in urinary sediment.

Hematologic

Hematologic side effects have included transient bone marrow depression and anemia.

Hepatic

Hepatic side effects are mild increases in SGOT and SGPT, which are common, and return to normal within 48 hours after cessation of therapy.

Hypersensitivity

Hypersensitivity side effects have included histamine-like reactions and rash.

Immunologic

Immunologic side effects have included histamine-like reactions (sneezing, nasal congestion, and lacrimation) and rash.

Metabolic

Metabolic side effects have included zinc deficiency and hypercalcemia.

Musculoskeletal

Musculoskeletal side effects have included myalgia and arthralgia.

Nervous system

Nervous system side effects have included tremors, headache, numbness, and tingling.

Renal

Renal side effects have included acute necrosis of proximal tubules (which may result in fatal nephrosis) and infrequent changes in distal tubules and glomeruli.

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