Edetate Calcium Disodium Dosage

This dosage information may not include all the information needed to use Edetate Calcium Disodium safely and effectively. See additional information for Edetate Calcium Disodium.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Lead Poisoning - Mild

For asymptomatic adult patients whose blood lead level is < 70 mcg/dL but > 20 mcg/dL (World Health Organization recommended upper allowable level):

1000 mg/m2/day given intravenously or intramuscularly

Therapy of lead poisoning in adult patients with edetate calcium disodium is continued over a period of five days. Therapy is then interrupted for 2 to 4 days to allow redistribution of the lead and to prevent severe depletion of zinc and other essential metals. Two courses of treatment are usually employed; however, it depends on severity of the lead toxicity and the patient's tolerance of the drug.

Edetate calcium disodium is equally effective whether administered intravenously or intramuscularly. The intramuscular route is used for all patients with overt lead encephalopathy.

Usual Adult Dose for Lead Poisoning - Severe

When the blood lead level is > 70 mcg/dL or clinical symptoms consistent with lead poisoning are present, it is recommended that edetate calcium disodium be used in conjunction with BAL (dimercaprol). Clinician should consult latest published protocols and/or a local poison control information center for dosing.

Usual Pediatric Dose for Lead Poisoning - Mild

For asymptomatic pediatric patients whose blood lead level is < 70 mcg/dL but > 20 mcg/dL (World Health Organization recommended upper allowable level):

1000 mg/m2/day given intravenously or intramuscularly

Therapy of lead poisoning in pediatric patients with edetate calcium disodium is continued over a period of five days. Therapy is then interrupted for 2 to 4 days to allow redistribution of the lead and to prevent severe depletion of zinc and other essential metals. Two courses of treatment are usually employed; however, it depends on severity of the lead toxicity and the patient's tolerance of the drug.

Edetate calcium disodium is equally effective whether administered intravenously or intramuscularly. The intramuscular route is used for all patients with overt lead encephalopathy and this route is preferred by some for young pediatric patients.

Usual Pediatric Dose for Lead Poisoning - Severe

When the blood lead level is > 70 mcg/dL or clinical symptoms consistent with lead poisoning are present, it is recommended that edetate calcium disodium be used in conjunction with BAL (dimercaprol). Clinician should consult latest published protocols and/or a local poison control information center for dosing.

Renal Dose Adjustments

For adults with lead nephropathy the following dosing regimen has been suggested.

Serum creatinine 2 to 3 mg/dL:
500 mg/m2 every 24 hours for 5 days

Serum creatinine 3 to 4 mg/dL:
500 mg/m2 every 48 hours for 3 doses

Serum creatinine above 4 mg/dL:
500 mg/m2 once weekly

These regimen may be repeated at one month intervals.

Liver Dose Adjustments

Edetate calcium disodium is contraindicated in patients with active hepatitis.

Dialysis

No data available

Other Comments

When a source for the lead intoxication has been identified, the patient should be removed from the source, if possible.

Hide
(web5)