Cometriq Side Effects

Generic Name: cabozantinib

Note: This page contains information about the side effects of cabozantinib. Some of the dosage forms included on this document may not apply to the brand name Cometriq.

Not all side effects for Cometriq may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cabozantinib: oral capsule

Along with its needed effects, cabozantinib (the active ingredient contained in Cometriq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cabozantinib:

More common
  • Blurred vision
  • burning, numbness, tingling, or painful sensations
  • dehydration
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • nervousness
  • pain in the chest, groin, or legs, especially the calves
  • pounding in the ears
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • severe, sudden headache
  • skin ulcers
  • slow or fast heartbeat
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • tingling of the hands and feet
  • unsteadiness or awkwardness
  • vision changes
  • weakness in the arms, hands, legs, or feet
Less common
  • Bleeding gums
  • bloody, black, or tarry stools
  • coughing up blood
  • heartburn
  • heavy jaw feeling
  • increased menstrual flow or vaginal bleeding
  • indigestion
  • loosening of a tooth
  • nausea
  • nosebleeds
  • pain, swelling, or numbness in the mouth or jaw
  • paralysis
  • prolonged bleeding from cuts
  • red or dark brown urine
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuing
Rare
  • Confusion
  • disturbed color perception
  • double vision
  • halos around lights
  • night blindness
  • overbright appearance of lights
  • seizures
  • tunnel vision

Some side effects of cabozantinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • bleeding after defecation
  • change in taste
  • changes in hair color
  • decreased appetite
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dry skin
  • fear
  • hair loss or thinning of the hair
  • hoarseness
  • lack or loss of strength
  • loss of taste
  • muscle pain or stiffness
  • muscle spasm
  • pain in the joints
  • rash
  • sore throat
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • uncomfortable swelling around the anus
  • voice changes
  • vomiting

For Healthcare Professionals

Applies to cabozantinib: oral capsule

General

Fatal adverse reactions occurred in 6% of patients resulting from hemorrhage, pneumonia, septicemia, fistulas, cardiac arrest, respiratory failure, and unspecified death.

The most frequent adverse reactions leading to discontinuation in treatment include hypocalcemia, increased lipase, palmar-plantar erythrodysesthesia syndrome (PPES), diarrhea, fatigue, hypertension, nausea, pancreatitis, tracheal fistula formation, and vomiting.

Cardiovascular

Very common (10% or more): Hypertension (33%)
Common (1% to 10%): Hypotension (7%)

Dermatologic

Very common (10% or more): PPES (50%), hair color changes/depigmentation, graying (34%), rash (19%), dry skin (19%), alopecia (16%), erythema (11%)
Common (1% to 10%): Hyperkeratosis (7%)

Gastrointestinal

Very common (10% or more): Diarrhea (63%), stomatitis (51%; includes aphthous stomatitis, mouth ulcerations, and mucosal inflammation), nausea (43%), oral pain (36%; includes oropharyngeal pain, glossitis, burning mouth syndrome, and glossodynia), abdominal pain (27%; includes lower and upper abdominal pain, abdominal rigidity and tenderness, and esophageal pain, constipation (27%), vomiting (24%), dysphagia (13%), dyspepsia (11%)
Common (1% to 10%): Hemorrhoids (9%)

Hematologic

Very common (10% or more): Lymphopenia (53%), neutropenia (35%), thrombocytopenia (35%)

Metabolic

Very common (10% or more): Decreased weight (48%), decreased appetite (46%)
Common (1% to 10%): Dehydration (7%)

Musculoskeletal

Very common (10% or more): Arthralgia (14%), muscle spasms (12%)
Common (1% to 10%): Musculoskeletal chest pain (9%)

Nervous system

Very common (10% or more): Fatigue (41%), dysgeusia (34%), asthenia (21%), headache (18%), dizziness (14%)
Common (1% to 10%): Paresthesia (7%), peripheral sensory neuropathy (7%), peripheral neuropathy (5%)

Other

Laboratory abnormalities:
Very common (10% or more): Increased AST (86%), increased ALT (86%), increased ALP (52%), hypocalcemia (52%), hypophosphatemia (28%), hyperbilirubinemia (25%). hypomagnesemia (19%), hypokalemia (18%), hyponatremia (10%), increased thyroid stimulating hormone (TSH)

Psychiatric

Common (1% to 10%): Anxiety (9%)

Respiratory

Very common (10% or more): Dysphonia (20%)

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