Dyrenium Side Effects

Generic Name: triamterene

Note: This page contains information about the side effects of triamterene. Some of the dosage forms included on this document may not apply to the brand name Dyrenium.

Not all side effects for Dyrenium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to triamterene: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by triamterene (the active ingredient contained in Dyrenium). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking triamterene:

Incidence not known
  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chills
  • clay-colored stools
  • cloudy urine
  • confusion
  • convulsions
  • cough
  • dark urine
  • decreased urine output
  • depression
  • difficulty breathing
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting spells
  • fast or irregular heartbeats
  • fever
  • headache
  • hives
  • hostility
  • increased thirst
  • irritability
  • itching
  • joint pain
  • lethargy
  • loss of appetite
  • loss of consciousness
  • mood changes
  • muscle pain or cramps
  • muscle twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain in the groin or genitals
  • pain in the lower back or side
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid or unusual weight gain
  • seizures
  • sharp back pain just below the ribs
  • shortness of breath
  • skin rash
  • stupor
  • swelling of the face, ankles, feet, or hands
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weakness or heaviness of the legs
  • wheezing
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking triamterene, get emergency help immediately:

Symptoms of overdose
  • Blurred vision
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • indigestion
  • pain or weakness in the hands or feet
  • passing of gas
  • stomach fullness or discomfort
  • sweating
  • trembling

Some of the side effects that can occur with triamterene may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Increased sensitivity of skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to triamterene: compounding powder, oral capsule


Triamterene (the active ingredient contained in Dyrenium) is generally well-tolerated, especially in patients with adequate urine output. Side effects are reported in less than 1% of patients.


Metabolic abnormalities include hyperkalemia, which is more likely in the elderly, diabetic, and in patients with renal insufficiency. It is recommended that serum potassium concentrations be monitored, and that an electrocardiogram be obtained if hyperkalemia is suspected to check for peaked T waves and QRS segment changes.

The presence of an arrhythmia or widened QRS complex associated with hyperkalemia requires prompt administration of 10% calcium gluconate 10 to 20 mL intravenously over a 20 to 30 minute interval. Noncardiotoxic hyperkalemia usually responds to 10 units of regular insulin plus glucose 25 grams (as a 20% solution infused over 30 minutes) and consideration of sodium bicarbonate 40 to 150 mEq infused over a 30 to 60 minute interval. Insulin-dependent diabetic patients with preexisting hyperglycemia may not require the concomitant glucose infusion.


Gastrointestinal side effects, such as nausea and vomiting, may be lessened by administering the drug after meals.


Renal insufficiency, manifested as increased serum creatinine and BUN, has been reported in less than 1% of patients, but is far more likely, even in patients without preexisting renal insufficiency, if nonsteroidal anti-inflammatory drugs are being coadministered. Triamterene renal calculi is estimated to occur in 1/1,500 to 1/2,000 patients. Rare cases of interstitial nephritis and triamterene (the active ingredient contained in Dyrenium) bladder calculi are reported.

Triamterene is less soluble in solutions with a pH below 6, becoming crystallized and precipitating calculi formation under certain circumstances. In addition, triamterene alone, and when combined with hydrochlorothiazide, is associated with interstitial nephritis and acute renal failure in rare cases.


Hypersensitivity reactions include rare cases of drug fever, hepatitis, photosensitive dermatitis, and erythema multiforme. In some cases, other drugs were coadministered, making implication of triamterene (the active ingredient contained in Dyrenium) difficult.


Triamterene (the active ingredient contained in Dyrenium) inhibits dihydrofolate reductase, resulting in decreased folate production. This may be important in patients who have borderline folate stores, such as pregnant women and alcohol abusers.

Hematologic side effects include thrombocytopenia and macrocytic anemia. Rare cases of drug-induced dose-dependent hemagglutination resulting in acute intravascular hemolysis is reported.


Hepatic side effects are rare. A case of cholestatic jaundice and centrolobular necrosis of the liver is reported, thought to be due to hypersensitivity. Triamterene (the active ingredient contained in Dyrenium) may cause a spurious elevation in serum lactate dehydrogenase concentrations.


A laboratory abnormality is spurious elevation of lactate dehydrogenase concentrations.

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