Duexis Side Effects
Generic Name: famotidine / ibuprofen
Note: This page contains information about the side effects of famotidine / ibuprofen. Some of the dosage forms included on this document may not apply to the brand name Duexis.
Not all side effects for Duexis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to famotidine / ibuprofen: oral tablet
In addition to its needed effects, some unwanted effects may be caused by famotidine / ibuprofen. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking famotidine / ibuprofen:Less common
- Abdominal or stomach pain, cramping, or burning
- bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or black, tarry stools
- blurred vision
- clay-colored stools
- cloudy urine
- dark-colored urine
- difficult, burning, or painful urination
- frequent urge to urinate
- general feeling of discomfort or illness
- general feeling of tiredness or weakness
- joint pain
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle aches and pains
- pale skin
- pounding in the ears
- rapid weight gain
- runny nose
- severe stomach pain
- slow or fast heartbeat
- sore throat
- stomach pain, continuing
- tingling of the hands or feet
- trouble sleeping
- troubled breathing with exertion
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting of blood or material that looks like coffee grounds
- yellow eyes or skin
- Blistering, peeling, or loosening of the skin
- change in consciousness
- confusion as to time, place, or person
- cracks in the skin
- darkening of the skin
- dry mouth
- holding false beliefs that cannot be changed by fact
- loss of consciousness
- loss of heat from the body
- mental depression
- pain in lower back or side
- pains in the chest, groin, or legs, especially calves of the legs
- red skin lesions, often with a purple center
- red, irritated eyes
- red, swollen skin
- scaly skin
- severe headaches of sudden onset
- sores, ulcers, or white spots in the mouth or on the lips
- stiff neck or back
- sudden loss of coordination
- sudden onset of shortness of breath for no apparent reason
- sudden onset of slurred speech
- sudden vision changes
- troubled breathing with exertion
- unusual excitement, nervousness, or restlessness
Some of the side effects that can occur with famotidine / ibuprofen may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common
- Acid or sour stomach
- back pain
- body aches or pain
- cough producing mucus
- difficulty having a bowel movement (stool)
- difficulty with moving
- ear congestion
- loss of voice
- muscle stiffness
- nasal congestion
- pain or tenderness around the eyes and cheekbones
- stuffy nose
For Healthcare Professionals
Applies to famotidine / ibuprofen: oral tablet
Cardiovascular side effects associated with famotidine have included decreases in stroke volume and cardiac output and may be clinically significant in patients with preexisting cardiac dysfunction. A variety of arrhythmias, including bradycardia, tachycardia, AV conduction defects (including AV block), and palpitations have also been reported rarely. Acquired long QT syndrome has been reported in at least three cases including a man with decompensated cirrhosis. Cardiovascular side effects associated with ibuprofen have included peripheral edema (1% to 3%) and elevated blood pressure (less than 1%). This may be important in some patients with preexisting hypertension or congestive heart failure. A rare case of painful, persistent peripheral cyanosis and swelling of the fingers and toes which progressed to desquamation and digital pitting infarctions has been associated with ibuprofen.
Dermatologic side effects associated with famotidine have included alopecia, acne, pruritus, dry skin, and flushing. Dermatologic side effects associated with ibuprofen have been reported rarely. These have included maculopapular rash, pruritus, vesiculobullous eruptions, erythema multiforme, vasculitis, Stevens-Johnson syndrome, and alopecia. Photosensitivity reactions have been reported, although causality is unknown. At least one case of acute generalized exanthematous pustulosis has also been reported.
Endocrine side effects associated with famotidine have included antiandrogen effects of reversible hyperprolactinemia and gynecomastia.
Gastrointestinal side effects associated with famotidine have included nausea, vomiting, diarrhea, constipation, abdominal discomfort, anorexia, and dry mouth. Gastrointestinal (GI) side effects associated with ibuprofen have been reported most frequently (up to 25% of patients). They have usually been mild and transient. They have included dyspepsia, nausea, vomiting, diarrhea, abdominal pain, and flatulence. More serious GI effects have been uncommonly reported and have included occult blood loss, ulcer, GI hemorrhage with or without perforation, and pancreatitis. In addition, small bowel enteropathies and ibuprofen-associated colitis have been reported. Bloody vomiting has occurred in overdose. Colonic and pyloric channel strictures have also been reported.
Hematologic side effects associated with famotidine have included neutropenia, and rarely, reversible thrombocytopenia, agranulocytosis, pancytopenia, and leucopenia. Hematologic side effects associated with ibuprofen have included platelet dysfunction, neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia, thrombocytopenia, eosinophilia, and decreases in hemoglobin and hematocrit. At least one case of hemolytic uremic syndrome has also been reported.
Hepatic side effects associated with famotidine have included mild elevations of liver function tests. The clinical significance of these elevations is unknown. Jaundice and cholestatic jaundice have been reported infrequently. Cases of drug-induced hepatitis have also been reported. Hepatic side effects associated with ibuprofen have included elevations in liver function tests in up to 15% of patients. Rarely, jaundice, cholestasis, hepatitis, and hepatic failure have been reported. Ibuprofen has also been implicated in the so called acute vanishing bile duct syndrome in children and in cases of acute hepatitis in patients with established stable, chronic hepatitis C infection.
Hypersensitivity side effects associated with famotidine have infrequently included anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival infection, toxic epidermal necrolysis (very rare), erythema multiforme, and Stevens-Johnson syndrome (very rare). Hypersensitivity side effects associated with ibuprofen have included erythematous or urticaria rashes, pruritus, angioedema, bronchospasm, and anaphylactoid reactions, particularly in patients with the syndrome of asthma, nasal polyps, and angioedema and/or bronchospastic reactivity to aspirin. Rare cases of systemic reactions, including interstitial nephritis, diffuse pulmonary infiltrates, and Stevens-Johnson syndrome have been reported. Toxic epidermal necrolysis has also been reported, although causality is unknown. At least one case of an acute anaphylactic reaction has also been reported.
Metabolic side effects associated with ibuprofen have included hyponatremia and syndrome of inappropriate antidiuretic hormone (SIADH). In addition, gynecomastia, hypoglycemia, and acidosis have been reported, although causality is unknown. Hyperkalemia has occurred in ibuprofen overdose.
Musculoskeletal side effects associated with famotidine have infrequently included musculoskeletal pain including muscle cramps and arthralgia.
Nervous system side effects associated with famotidine have included headache, dizziness, seizures, paresthesia, and somnolence. Nervous system side effects associated with ibuprofen have been reported rarely. These have included headache, drowsiness, and dizziness. Aseptic meningitis associated with ibuprofen has been described in several case reports. In addition, paresthesia and pseudotumor cerebri have been reported, although causality is unknown.
Ocular side effects associated with ibuprofen have included blurred vision (less than 1%), scotomata, and diplopia. In addition, at least one case of corneal verticillata has also been reported during ibuprofen use.
Other side effects associated with famotidine have infrequently included tinnitus, fever, asthenia, fatigue, and taste disorder. Other side effects associated with ibuprofen have included tinnitus (1% to 3%) and vertigo.
Psychiatric side effects associated with famotidine have included depression, anxiety, insomnia, hallucinations, and decreased libido. Psychiatric side effects associated with ibuprofen have included case reports of pseudodementia and psychotic exacerbation.
Renal side effects associated with famotidine have included rare cases of interstitial nephritis. Renal side effects associated with ibuprofen have included mild renal insufficiency, urinary retention, nephrotic syndrome with or without renal failure, acute renal failure due to tubulointerstitial nephritis, papillary necrosis, and acute tubular necrosis.
Respiratory side effects associated with famotidine have rarely included bronchospasm and interstitial pneumonia. Respiratory side effects associated with ibuprofen have included noncardiogenic pulmonary edema.
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