Combigan Side Effects

Please note - some side effects for Combigan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Combigan - for the Consumer

Combigan Drops

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Combigan Drops:

Bloodshot eyes; drowsiness; dry eyes; feeling that something is in your eye; headache; increased tear production; minor burning, itching, or stinging of the eye; nausea.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; confusion; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, or swelling; fainting; mental or mood changes; muscle weakness; pain, numbness, weakness, or tingling of an arm or leg; severe or persistent headache or dizziness; severely cold, numb, or blue fingers or toes; shortness of breath; slow or irregular heartbeat; slurred speech; sudden unusual weight gain; swelling of the hands, ankles, or feet; vision changes.

Combigan Side Effects - for the Professional

Combigan

Most common adverse reactions occurring in approximately 5 to 15% of patients included allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging. (6.1)

Side Effects by Body System

Ocular

Ocular side effects have included allergic conjunctivitis, follicular conjunctivitis, conjunctival hyperemia, eye pruritis, ocular burning, and stinging. Also reported were diplopia, choroidal detachment following filtration surgery, cystoid macular edema, decreased corneal sensitivity, pseudophemphigoid ptosis, refractive changes, blepharitis, blepharoconjunctivitis, conjunctival edema, conjunctival hemorrhage, conjunctivitis, blurred vision, corneal erosion, epiphora, eye discharge, eye dryness, eye irritation, eye pain, eyelid edema, eyelid pruritis, lid disorder, tearing, visual field defect, vitreous detachment, vitreous disorder, vitreous floaters, worsened visual acuity, iritis, keratoconjunctivitis sicca, miosis, foreign body sensation, superficial punctate keratitis, and visual disturbance.

Cardiovascular

Cardiovascular side effects have included arrythmia, bradycardia, tachycardia, cardiac arrest, cardiac failure, cerebral ischemia, cerebral vascular accident, claudication, cold hands and feet, edema, heart block, palpitation, pulmonary edema, Raynaud's phenomena, syncope, and worsening of angina pectoris.

Gastrointestinal

Gastrointestinal side effects have included anorexia, diarrhea, gastrointestinal pain, gastrointestinal disorder, dyspepsia, hepatomegaly, ischemic colitis, mesenteric arterial thrombosis, diarrhea, vomiting, and nausea.

Immunologic

Immunologic side effects have included systemic lupus erythematosus.

Nervous system

Nervous system side effects have included increased signs and symptoms of myasthenia gravis, insomnia, nightmares, paresthesias, headache, asthenia, somnolence, dizziness, fatigue, photophobia, taste perversion, confusion, slightly clouded sensorium, and vertigo

Psychiatric

Psychiatric side effects have included hallucinations, anxiety, disorientation, nervousness, memory loss, behavorial changes and psychic disturbances, slightly clouded sensorium, decreased performance on neuropsychometrics, diminished concentration, emotional liability, an acute reversible syndrome characterized by disorientation for time and place, and reversible mental depression progressing to catatonia.

Respiratory

Respiratory side effects have included cough, oral dryness, dyspnea, bronchitis, bronchial obstruction, rales, bronchospasm, nasal dryness, dyspnea, nasal congestion, rhinitis, sinus infection, sinusitis, pharyngitis, colds, and respiratory infections.

Hematologic

Hematologic side effects have included agranulocytosis, nonthrombocytopenic purpura, and thrombocytopenic purpura,

Genitourinary

Genitourinary side effects have included urination difficulties, decreased libido, impotence, Peyronie's disease, and retroperitoneal fibrosis.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, angioedema, urticaria, fever combined with aching and sore throat, laryngospasm with respiratory distress, erythematous rash and both generalized and localized rash.

Endocrine

Endocrine side effects have included masking of symptoms of hypoglycemia in diabetic patients, hypercholesterolemia, hyperglycemia, and hypoglycemia.

General

General side effects have included decreased exercise tolerance, extremity pain, local weakness, weight loss, tinnitus, flu syndrome, and abnormal taste.

Musculoskeletal

Musculoskeletal side effects have included arthralgia.

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