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Generic Name: famotidine and ibuprofen (fam OH ti deen and EYE bue PROE fen)
Brand Names: Duexis

What is Duexis?

Duexis contains a combination of famotidine and ibuprofen. Famotidine is a histamine blocker. Famotidine works by decreasing the amount of acid the stomach produces.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Duexis is a combination medicine. Ibuprofen treats the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.

Duexis may also be used for purposes not listed in this medication guide.

Important information

You should not use Duexis if you are allergic to ibuprofen (Advil, Motrin), famotidine (Pepcid), aspirin, other NSAIDs (non-steroidal anti-inflammatory drugs), or other stomach acid reducers (such as Tagamet, Zantac, or Axid). Do not use Duexis if you are more than 29 weeks (7 months) pregnant. Taking ibuprofen during this time may harm the unborn baby.

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use Duexis just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Duexis, especially in older adults.

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Before taking this medicine

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use Duexis just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Duexis, especially in older adults.

You should not use Duexis if you are allergic to famotidine or ibuprofen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if it is safe for you to take Duexis if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

  • a history of heart attack, stroke, or blood clot;

  • a history of stomach ulcers or bleeding;

  • asthma;

  • liver or kidney disease;

  • Crohn's disease, inflammatory bowel disease, or ulcerative colitis;

  • a bleeding or blood clotting disorder;

  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, or lupus;

  • fluid retention; or

  • if you smoke.

Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Do not use Duexis without a doctor's advice if you are pregnant.

It is not known whether famotidine and ibuprofen passes into breast milk or if it could harm a nursing baby. Do not use Duexis without a doctor's advice if you are breast-feeding a baby.

Do not give Duexis to a child without the advice of a doctor.

How should I take Duexis?

Take Duexis exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Duexis is usually taken 3 times each day. Follow your doctor's instructions.

Do not take more than your recommended dose. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Duexis needed to get relief from your pain, swelling, or fever.

Do not crush, chew, or break a Duexis tablet. Swallow the tablet whole.

If you use Duexis long-term, you may need frequent medical tests.

If you also use a steroid medication, do not stop using it suddenly or you may have unpleasant withdrawal symptoms. Talk with your doctor about tapering your steroid dose before stopping completely.

Store Duexis at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Duexis dosing information

Usual Adult Dose of Duexis for Osteoarthritis:

Famotidine-ibuprofen 26.6 mg-800 mg: 1 tablet orally 3 times daily

Usual Adult Dose of Duexis for Rheumatoid Arthritis:

Famotidine-ibuprofen 26.6 mg-800 mg: 1 tablet orally 3 times daily

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Duexis?

Avoid using other medications that contain ibuprofen.

Ask a doctor or pharmacist before using any other cold, allergy, or pain medicine. Ibuprofen and other NSAIDs are contained in many combination medicines. Taking certain products together can cause you to get too much ibuprofen. Check the label to see if a medicine contains ibuprofen or similar NSAIDs (aspirin, naproxen, ketoprofen).

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Duexis side effects

Get emergency medical help if you have signs of an allergic reaction to Duexis: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using ibuprofen and call your doctor at once if you have:

  • changes in your vision;

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • the first sign of any skin rash, no matter how mild;

  • severe headache with neck stiffness, chills, and/or seizure (convulsions);

  • signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

  • low red blood cells (anemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  • severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Duexis side effects may include:

  • nausea, stomach pain;

  • diarrhea, constipation; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Duexis?

Ask your doctor before taking Duexis if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use Duexis if you are also using any of the following drugs:

  • cholestyramine;

  • lithium;

  • methotrexate;

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • heart or blood pressure medication, including a diuretic or "water pill"; or

  • steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with famotidine and ibuprofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Duexis.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Duexis only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 3.01. Revision Date: 2016-01-04, 4:41:24 PM.

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