What is the success rate of Cabometyx (cabozantinib)?
Cabometyx (cabozantinib) is a tyrosine kinase inhibitor used to treat certain patients with advanced renal cell carcinoma, hepatocellular (liver) cancer, or advanced or metastatic differentiated thyroid cancer.
It is a chemotherapy drug that you take until your cancer starts to get worse - disease progression - or you can no longer tolerate the drug because of side effects or adverse reactions.
How successful Cabometyx is can be measured by how long patients take the treatment for, how long they survive for without their cancer getting worse (progression-free survival), how many months they remain alive for while taking the treatment and how many patients respond to the drug.
How effective is Cabometyx?
| Trial | Duration of treatment | Median progression-free survival (PFS), overall survival (OS) and overall response rate (ORR) |
| METEOR - advanced renal cell carcinoma |
Cabometyx: 7.6 months (range 0.3 - 20.5) vs Everolimus (Afinitor): 4.4 months (range 0.21 - 18.9) |
PFS Cabometyx: 7.4 months (95% CI 5.6, 9.1) vs Everolimus: 3.8 months (95% CI 3.7, 5.4) OS Partial responses only Cabometyx: 17% (95% CI 13%, 22%) vs Everolimus: 3% (95% CI 2%, 6%) |
| CABOSUN - advance renal cell carcinoma |
Cabometyx: 6.5 months (range 0.2 - 28.7) vs Sunitinib (Sutent): 3.1 months (range 0.2 - 25.5) |
PFS Cabometyx: 8.6 months (95% CI 6.8, 14.0) vs Everolimus: 5.3 months (95% CI 3.0, 8.2) ORR |
| CHECKMATE-9ER - advanced renal cell carcinoma, first-line treatment | Cabometyx plus nivolumab (Opdivo): 14 months (range 0.2 - 27) |
PFS Cabometyx: 16.6 months (95% CI 12.5, 24.9) vs Sunitinib: 8.3 months (95% CI 7.0, 9.7) OS Complete and partial responses Cabometyx: 55.7% (95% CI 50.1, 61.2) vs Sunitinib: 27.1% (95% CI 22.4, 32.3) |
| CELESTIAL - advanced hepatocellular carcinoma |
Cabometyx: 3.8 months (range 0.1 - 37.3) vs Placeo: 2.0 months (range 0.0 - 27.2) |
PFS Cabometyx: 5.2 months (95% CI 4.0, 5.5) vs Placebo: 1.9 months (95% CI 1.9, 1.9) OS Partial responses only Cabometyx: 4% (95% CI2.3, 6.0) vs Placebo: 0.4% (95% CI 0.0, 2.3) |
| COSMIC-311 - radioiodine-refractory differentiated thyroid cancer previously treated with VEGFR-targeted therapy |
PFS (updated analysis) Cabometyx: 11 months (95% CI 7.4, 13.8) vs Placebo: 1.9 months (95% CI 1.9, 3.7) ORR (updated analysis) |
Related Questions
References
- Food and Drug Administration (FDA). Cabometyx. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/208692s012lbl.pdf. [Accessed September 27, 2021].
Read next
Related medical questions
- What is the success rate of Keytruda?
- What is the difference between Opdivo and Keytruda?
- Pembrolizumab vs. nivolumab: How do they compare?
- How long does it take for Lenvima to work?
- How does Nexavar work? Is it a chemo drug?
- How long do you take Lenvima?
- Is Nexavar cost covered by Medicare?
- How effective is Nexavar? Does it shrink tumors?
- What type of drug is Lenvima? Is it a chemo drug?
- How are Inlyta and Keytruda used in kidney cancer?
- What is the difference between Mvasi and Avastin?
- How long can you take Afinitor for?
- Does Votrient cure cancer or shrink tumors?
- Does Sutent shrink tumors?
- How long do you take Sutent before it starts to work?
- How long does Votrient stay in your system?
- Is Sutent considered a chemotherapy drug?
- How effective is Lenvima?
- Is Votrient a chemotherapy treatment?
- Is Votrient immunotherapy?
- Who makes Bavencio and where is it made?
- What type of drug is Bavencio?
Drug information
Related support groups
- Cabometyx (7 questions, 10 members)
- Cabozantinib (5 questions, 6 members)
- Renal Cell Carcinoma (29 questions, 102 members)
- Hepatocellular Carcinoma (20 questions, 23 members)
- Thyroid Cancer (13 questions, 44 members)
